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2009 Fiscal Year Final Research Report

Molecular understanding and diagnosis of human cancer through the structural, functional and expression analysis of cancer related genes.

Research Project

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Project/Area Number 17015048
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo (2007-2009)
National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East (2005-2006)

Principal Investigator

MURAKAMI Yoshinori  The University of Tokyo, 医科学研究所, 教授 (30182108)

Co-Investigator(Kenkyū-buntansha) MASUDA Mari  国立がんセンター研究所, 研究員 (70435717)
ITO Akihiko  東京大学, 医科学研究所, 准教授 (80273647)
SAKURAI Mika  東京大学, 医科学研究所, 助教 (80508359)
Project Period (FY) 2005 – 2009
Keywordsアレル特異的発現 / RNA difference plot / CADM1 / 非小細胞肺がん / ATL
Research Abstract

For the molecular diagnosis of human cancer, novel molecular targets were identified and a useful technique was developed through the genetic analysis of human cancer cells as well as the host individuals. Using RNA difference plot, a highly quantitative method to identify allele-specific gene expression that we have developed previously, we found that the allele-specific expression of the responsible genes for familial cancer were well correlated with the phenotypic variation in the carriers of the relevant gene mutations. Furthermore, we found that a cell adhesion molecule, CADM1, and its binding partner, 4.1B, act as tumor suppressors in human non-small cell lung cancer and renal clear cell carcinoma, whereas CADM1 was ectopically overexpressed in adult T-cell leukemia (ATL). In ATL, CADM1 associated with Tiam1 and enhanced the cell mobility through activation of Rac, providing a possible molecular cascade for suppressing the invasion of ATL.

  • Research Products

    (65 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (27 results) Presentation (31 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I (HTLV-I) transformed cells and adult T-cell leukemia (ATL) cells.2010

    • Author(s)
      Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y.
    • Journal Title

      Journal of Biological Chemistry 285

      Pages: 15511-15522

  • [Journal Article] Tumor suppressor CADM1 is involved in epithelial cell structure.2009

    • Author(s)
      Sakurai-Yageta M, Masuda M, Tsuboi Y, Ito A, Murakami Y.
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 977-982

  • [Journal Article] Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth.2009

    • Author(s)
      Hagiyama M, Ichiyanagi N., Kimura BK, Murakami Y, Ito A
    • Journal Title

      Am J Pathol. 174

      Pages: 2278-2289

  • [Journal Article] TSLC1 mapped top 11q23 is a candidate tumor suppressor in neuroblastoma.2008

    • Author(s)
      Ando K, Ohira M, Ozaki T, Akazawa K, Suenaga Y, Nakamura Y, Koda T, Kamijo T, Murakami Y, Nakagawara A
    • Journal Title

      Int J Cancer. 123

      Pages: 2087-2094

  • [Journal Article] Identification of SMURF5 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.2008

    • Author(s)
      Suzuki A, Shibata T, Shimada Y, Murakami Y, Horii A, Shiratori K, Hirohashi S, Inazawa J, Imoto I
    • Journal Title

      Cancer Sci. 99

      Pages: 986-994

  • [Journal Article] Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC.2008

    • Author(s)
      Overmeer RM, Snijders PJF, Claassen-Kramer D, Helmerhorst TJM, Berkhof J, Heideman DAM, Wilting SM, Murakami Y, Ito A, Meijer CJLM, Steenbergen RDM
    • Journal Title

      J Pathol. 215

      Pages: 388-397

  • [Journal Article] Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.2008

    • Author(s)
      Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P
    • Journal Title

      J Immunol. 181

      Pages: 2772-2780

  • [Journal Article] Nerve-mast cell and smooth muscle-mast cell interaction mediated by cell adhesion molecule-1, CADM1.2008

    • Author(s)
      Ito A, Hagiyama M, Oonuma J
    • Journal Title

      J Smooth Muscle Res. 44

      Pages: 83-93

  • [Journal Article] Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.2008

    • Author(s)
      Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A
    • Journal Title

      Gastroenterology. 134

      Pages: 1544-1554

  • [Journal Article] Expression of cell adhesion molecule 1 in malignant pleural mesothelioma as a cause of efficient adhesion and growth on mesothelium.2008

