Biomarkers related to carcinogenesis and surrogate markers for cancer prevention

2009 Fiscal Year Final Research Report

• Project/Area Number: 17015020
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: HAMAJIMA Nobuyuki Nagoya University, 大学院・医学系研究科, 教授 (30172969)
• Co-Investigator(Kenkyū-buntansha): EGUCHI Hidetaka 埼玉医科大学, 医学部, 准教授 (00260232)
• Project Period (FY): 2005 – 2009
• Keywords: 生活習慣 / 遺伝子多型 / ピロリ菌感染 / 慢性萎縮性胃炎 / 葉酸 / 尿酸 / 腫瘍マーカーCA19-9

Research Abstract

Biomarkers associated with carcinogenesis could be used as surrogate markers for the evaluation of cancer prevention. This study examined the associations of markers related to carcinogenesis and cancer diagnosis with lifestyle and genotypes. The following associations were observed; 1) a PTPN11 polymorphism with chronic atrophic gastritis, 2) MTHFR C609T with serum folate, 3) genotypes of ecNOS, SLC22A12 and ABCG2 with serum urate, 4) ACE I/D with ACE activity, 5) genotypes of Le and Se with serum CA19-9, and 6) IL-8 T-251 with serum IL-8.

Research Products

• [Journal Article] Association between circulating IL-8 levels, IL-8 T-251A genotypes and Helicobacter pylori infection (2010)
  • Author(s): Naito M, Eguchi H, Goto Y, Kondo T, Nishio K, Ishida Y, Kawai S, Okada R, Hishida A, Wakai K, Hamajima N.
  • Journal Title: Epidemiol Infect 138 Pages: 512-518
  • Peer Reviewed
• [Journal Article] Common defects of ABCG2, a high-capacity urate exporter, cause gout: a functional-based genetic analysis in a Japanese population (2009)
  • Author(s): Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki K, Hamajima N, Shinomiya N.
  • Journal Title: Science Translational Med 1(5-8) Pages: 41-48
  • Peer Reviewed
• [Journal Article] Significant association between methylenetetrahydrofolate reductase (MTHFR) 677T allele and hyperuricemia among adult Japanese subjects (2009)
  • Author(s): Itou S, Goto Y, Suzuki K, Kawai S, Naito M, Ito Y, Hamajima N.
  • Journal Title: Nutr Res 29 Pages: 710-715
  • Peer Reviewed
• [Journal Article] RUNX3 polymorphisms, Helicobacter pylori seropositivity, and risk of gastric atrophy and cancer in Japanese (2009)
  • Author(s): Hishida A, Matsuo K, Goto Y, Mitsuda Y, Naito M, Wakai K, Tajima K, Hamajima N.
  • Journal Title: J Gastroenterol 44 Pages: 1165-1171
  • Peer Reviewed
• [Journal Article] Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese (2009)
  • Author(s): Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.
  • Journal Title: Helicobacter 14 Pages: 47-53
  • Peer Reviewed
• [Journal Article] Smoking and serum CA19-9 levels according to Lewis and Secretor genotypes (2008)
  • Author(s): Kawai S, Suzuki K, Nishio K, Ishida Y, Okada R, Goto Y, Naito M, Wakai K, Ito Y, Hamajima N.
  • Journal Title: Int J Cancer 123 Pages: 2880-2884
  • Peer Reviewed
• [Journal Article] Significant association between Helicobacter pylori infection and C-ractive protein (2008)
  • Author(s): Ishida Y, Suzuki K, Taki K, Niwa T, Kurotsuchi S,, o H, Iwase A, Nishio K, Wakai K, Ito Y, Hamajima N.
  • Journal Title: Int J Med Sci 5 Pages: 224-229
  • Peer Reviewed
• [Journal Article] Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake (2008)
  • Author(s): Nishio K, Goto Y, Kondo T, Ito S, Ishida Y, Kawai S, Naito M, Wakai K, Hamajima N.
  • Journal Title: J Epidemiol 18 Pages: 125-131
  • Peer Reviewed
• [Journal Article] No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese (2007)
  • Author(s): Itou S, Goto Y, Kondo T, Nishio K, Kawai S, Ishida Y, Naito M, Hamajima N.
  • Journal Title: Int J Med Sci 4 Pages: 98-104
  • Peer Reviewed
• [Journal Article] Association between serum pepsinogens and polymorphism of PTPN11 encoding SHP-2 among Helicobacter pylori seropositive Japanese (2006)
  • Author(s): Goto Y,, o T, Yamamoto K, Tamakoshi A, El-Omar E, Goto H, Hamajima N.
  • Journal Title: Int J Cancer 118 Pages: 203-208
  • Peer Reviewed
• [Presentation] Genetic traits for H. pylori persistent infection, atrophic gastritis, and gastric carcinogenesis (2010)
  • Author(s): Hamajima N.
  • Organizer: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. Cancer Genomics, Epigenetics, and the Development of Novel Therapeutics
  • Place of Presentation: Hawaii
  • Year and Date: 2010-02-07
• [Presentation] ゲノム多型性はバイオマーカーとなりうるか? (2009)
  • Author(s): 浜島信之
  • Organizer: 第7回日本臨床腫瘍学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-20
• [Presentation] Goto Y. PTPN11 genotype: a genetic trait of H. pylori related gastric cancer at the step of atrophy development (2007)
  • Author(s): Hamajima N, Goto Y.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-20071005
• [Presentation] Genetic traits for H. pylori persistent infection, atrophic gastritis, and gastric carcinogenesis (2007)
  • Author(s): Hamajima N.
  • Organizer: 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. In the Forefront of Basic and Translational Cancer Research
  • Place of Presentation: Hawaii
  • Year and Date: 2007-01-22
• [Presentation] Genetic traits for gastric strophy among Helicobacter pylori infected individuals (2006)
  • Author(s): Hamajima N.
  • Organizer: The 5rd Sino-Japan Joint Conference for Cancer Research
  • Place of Presentation: Shanghai
  • Year and Date: 20061006-20061007