Development of personalized medicine and therapeutic strategies for pediatric solid tumors

2009 Fiscal Year Final Research Report

• Project/Area Number: 17015046
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Chiba Cancer Center (Research Institute)
• Principal Investigator: NAKAGAWARA Akira Chiba Cancer Center (Research Institute), センター長 (50117181)
• Project Period (FY): 2005 – 2009
• Keywords: 小児がん / 個別化診断 / 個別化治療 / 神経芽腫 / DNAチップ

Research Abstract

We have aimed to establish new diagnostic systems to predict prognosis of neuroblastoma and hepatoblastoma, which are typical childhood solid tumors, by using comprehensive methodology including genomics and proteomics. The childhood cancers-proper cDNA libraries we generated previously and the BAC clones-based array-CGH methods were introduced. We could successfully generate a practically usable mini-chip carrying top ranked 200 genes to predict the prognosis of neuroblastoma. In addition, our array-CGH analysis made it possible to generate a genome-based risk classification of neuroblastoma which is now applicable to the clinical study. The novel serum prognostic factors have also been identified. Furthermore, we found new neuroblastoma genes including KIF1Bbeta, RUNX3 and ALK which is often amplified and mutated in primary neuroblastomas.

Research Products

• [Journal Article] MCL-IV, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair. (2010)
  • Author(s): Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K.
  • Journal Title: Biochem. Biophys. Res. Commun. 391 Pages: 492-497
  • Peer Reviewed
• [Journal Article] LMO3 interacts with p53 and inhibits its transcriptional activity. (2010)
  • Author(s): Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 392 Pages: 252-257
  • Peer Reviewed
• [Journal Article] Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature. (2010)
  • Author(s): De Katleen P, Vermeulen J, Brors B, Delattre O, Eggert A, Fischer M, Janoueix-Lerosey I, Lavarino C, Maris JM, Mora J, Nakagawara A, Oberthuer A, Ohira M, Schleiermacher G, Schramm A, Schulte JH, Wang Q, Westermann F, Speleman F, Vandesompele J.
  • Journal Title: Clin. Cancer Res. 16 Pages: 1532-1541
  • Peer Reviewed
• [Journal Article] Bmil is a MYCN target gene and regulates tumorigenesis via repression of KIF1B 13 and TSLC1 in neuroblastoma. (2010)
  • Author(s): Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kami jo T.
  • Journal Title: Oncogene 29 Pages: 2681-2690
  • Peer Reviewed
• [Journal Article] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-activator for p53. (2010)
  • Author(s): Yamada C, Ozaki T, Ando K, Suenaga Y, Inoue Kt, Ito Y, Okoshi R, Kageyama H, Kimura H, Miyazaki M, Nakagawara A.
  • Journal Title: J. Biol. Chem. 285 Pages: 16693-166703
  • Peer Reviewed
• [Journal Article] Clinicopathological relevance of UbcH10 in breast cancer. (2009)
  • Author(s): Fujita T, Ikeda H, Kawasaki K, Taira N, Ogasawara Y, Nakagawara A, Doihara H.
  • Journal Title: Cancer Sri. 100 Pages: 238-248
  • Peer Reviewed
• [Journal Article] Distinct role of ShcC docking rotein in the differentiation of neuroblastoma. (2009)
  • Author(s): Miyake I, Ohira M, Nakagawara A, Sakai R.
  • Journal Title: Oncogene 28 Pages: 662-673
  • Peer Reviewed
• [Journal Article] International consensus for neuroblastoma molecular diagnostics: Report from the international neuroblastoma risk group (INRG) biology committee. (2009)
  • Author(s): Ambros PF, Ambros TM, Brodeur GM, Haber M, Khan J, Nakagawara A, Schleiermacher G, Speleman F, Spitz R, London WB, Cohn SL, Pearson ADJ, Maris JM.