    • Author(s)
      Ito A, Hagiyama M, Mimura T, Matsumoto M, Wakayama T, Iseki S, Yokozaki H, Okada M
    • Journal Title

      Lab Invest. 88

      Pages: 504-514

  • [Journal Article] Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells.2007

    • Author(s)
      Wakayama T, Sai Y, Ito A, Kato Y, Kurobo M, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S
    • Journal Title

      Biology Reprod. 76

      Pages: 1081-1090

  • [Journal Article] Role of APRIL (TNSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese.2007

    • Author(s)
      Kawasaki A, Tsuchiya N, Ohashi J, Murakami Y, Fukazawa T, Kusaoi M, Morimoto S, Matsuda K, Hashimoto H, Takasaki Y, Tokunaga K
    • Journal Title

      Rheumatology. 46

      Pages: 776-782

  • [Journal Article] Involvement of the SgIGSF/Necl-2 adhesion molecule in degradation of mesenteric mast cells.2007

    • Author(s)
      Ito A, Hagiyama M, Oonuma J, Murakami Y, Yokozaki H, Takaki M
    • Journal Title

      J Neuro Immunol. 184

      Pages: 209-213

  • [Journal Article] TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma.2006

    • Author(s)
      Lung HL, Kwok A, Cheung L, Xie D, Cheng Y, Murakami Y, Guan X-Y, Sham JS, Chua D, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML
    • Journal Title

      Cancer Res. 66

      Pages: 9385-9392

  • [Journal Article] Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule.2006

    • Author(s)
      Yamada D, Yoshida M, Williams YN, Fukami T, Kikuchi S, Masuda M, Maruyama M, Ohta T, Nakae D, Maekawa A, Kitamura T, Murakami Y
    • Journal Title

      Mol Cell Biol. 26

      Pages: 3610-3624

  • [Journal Article] Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.2006

    • Author(s)
      Weyden LVD, Arends MJ, Chausiaux OE, Lange UC, Surani MA, Affara N, Murakami Y, Adams DJ, Bradley A
    • Journal Title

      Mol Cell Biol. 26

      Pages: 3595-3609

  • [Journal Article] Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary non-small cell lung cancer.2006

    • Author(s)
      Kikuchi S, Yamada D, Fukami T, Maruyama T, Ito A, Asamura H, Matsuno Y, Onizuka M, Murakami Y
    • Journal Title

      Cancer 106

      Pages: 1751-1758

  • [Journal Article] Cell adhesion and prostate tumor suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4.2006

    • Author(s)
      Williams YN, Masuda M, Sakurai-Yageta M, Maruyama T, Shibuya M, Murakami Y
    • Journal Title

      Oncogene. 25

      Pages: 1446-1453

  • [Journal Article] Promoter Hypermethylation of the Potential Tumor Suppressor DAL-1/4.1B Gene in Renal Clear Cell Carcinoma.2006

    • Author(s)
      Yamada D, Kikuchi S, Williams YN, Sakurai-Yageta M, Masuda M, Maruyama T, Tomita K, Gutmann DH, Kakizoe T, Kitamura T, Murakami Y
    • Journal Title

      Int J Cancer. 118

      Pages: 916-923

  • [Journal Article] TSLC (tumor suppressor in lung cancer)1 suppresses epithelial cell scattering and tubulogenesis.2005

    • Author(s)
      Masuda M, Kikuchi S, Maruyama T, Sakurai-Yageta M, Williams YN, Ghosh HP, Murakami Y
    • Journal Title

      J Biol Chem. 280

      Pages: 42164-42171

  • [Journal Article] Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression.2005

    • Author(s)
      Sussan TE, Pletcher MT, Murakami Y, Reever RH
    • Journal Title

      Mol Cancer. 4

      Pages: 28

  • [Journal Article] Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis.2005

    • Author(s)
      Kuroki K, Tsuchiya N, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukuzawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, Tokunaga K
    • Journal Title

      Hum Mol Genet. 14

      Pages: 2469-2480

  • [Journal Article] Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis.2005

    • Author(s)
      Murakami Y
    • Journal Title

      Cancer Sci. 96

      Pages: 543-552

  • [Journal Article] Loss of TSLC expression in lung adencarcinoma : relationships with histological subtypes, gender, and prognostic significance.2005

