2009 Fiscal Year Final Research Report
Relationship between surrogate markers including DNA methylation and lifestyle factors in gastric carcinogenesis
| Project/Area Number |
17015013
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YUASA Yasuhito Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80111558)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIHARA Kenichi 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10171167)
KAWANO Tatsuyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (00186115)
TAKIZAWA Touichiro 東京医科歯科大学, 大学院・保健衛生学科, 教授 (80323674)
IMAI Kazue (財)放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (80260230)
AKIYAMA Yosimitsu 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (80262187)
FUKAMACHI Hiroshi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70134450)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIHARA Kenichi 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10171167)
KAWANO Tatsuyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00186115)
TAKIZAWA Touichiro 東京医科歯科大学, 大学院・保健衛生学科, 教授 (80323674)
IMAI Kazue (財)放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (80260230)
FUKAMACHI Hiroshi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70134450)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 胃がん / エピジェネティクス / DNAメチル化 / 実験動物モデル |
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| Research Abstract |
Epigenetic silencing of genes by aberrant DNA methylation is recognized as a crucial component of the mechanism underlying tumorigenesis. We examined the methylation statuses of six tumor-related genes in 106 primary gastric carcinomas by methylation-specific PCR and compared them with the past lifestyles of the patients. Significant association was found between a decreased intake of green tea and methylation of CDX2 and BMP-2. More physical activity was correlated with a lower methylation frequency of CACNA2D3. Thus, some epidemiological factors, such as green tea intake, could be important as to determination of the methylation statuses of selected genes and may influence the development of cancer, including that of the stomach.
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[Journal Article] GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer.2009
Author(s)
Hellebrekers DMEI, Lentjes, MHFM, van den Bosch SM, Wouters AD, Daenen K, Melotte V, Smits KM, Partouns-Hendriks IEJM, Akiyama Y, Yuasa Y, Sanduleanu S, Khalid-de Bakker C, Jonkers D, Weijenberg MP, Louwagie J, van Criekinge W, Carvalho B, Meijer GA, Baylin SB, Herman JG, de Bruine AP & van Engeland M
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Journal Title
Clinical Cancer Res. 15
Pages: 3990-3997
Peer Reviewed
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[Journal Article] Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer.2008
Author(s)
Wanajo A, Sasaki A, Nagasaki H, Shimada S, Otsubo T, Owaki S, Shimizu Y, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y
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Journal Title
Gastroenterology 135
Pages: 80-590
Peer Reviewed
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[Journal Article] RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis.2008
Author(s)
Ito K, Lim A.C. -B, Salto-Tellez M, Motoda L, Osato M, Chuang L.S. H, Lee C.W. L, Voon D.C. -C, Koo J.K. W, Wang H, Fukamachi H, Ito Y
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Journal Title
Cancer Cell 14
Pages: 226-237
Peer Reviewed
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[Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.2007
Author(s)
Taniwaki K, Fukamachi H, Komori K, Ohtake Y, Nonaka T, Sakamoto T, Shiomi T, Okada Y, Itoh T, Itohara S, Seiki M, Yana I
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Journal Title
Cancer Res. 67
Pages: 4311-4319
Peer Reviewed
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[Journal Article] Inhibition of DNA binding of Sox2 by the SUMO conjugation.2006
Author(s)
Tsuruzoe S, Ishihara K, Uchimura Y, Watanabe S, Sekita Y, Aoto T, Saitoh H, Yuasa Y, Niwa H, Kawasuji M, Baba H, Nakao M
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Journal Title
Biochem. Biophys. Res. Commun. 351
Pages: 920-926
Peer Reviewed
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[Journal Article] The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor s-induced apoptosis.2006
Author(s)
Yano T, Ito K, Fukamachi H, Chi X-Z, Wee H-J, Inoue K, Ida H, Bouillet P, Strasser A, Bae S-C, Ito Y
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Journal Title
Mol Cell Biol 26
Pages: 4474-4488
Peer Reviewed
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[Journal Article] Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients.2005
Author(s)
Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, Takizawa T, Koike M, Tani M, Iwai T, Sugihara K, Imai K, Nakachi K
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Journal Title
Carcinogenesis 26
Pages: 193-20
Peer Reviewed
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