  • Journal Title: Br. J. Cancer 100 Pages: 1471-1482
  • Peer Reviewed
• [Journal Article] Netrin-1 acts as a survival factor for aggressive neuroblastoma. (2009)
  • Author(s): Delloye-Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc-Rasy S, Raquin MA, Stupack D, Nakagawara A, Rousseau R, Combaret V, Puisieux A, Valteau-Couanet D, Benard J, Bernet A, Mehlen P.
  • Journal Title: J. Exp. Med. 206 Pages: 833-847
  • Peer Reviewed
• [Journal Article] Plkl regulates liver tumor cell death by phosphorylation of TAp63. (2009)
  • Author(s): Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T.
  • Journal Title: Oncogene 28 Pages: 3631-3641
  • Peer Reviewed
• [Journal Article] Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73. (2009)
  • Author(s): Ozaki T, Okoshi R, Sang M, Kubo N, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 386 Pages: 207-211
  • Peer Reviewed
• [Journal Article] Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity. (2009)
  • Author(s): Ozaki T, Okoshi R, Ono S, Kubo N, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 387 Pages: 143-148
  • Peer Reviewed
• [Journal Article] P1k3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. (2009)
  • Author(s): Sang M, Ando K, Okoshi R, Koida N, Li Y, Zhu Y, Shimozato O, Geng C, Shan B, Nakagawara A, Ozaki T.
  • Journal Title: Genes Cells 14 Pages: 775-788
  • Peer Reviewed
• [Journal Article] A simple PCR method for rapid genotype analysis of the TH柚YCN transgenic mouse. (2009)
  • Author(s): Haraguchi S, Nakagawara A.
  • Journal Title: PLoSONE 4 Pages: e6902
  • Peer Reviewed
• [Journal Article] Positive auto-egulation of MYCN in human neuroblastoma. (2009)
  • Author(s): Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 390 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Dysregulation of PDGFb-receptor expression by DNp73 in neuroblastoma. (2009)
  • Author(s): Wetterskog D, Ozaki T, Nakagawara A, Funa K.
  • Journal Title: Mol. Cancer Res. 7 Pages: 2031-2039
  • Peer Reviewed
• [Journal Article] ROS-generating mitochondrial DNA mutation upregulates hypozia-inducible factor-la gene transcription via PI3K-Akt/PKC/HDAC pathway. (2009)
  • Author(s): Koshikawa N, Hayashi J-I, Nakagawara A*, Takenaga K*.
  • Journal Title: J. Biol. Chem. 284 Pages: 33185-33194
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of tumor suppressor p53 by CREB/AMPK complex in response to glucose deprivation. (2009)
  • Author(s): Okoshi R, Ando K, Suenaga Y, Kizaki H, Nakagawara A, Ozaki T.
  • Journal Title: Genes to Cells. 14 Pages: 1429-1440
  • Peer Reviewed
• [Journal Article] TBP-like protein (TLP/TRF2/TLF) is engaged in etoposide-induced apoptosis through transcriptional activation of human TAp63 gene. (2009)
  • Author(s): Suenaga Y, Ozaki T, Tanaka Y, Bu Y, Kamijo T, Suzuki M, Kimura H, Tokuhisa T, Nakagawara A*, Tamura T*.
  • Journal Title: J. Biol. Chem. 284 Pages: 35433-35440
  • Peer Reviewed
• [Journal Article] TAp63-dependent induction of growth differentiation factor 15 (GDF15) plays a critical role in the regulation of keratinocyte differentiation. (2008)
  • Author(s): Ichikawa T, Suenaga Y, Koda T, Ozaki T, Nakagawara A.
  • Journal Title: Oncogene 27 Pages: 409-420
  • Peer Reviewed
• [Journal Article] Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature. (2008)
  • Author(s): Tomioka N, Oba S, Ohira M, Misra A, Fridly, J, Ishii S, Nakamura Y, Isogai E, Hirata T, Yoshida Y, Todo S, Kaneko Y, Albertson DG, Pinkel D, Feuerstein BG, Nakagawara A.
