Epidemiological study of HPV-related cancers in Asia-Pacific region

2009 Fiscal Year Final Research Report

• Project/Area Number: 17015037
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kagoshima University
• Principal Investigator: AKIBA Suminori Kagoshima University, 大学院・医歯学総合研究科, 教授 (50145554)
• Research Collaborator: ANDRES Castillo Kagoshima University, Dental Sciences ; KHAN Noureen Kagoshima University, Dental Sciences ; SHUYAMA Karem Kagoshima University, Dental Sciences ; AGUAYO Francisco Kagoshima University, Dental Sciences ; ANWAR Muhamad Kagoshima University, Dental Sciences ; TOMMASINO Massimo International Agency for Research on Cancer, France
• Project Period (FY): 2005 – 2009
• Keywords: 疫学 / 癌 / ウイルス / 環境要因 / 遺伝的背景

Research Abstract

Detection of human papillomavirus (HPV), a widely-accepted risk factor of cervical cancer, has been reported in other types of carcinomas including cancers of the esophagus and the lung. To clarify the effects of interactions among environmental factors including radiation exposure and lifestyles, viral factors, and genetic factors on carcinogenesis, this study examine epidemiological, clinic-pathological, viral, and molecular biological features of virus (mainly HPV)-related cancers in comparison with those of non-virus-related cancers.
HPV genome was detected in 10-30% of carcinomas of the esophagus, the lung, and the breast, and its detection rate varied by regions and histological type of tumors. The most frequent genotype was high-risk type of HPV-16 in all sites of tumors. Although real-time PCR analysis indicated the presence of integrated-form of viral DNA in most of HPV-16-positive specimens, the estimated viral load was significantly lower (around 0.1 copy per cell) than that of cervical cancers. These results suggested that the role of HPV in carcinogenesis differ between these organs and cervix.
On the other hand, we observed the high frequency of HPV-positive cases among gefitinib-responsive lung adenocarcinomas, and the high frequency of high-risk types of HPV and high viral load in cancers in a high background radiation area. Further investigations are warranted to examine HPV interactions with genetic and other environmental factors.

