2009 Fiscal Year Final Research Report
Biomarkers related to carcinogenesis and surrogate markers for cancer prevention
Project/Area Number |
17015020
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Nagoya University |
Principal Investigator |
HAMAJIMA Nobuyuki Nagoya University, 大学院・医学系研究科, 教授 (30172969)
|
Co-Investigator(Kenkyū-buntansha) |
EGUCHI Hidetaka 埼玉医科大学, 医学部, 准教授 (00260232)
|
Project Period (FY) |
2005 – 2009
|
Keywords | 生活習慣 / 遺伝子多型 / ピロリ菌感染 / 慢性萎縮性胃炎 / 葉酸 / 尿酸 / 腫瘍マーカーCA19-9 |
Research Abstract |
Biomarkers associated with carcinogenesis could be used as surrogate markers for the evaluation of cancer prevention. This study examined the associations of markers related to carcinogenesis and cancer diagnosis with lifestyle and genotypes. The following associations were observed; 1) a PTPN11 polymorphism with chronic atrophic gastritis, 2) MTHFR C609T with serum folate, 3) genotypes of ecNOS, SLC22A12 and ABCG2 with serum urate, 4) ACE I/D with ACE activity, 5) genotypes of Le and Se with serum CA19-9, and 6) IL-8 T-251 with serum IL-8.
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[Journal Article] Association between circulating IL-8 levels, IL-8 T-251A genotypes and Helicobacter pylori infection2010
Author(s)
Naito M, Eguchi H, Goto Y, Kondo T, Nishio K, Ishida Y, Kawai S, Okada R, Hishida A, Wakai K, Hamajima N.
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Journal Title
Epidemiol Infect 138
Pages: 512-518
Peer Reviewed
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[Journal Article] Common defects of ABCG2, a high-capacity urate exporter, cause gout: a functional-based genetic analysis in a Japanese population2009
Author(s)
Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki K, Hamajima N, Shinomiya N.
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Journal Title
Science Translational Med 1(5-8)
Pages: 41-48
Peer Reviewed
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[Journal Article] Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese2009
Author(s)
Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.
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Journal Title
Helicobacter 14
Pages: 47-53
Peer Reviewed
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[Journal Article] Significant association between Helicobacter pylori infection and C-ractive protein2008
Author(s)
Ishida Y, Suzuki K, Taki K, Niwa T, Kurotsuchi S,, o H, Iwase A, Nishio K, Wakai K, Ito Y, Hamajima N.
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Journal Title
Int J Med Sci 5
Pages: 224-229
Peer Reviewed
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