  • Journal Title: Oncogene 27 Pages: 441-449
  • Peer Reviewed
• [Journal Article] ATM-dependent nuclear accumulation of IKK-a plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin. (2008)
  • Author(s): Yoshida K, Ozaki T, Furuya K, Nakanishi M, Kikuchi H, Yamamoto H, Ono S, Koda T, Omura K, Nakagawara A.
  • Journal Title: Oncogene 27 Pages: 1183-1188
  • Peer Reviewed
• [Journal Article] ERAP140/Nb1a10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid. (2008)
  • Author(s): Arai H, Ozaki T, Niizuma H, Nakamura Y, Ohira M, Takano K, Matsumoto M, Nakagawara A.
  • Journal Title: Oncol. Rep. 19 Pages: 1381-1388
  • Peer Reviewed
• [Journal Article] Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells. (2008)
  • Author(s): Kurata K, Yanagisawa R, Ohira M, Kitagawa M, Nakagawara A, Kamijo T.
  • Journal Title: Oncogene 27 Pages: 741-754
  • Peer Reviewed
• [Journal Article] Spl-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway. (2008)
  • Author(s): Bu Y, Suenaga Y, Ono S, Koda T, Song F, Nakagawara A, Ozaki T.
  • Journal Title: Genes to Cells 13 Pages: 53-66
  • Peer Reviewed
• [Journal Article] Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. (2008)
  • Author(s): Okoshi R, Ozaki T, Yamamoto H, Ando K, Koida N, Ono S, Koda T, Kamijo T, Nakagawara A, Kizaki H.
  • Journal Title: J. Biol. Chem. 283 Pages: 3979-3987
  • Peer Reviewed
• [Journal Article] A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-ediated apoptotic cell death in its catalytic activity-independent manner. (2008)
  • Author(s): Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A.
  • Journal Title: Oncogene 27 Pages: 3700-3709
  • Peer Reviewed
• [Journal Article] DNp63/BMP-7-dependent expression of matrilin-2 is involved in keratinocyte migration in response to wounding. (2008)
  • Author(s): Ichikawa T, Suenaga Y, Koda T, Ozaki T, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 369 Pages: 994-1000
  • Peer Reviewed
• [Journal Article] The methylation status of RASSF1A promoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients. (2008)
  • Author(s): Honda S, Haruta M, Sugawara W, Sasaki F, Ohira M, Matsunaga T, Yamaoka H, Horie H, Ohnuma N, Nakagawara A, Hiyama E, Todo S, Kaneko Y.
  • Journal Title: Int. J. Cancer 123 Pages: 1117-1125
  • Peer Reviewed
• [Journal Article] A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (2008)
  • Author(s): Wang H, Ozaki T, Shamim Hossain M, Nakumura Y, Kamijo T, Xue X, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 370 Pages: 594-598
  • Peer Reviewed
• [Journal Article] Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. (2008)
  • Author(s): Abe M, Watanabe N, McDonell N, Takato T, Ohira M, Nakagawara A, Ushijima T.
  • Journal Title: Oncology 74 Pages: 50-60
  • Peer Reviewed
• [Journal Article] Inhibitory role of Plkl in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. (2008)
  • Author(s): Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A.
  • Journal Title: J. Biol. Chem. 283 Pages: 8555-8563
  • Peer Reviewed
• [Journal Article] NFBD1/MDC1 stabilizes oncogenic MDM2 to contribute to cell fate determination in response to DNA damage. Biochem. (2008)
  • Author(s): Inoue K, Nakanjishi M, Kikuchi H, Yamamoto H, Todo S, Nakagawara A, Ozaki T.
  • Journal Title: Biophys. Res. Commun. 371 Pages: 829-833
  • Peer Reviewed
• [Journal Article] Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system. (2008)
  • Author(s): Nakagawa H, Ohira M, Hayashi S, Abe S, Saito S, Nagahori N, Monde K, Shinohara Y, Fujitani N, Kondo H, Akiyama S, Nakagawara A, Nishimura S.