Research Products

• [Journal Article] Frequent expression of thymidine phosphorylase in Epstein-Barr virus-associated gastric carcinoma of diffuse-type. (2010)
  • Author(s): Koriyama C, Akiba S, Shimaoka S, Itoh T, Akiyama S, Eizuru Y.
  • Journal Title: Anticancer Research (in press)
  • Peer Reviewed
• [Journal Article] Human papillomavirus is frequently detected in gefitinibresponsive lung adenocarcinomas. (2010)
  • Author(s): Baba M, Castillo A, Koriyama C, Yanagi M, Matsumoto H, Natsugoe S, Shuyama KY, Khan N, Higashi M, Itoh T, Eizuru Y, Aikou T, Akiba S.
  • Journal Title: Oncology Reports 23(4) Pages: 1085-1092
  • Peer Reviewed
• [Journal Article] Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis. (2009)
  • Author(s): Cazzaniga M, Gheit T, Casadio C, Khan N, Macis D, Valenti F, Miller MJ, Sylla BS, Akiba S, Bonanni B, Decensi A, Veronesi U, Tommasino M.
  • Journal Title: Breast Cancer Res Treat. 114(3) Pages: 599-605
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features. (2008)
  • Author(s): Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y.
  • Journal Title: Cancer Science. 99(2) Pages: 195-201
  • Peer Reviewed
• [Journal Article] Human papillomavirus detected in female breast carcinomas in Japan. (2008)
  • Author(s): Khan NA, Castillo A, Koriyama C, Kijima Y, Umekita Y, Ohi Y, Higashi M, Sagara Y, Yoshinaka H, Tsuji T, Natsugoe S, Douchi T, Eizuru Y, Akiba S.
  • Journal Title: British Journal of Cancer 99(3) Pages: 408-414
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus associated gastric carcinoma: a report from Iran in the last four decades. (2007)
  • Author(s): Abdirad A, Ghaderi-Sohi S, Shuyama K, Koriyama C, Nadimi-Barforoosh H, Emami S, Mosavi-Jarrahi A, Nahvijou A, Akiba S.
  • Journal Title: Diagn Pathol 2(1) Pages: 25
  • Peer Reviewed
• [Journal Article] E-cadherin and beta-catenin expression in Epstein-Barr virusassociated gastric carcinoma and their prognostic significance. (2007)
  • Author(s): Koriyama C, Akiba S, Itoh T, Sueyoshi K, Minakami Y, Corvalan A, Yonezawa S, Eizuru Y.
  • Journal Title: World J Gastroenterol. 13(29) Pages: 3925-31
  • Peer Reviewed
• [Journal Article] Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile. (2007)
  • Author(s): Aguayo F, Castillo A, Koriyama C, Higashi M, Itoh T, Capetillo M, Shuyama K, Corvalan A, Eizuru Y, Akiba S.
  • Journal Title: Br J Cancer. 97(1) Pages: 85-91
  • Peer Reviewed
• [Journal Article] Human papillomavirus in high- and low-risk areas of oesophageal squamous cell carcinoma in China. (2007)
  • Author(s): Shuyama K, Castillo A, Aguayo F, Sun Q, Khan N, Koriyama C, Akiba S.
  • Journal Title: Br J Cancer. 96(10) Pages: 1554-1559
  • Peer Reviewed
• [Journal Article] Down regulation of gastric and intestinal phenotypic expression in Epstein-Barr virus-associated stomach cancers. (2007)
  • Author(s): Hirano N, Tsukamoto T, Mizoshita T, Koriyama C, Akiba S, Campos F, Carrasquilla G, Carrascal E, Cao X, Toyoda T, Ban H, Miki K, Tatematsu M.
  • Journal Title: Histol Histopathol. 22(6) Pages: 641-649
  • Peer Reviewed
• [Journal Article] Nasal natural killer/T-cell lymphoma and its association with type "I"/XhoI loss strain Epstein-Barr virus in Chile. (2007)
  • Author(s): Cabrera ME, Eizuru Y, Itoh T, Koriyama C, Tashiro Y, Ding S, Rey S, Akiba S, Coravalan A.
  • Journal Title: J Clin Pathol. 60(6) Pages: 656-660
  • Peer Reviewed
• [Journal Article] Environmental factors related to gastric cancer associated with Epstein-Barr virus in Colombia. (2006)
  • Author(s): Campos FI, Koriyama C, Akiba S, Carrasquilla G, Serra M, Carrascal E, Itoh T, Minakami Y, Eizuru Y.
  • Journal Title: Asian Pac J Cancer Prev. 7(4) Pages: 633-637
  • Peer Reviewed
• [Journal Article] Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile. (2006)
  • Author(s): Castillo A, Aguayo F, Koriyama C, Torres M, Carrascal E, Corvalan A, Roblero JP, Naquira C, Palma M, Backhouse C, Argandona J, Itoh T, Shuyama K, Eizuru Y, Akiba S.
  • Journal Title: World J Gastroenterol. 12(38) Pages: 6188-6192
  • Peer Reviewed
• [Journal Article] Human papillomavirus in lung carcinomas among three Latin American countries. (2006)
  • Author(s): Castillo A, Aguayo F, Koriyama C, Shuyama K, Akiba S, Herrera-Goepfert R, Carrascal E, Klinge G, Sanchez J, Eizuru Y.
  • Journal Title: Oncology Reports. 15(4) Pages: 883-888
  • Peer Reviewed
• [Journal Article] Association of a distinctive strain of Epstein-Barr virus with gastric cancer. (2006)
  • Author(s): Corvalan A, Ding S, Koriyama C, Carrascal E, Carrasquilla G, Backhouse C, Urzua L, Argandona J, Palma M, Eizuru Y, Akiba S.
  • Journal Title: Int. J. Cancer. 118(7) Pages: 1736-1742
  • Peer Reviewed
• [Presentation] Human papillomavirus is frequently detected in gefitinib-responsive lung adenocarcinomas (2009)
  • Author(s): Koriyama C, Baba M, Castillo A, Yanagi M, Matsumoto H, Eizuru Y, Akiba S, et al.
  • Organizer: 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20091001-20091003
• [Presentation] Human papillomavirus-16 (HPV-16) detected in squamous cell lung cancer. (2008)
  • Author(s): Aguayo F, Koriyama C, Akiba S, Eizuru Y, et al.
  • Organizer: AACR International Conference on Frontiers in Cancer Prevention Research.
  • Place of Presentation: Washington DC, US
  • Year and Date: 20081116-20081119
• [Presentation] Clinico-pathological features and prognostic factors of Epstein-Barr virus-associated gastric carcinoma (2008)
  • Author(s): Koriyama C, Akiba S, Higashi M, Campos F, Sueyoshi K, Yonezawa S, Eizuru Y.
  • Organizer: The 8th International Conference of Anticancer Research
  • Place of Presentation: Kos, Greece
  • Year and Date: 20081017-20081022
• [Presentation] Identification of humanpapillomavirus DNA sequences in female breast carcinomas in Japan. (2008)
  • Author(s): Khan N, Koriyama C, Akiba S, et al.
  • Organizer: NCRI Cancer Conference
  • Place of Presentation: Birmingham, UK
  • Year and Date: 20081005-20081008
• [Presentation] Human papillomavirus DNA sequences in breast carcinomas in Japan and Pakistan. (2008)
  • Author(s): Khan N, Koriyama C, Castillo A, Shuyama K, Eizuru Y, Akiba S.
  • Organizer: Second JCA-AACR Special Joint Conference
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 20080714-20080716
• [Presentation] 非生殖系臓器のがんにおけるヒトパピローマウイルスの役割 (2008)
  • Author(s): 郡山千早、秋葉澄伯、Noureen Khan
  • Organizer: がん予防大会
  • Place of Presentation: 福岡
  • Year and Date: 20080522-20080523
• [Presentation] Human papillomavirus in high and low risk areas of esophageal squamous cell carcinoma in China (2007)
  • Author(s): Akiba S, Castillo A, Khan N, Koriyama C.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20071003-20071005
• [Presentation] Human papillomavirus type 16 variants in esophageal and lung cancer: an international study. (2007)
  • Author(s): Castillo A, Koriyama C, Yanagi M, Eizuru T, Akiba S, et al.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20071003-20071005
• [Presentation] Gastric and intestinal mucin expressions in Epstein-Barr virus- associated gastric carcinoma (2007)
  • Author(s): Koriyama C, Eizuru Y, Akiba S, et al.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20071003-20071005
• [Presentation] Distribution of Epstein-Barr virus (EBV) strains in EBV-associated gastric cancers. (2006)
  • Author(s): Koriyama C, Akiba S, Eizuru Y, et al.
  • Organizer: 4th APOCP Regional Conference
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-01-20