  • Journal Title: Cancer Lett. 270 Pages: 295-301
  • Peer Reviewed
• [Journal Article] N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. (2008)
  • Author(s): Hossain MS, Ozaki T, Wang H, Nakagawa A, Takenobu H, Ohira M, Kamijo T, Nakagawara A.
  • Journal Title: Oncogene 27 Pages: 6075-6082
  • Peer Reviewed
• [Journal Article] Expression of TSLC1, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylation. (2008)
  • Author(s): Ando K, Ohira M, Ozaki T, Nakagawa A, Akazawa K, Suenaga Y, Nakamura Y, Koda T, KamijoT, Murakami Y, Nakagawara A.
  • Journal Title: Int. J. Cancer 123 Pages: 2087-2094
  • Peer Reviewed
• [Journal Article] KIF1Bb functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36. 2 by inducing apoptotic cell death. (2008)
  • Author(s): Munirajan AK, Ando K, Mukai A, Takahashi M, Suenaga Y, Ohira M, Koda T, Hirota T, Ozaki T, Nakagawara A.
  • Journal Title: J. Biol. Chem. 283 Pages: 24426-24434
  • Peer Reviewed
• [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma. (2008)
  • Author(s): Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S.
  • Journal Title: Nature 455 Pages: 971-974
  • Peer Reviewed
• [Journal Article] Plasma midkine level is a prognostic factor for human neuroblastoma. (2008)
  • Author(s): Ikematsu S, Nakagawara A, Nakamura Y, Ohira M, Shinjo M, Kishida S, Kadomatsu K.
  • Journal Title: Cancer 99 Pages: 2070-2074
  • Peer Reviewed
• [Journal Article] Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma. (2008)
  • Author(s): Honda S, Arai Y, Haruta M, Sasaki F, Ohira M, Yamaoka H, Horie H, Nakagawara A, Hiyama E, Todo S, Kaneko Y.
  • Journal Title: Br. J. Cancer 99 Pages: 1891-1899
  • Peer Reviewed
• [Journal Article] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25. 1, is associated with poor prognosis in neuroblastoma. (2008)
  • Author(s): Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A.
  • Journal Title: Int. J. Oncol. 34 Pages: 931-938
  • Peer Reviewed
• [Journal Article] Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. (2007)
  • Author(s): Abe M, Westermann F, Nakagawara A, Takato T, Schwab M, Ushijima T.
  • Journal Title: Cancer Lett. 247 Pages: 253-258
  • Peer Reviewed
• [Journal Article] Reciprocal expression of CCAAT/enhancer binding proteins a and b in hepatoblastomas and its prognostic significance. Once]. (2007)
  • Author(s): Tomizawa M, Horie H, Yamamoto H, Matsunaga T, Sasaki F, Hashizume K, Hiyama E, Kaneko M, Suita S, Ando H, Hayashi Y, Ohnuma N, Nakagawara A.
  • Journal Title: Reciprocal expression of CCAAT/enhancer binding proteins a and b in hepatoblastomas and its prognostic significance. Oncel. Rep. 17 Pages: 341-344
  • Peer Reviewed
• [Journal Article] Relationship of DDX1 and NAG gene amplification/overexpression to the prognosis of patients with MYCN-amplified neuroblastoma. (2007)
  • Author(s): Kaneko S, Ohira M, Nakamura Y, Isogai E, Nakagawara A, Kaneko M.
  • Journal Title: J. Cancer Res. Clin. Oncel. 133 Pages: 185-192
  • Peer Reviewed
• [Journal Article] Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. (2007)
  • Author(s): Antonelli A, Lenzi L, Nakagawara A, Ozaki T, Chiaretti A, Aloe L.
  • Journal Title: Cancer Investigation 25 Pages: 94-101
  • Peer Reviewed
• [Journal Article] Oxidative stress induces p53-dependent apoptosis in hepatoblastoma cell through its nuclear translocation. (2007)
  • Author(s): Yamamoto H, Ozaki T, Nakanishi M, Kikuchi H, Yoshida K, Horie H, Kuwano H, Nakagawara A.
  • Journal Title: Genes to Cells 12 Pages: 461-471
  • Peer Reviewed
• [Journal Article] Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblastoma cell line. (2007)
  • Author(s): Nakamura Y, Ozaki T, Niizuma H, Ohira M, Kamijo T, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 354 Pages: 892-898
  • Peer Reviewed
• [Journal Article] Purification of human primary neuroblastomas by magnetic beads and their in vitro culture. (2007)
  • Author(s): Nakanishi H, Ozaki T, Nakamura Y, Hashizume K, Iwanaka T, Nakagawara A.
  • Journal Title: Oncel. Rep. 17 Pages: 1315-1320
  • Peer Reviewed
• [Journal Article] Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo. (2007)
  • Author(s): Nimura Y, Kawata T, Uzawa K, Okamura J, Liu C, Saito M, Shimada H, Seki N, Nakagawara A, Ito H, Ochiai T, Tanzawa H.
  • Journal Title: Int. J. Oncol. 30 Pages: 1477-1484
  • Peer Reviewed
• [Journal Article] DFF45/ICAD restores cisplatin-induced nuclear fragmentation but not DNA cleavage in DFF45-deficient neuroblastoma cells. (2007)
  • Author(s): Takahashi M, Ozaki T, Takahashi A, Miyauchi M, Ono S, Takada N, Koda T, Todo S, Kamijo T, Nakagawara A.
  • Journal Title: Oncogene 26 Pages: 5669-5673
  • Peer Reviewed
• [Journal Article] Stabilization of p73 by nuclear IkB kinase-αmediates cisplatin-induced apoptosis. (2007)
  • Author(s): Furuya K, Ozaki T, Hanamoto T, Hosoda M, Hayashi S, Barker PA, Takano K, Matsumoto M, Nakagawara A.
  • Journal Title: J. Biol. Chem. 282 Pages: 18365-18378
  • Peer Reviewed
• [Journal Article] NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage. (2007)
  • Author(s): Nakanishi M, Ozaki T, Yamamoto H, Hanamoto T, Kikuchi H, Furuya K, Asaka M, Delia D, Nakagawara A.
  • Journal Title: J. Biol. Chem. 282 Pages: 22993-23004
  • Peer Reviewed
• [Journal Article] A novel technique for measuring variations in DNA copy-number: competitive genomic polymerase chain reaction. (2007)
  • Author(s): Iwao-Koizumi K, Maekawa K, Nakamura Y, Saito S, Kawamoto S, Nakagawara A, Kato K.
  • Journal Title: BMC Genomics 8 Pages: 206
  • Peer Reviewed
• [Journal Article] Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mc1-1 and exhibiting reduced apoptotic potential in solid tumors. (2006)
  • Author(s): Koshikawa N, Maejima C, Miyazaki K, Nakagawara A, Takenaga K.
  • Journal Title: Oncogene 25 Pages: 917-928
  • Peer Reviewed
• [Journal Article] Biology of neuroblastomas that were found by mass screening at 6 months of age in Japan. (2006)
  • Author(s): Kaneko Y, Kobayashi H, Watanabe N, Tomioka N, Nakagawara A.
  • Journal Title: Pediatr. Blood Cancer 46 Pages: 285-291
  • Peer Reviewed
• [Journal Article] High expression of Aacetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosis. (2006)
  • Author(s): Inamori K, Gu J, Ohira M, Kawasaki A, Nakamura Y, Nakagawa T, Kondo A, Miyoshi E, Nakagawara A, Taniguchi N.
  • Journal Title: FEBS Lett. 580 Pages: 627-632
  • Peer Reviewed
• [Journal Article] Overlapping roles for homeodomain-interacting protein kinases Hipkl and Hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. (2006)
  • Author(s): Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H.
  • Journal Title: Moll. Cell. Biol. 26 Pages: 2758-2771
  • Peer Reviewed
• [Journal Article] Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas. (2006)
  • Author(s): Machida T, Fujita T, Ooo M L, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A.
  • Journal Title: Oncogene 25 Pages: 1931-1942
  • Peer Reviewed
• [Journal Article] Bc1-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma. (2006)
  • Author(s): Niizuma H, Nakamura Y, Ozaki T, Nakanishi H, Ohira M, Isogai E, Kageyama H, Imaizumi M, Nakagawara A.
  • Journal Title: Oncogene 25 Pages: 5046-5055
  • Peer Reviewed
• [Journal Article] Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. (2006)
  • Author(s): Chen H, Suzuki M, Nakamura Y, Ohira M, Ando S, I ida T., Naka j ima T, Nakagawara A, Kimura H.
  • Journal Title: Oncol. Rep. 15 Pages: 1281-1285
  • Peer Reviewed
• [Journal Article] p73-dependent induction of 14-3-3s increases the chemo-sensitivity of drug-resistant human breast cancers. (2006)
  • Author(s): Sang M, Li Y, Ozaki T, Ono S, Ando K, Yamamoto H, Koda T, Geng C, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 347 Pages: 327-333
  • Peer Reviewed
• [Journal Article] p73 and MDM2 confer the resistance of epidermoid carcinoma to cisplatin by blocking p53. (2006)
  • Author(s): Hayashi S, Ozaki T, Yoshida K, Hosoda
  • Journal Title: Biochem. Biophys. Res. Commun. 347 Pages: 60-66
  • Peer Reviewed
• [Journal Article] The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. (2006)
  • Author(s): Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A.
  • Journal Title: Biochem. Biophys. Res. Commun. 351 Pages: 57-63
  • Peer Reviewed
• [Journal Article] NF-kB regulates the stability and activity of p73 by inducing its proteolytic degradation through a ubiquitin-dependent proteasome pathway. (2006)
  • Author(s): Kikuchi H, Ozaki T, Furuya K, Hanamoto T, Nakanishi M, Yamamoto H, Yoshida K, Todo S, Nakagawara A.
  • Journal Title: Oncogene 25 Pages: 7608-7617
  • Peer Reviewed
• [Journal Article] Critical role of PICT1, a tumor suppressor candidate, in phosphatidylinositol 3, 4, 5-triphosphate signals and tumorigenic transformation. (2006)
  • Author(s): Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T.
  • Journal Title: Mol. Biol. Cell 17 Pages: 4888-4895
  • Peer Reviewed
• [Journal Article] Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. (2005)
  • Author(s): Kramer S, Ozaki T, Miyazaki K, Kato C, Hanamoto T, Nakagawara A.
  • Journal Title: Oncogene 24 Pages: 938-944
  • Peer Reviewed
• [Journal Article] CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. (2005)
  • Author(s): Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, Takato T, Nakagawara A, Ushijima T.
  • Journal Title: Cancer Res. 65 Pages: 828-834
  • Peer Reviewed
• [Journal Article] A review of DNA microarray analysis of human neurobl ast omas. (2005)
  • Author(s): Ohira M, Oba S, Nakamura Y, Hirata T, Ishii S, Nakagawara A.
  • Journal Title: Cancer Lett. 228 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Topors, a p53 and topoisomerase I-binding RING finger protein, is a co-activator of p53 in growth suppression induced by DNA damage. (2005)
  • Author(s): Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang J-H, Simonds W, Nakagawara A, Koseki H.
  • Journal Title: Oncogene 24 Pages: 3385-3396
  • Peer Reviewed
• [Journal Article] Functional implication of p73 protein stability in neuronal cell survival and death. (2005)
  • Author(s): Ozaki T, Hosoda M, Miyazaki K, Hayashi S, Watanabe K, Nakagawa T, Nakagawara A.
  • Journal Title: Cancer Lett. 228 Pages: 29-35
  • Peer Reviewed
• [Journal Article] Expression profiling using a tumor-specific cDNA microarray predicts the prognosis of intermediate risk neuroblastomas. (2005)
  • Author(s): Ohira M, Oba S, Nakamura Y, Isogai E, Kaneko S, Nakagawa A, Hirata T, Kubo H, Goto T, Yamada S, Yoshida Y, Fuchioka M, Ishii S, Nakagawara A.
  • Journal Title: Cancer Cell 7 Pages: 337-350
  • Peer Reviewed
• [Journal Article] Identification of protein kinase A catalytic subunit b as a novel binding partner of p73 and regulation of p73 function. (2005)
  • Author(s): Hanamoto T, Ozaki T, Furuya K, Hosoda M, Hayashi S, Nakanishi M, Yamamoto H, Kikuchi H, Todo S, Nakagawara A.
  • Journal Title: J. Biol. Chem. 280 Pages: 16665-16675
  • Peer Reviewed
• [Journal Article] Prediction of MYCN amplification in neuroblastoma using serum DNA and real-time quantitative polymerase chain reaction. (2005)
  • Author(s): Gotoh T, Hosoi H, Iehara T, Kuwahara Y, Osone S, Tsuchiya K, Ohira M, Nakagawara A, Kuroda H, Sugimoto T.
  • Journal Title: J. Clin. Oncol. 23 Pages: 5205-5210
  • Peer Reviewed
• [Journal Article] Biological role of anaplastic lymphoma kinase in neuroblastoma. (2005)
  • Author(s): Osajima-Hakomori Y, Miyake I, Ohira M, Nakagawara A, Nakagawa A, Sakai R.
  • Journal Title: Am Pathol. 167 Pages: 213-222
  • Peer Reviewed
• [Journal Article] LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (2005)
  • Author(s): Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A.
  • Journal Title: Cancer Res. 65 Pages: 4587-4597
  • Peer Reviewed
• [Journal Article] Aberrant methylation of FBN2 in human non-small cell lung cancer. (2005)
  • Author(s): Chen H, Suzuki M, Nakamura Y, Ohira M, Ando S, Iida T, NakajimaT, Nakagawara A, Kimura H.
  • Journal Title: Lung Cancer 50 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Clinical significance of serum NM23-H1 protein in neuroblastoma. (2005)
  • Author(s): Okabe-Kado J, Kasukabe T, Honma Y, Hanada R, Nakagawara A, Kaneko Y.
  • Journal Title: Cancer Sci. 96 Pages: 653-660
  • Peer Reviewed
• [Journal Article] p73, a sophisticated p53 family member in the cancer world. (2005)
  • Author(s): Ozaki T, Nakagawara A.
  • Journal Title: Cancer Sci. 96 Pages: 729-737
  • Peer Reviewed
• [Journal Article] UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiauitination. (2005)
  • Author(s): Hosoda M, Ozaki T, Miyazaki K, Hayashi S, Furuya K, Watanabe K, Nakagawa T, Hanamoto T, Todo S, Nakagawara A.
  • Journal Title: Oncogene 24 Pages: 156-7169
  • Peer Reviewed
• [Journal Article] Meta-analysis of neuroblastomas reveals a skewed ALK mutations spectrum in tumors with MYCN amplification.
  • Author(s): De Brouwer S, De Preter K, Kumps C, Westerhout E, Lakeman A, Hoebeeck J, Van Maerken T, Laureys G, Schulte JH, Noguera R, Delattre O, Janouiex-Lerosey I, Kogner P, Martinsson T, Nakagawara A, Ohira M, Caron H, Eggert A, Versteeg R, Speleman F.
  • Journal Title: J. Glin. Oncol. (Accepted)
  • Peer Reviewed
• [Book] Neuroblastoma(Eds. N-K. Cheung & S. Cohn, Molecular and developmental biology of neuroblastoma., Chapter 5.) (2005)
  • Author(s): Nakagawara A.
  • Total Pages: 41-53
  • Publisher: Springer-Verlag