    • Author(s)
      Goto A, Niki T, Chi-pin L, Matsubara D, Murakami Y. Funata N, Fukayama M
    • Journal Title

      Cancer Sci. 96

      Pages: 480-486

  • [Journal Article] Promoter methylation of the DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer.2005

    • Author(s)
      Kikuchi S, Yamada D, Fukami T, Masuda M, Sakurai-Yageta M, Williams YN, Maruyama T, Asamura H, Matsuno Y, Onizuka M, Murakami Y
    • Journal Title

      Clin Cancer Res. 11

      Pages: 2954-2961

  • [Journal Article] A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.2005

    • Author(s)
      Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y , Tsunoda T, Notoya K, Nakamura Y, Ikegawa S
    • Journal Title

      Hum Mol Genet. 14

      Pages: 1009-1017

  • [Journal Article] Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute type of adult T-cell leukemia.2005

    • Author(s)
      Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Ishida Y, Fukami T, Hidaka T, Kubuki Y, Okayama A, Hamada K, Okabe H, Murakami Y
    • Journal Title

      Blood. 105

      Pages: 1204-1213

  • [Presentation] Possible function of a cell adhesion molecule, CADM1, as a dependence receptor2010

    • Author(s)
      Murakami Y.
    • Organizer
      The 4^<th> Dependence Receptor Meeting
    • Place of Presentation
      フランス国、ニース市
    • Year and Date
      20100322-20100326
  • [Presentation] Involvement of a cell adhesion molecule CADM1/TSLC1 in oncogenesis2010

    • Author(s)
      Nagata M, Sakurai-Yageta M, Kawai T, Ito T, Ito A, Yoshida M, Murakami Y.
    • Organizer
      The 8^<th> AACR-JCA Joint Conference on Cancer Research
    • Place of Presentation
      米国、ハワイ島
    • Year and Date
      20100205-20100210
  • [Presentation] Involvement of a cell adhesion molecule CADM1/TSLC1 in oncogenesis2010

    • Author(s)
      Nagata M, Sakurai-Yageta M, Masuda M, Tsuboi Y, Iwai M, Kawai T, Murakami S, Ito T, Ito A, Murakami Y.
    • Organizer
      The 15^<th> Charles Heidelberger International Symposium on Cancer Research
    • Place of Presentation
      タイ国、ピサヌロック市
    • Year and Date
      20100118-20100121
  • [Presentation] Dynamics of CADM1 protein in the membrane of stable adhesion and in the process of cell-cell contact formation2009

    • Author(s)
      櫻井(八下田)美佳、丸山智子、村上善則
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      20091209-20091212
  • [Presentation] Proteomic analysis of cell adhesion molecule 1 (CADM1) complex2009

    • Author(s)
      坪井裕見、伊藤彰彦、村上善則
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      20091209-20091212
  • [Presentation] Suppression of excessive glucagon secretion from pancreatic islet α cells by cell adhesion molecule-1-mediated gap junction formation2009

    • Author(s)
      一柳直希、伊藤彰彦、村上善則
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      20091209-20091212
  • [Presentation] Involvement of a cell adhesion molecule CADM1/TSLC1 in oncogenesis2009

    • Author(s)
      Nagata M, Sakurai-Yageta M, Masuda M, Tsuboi Y, Iwai M, Kawai T, Murakami S, Ito T, Ito A, Murakami Y.
    • Organizer
      The First Formosan Symposium on Structural Biology of Membrane Proteins and Biomembranes
    • Place of Presentation
      台湾、台北市
    • Year and Date
      20091209-20091210
  • [Presentation] Involvement of a cell adhesion molecule CADM1/TSLC1 in oncogenesis2009

    • Author(s)
      村上善則
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜市
    • Year and Date
      20091001-20091003
  • [Presentation] Estimation of intercellular adhesive strength using laser-induced impulsive force under general culture condition2009

    • Author(s)
      伊藤彰彦、萩山満、村上善則
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜市
    • Year and Date
      20091001-20091003
  • [Presentation] Mechanism of transcriptional regulation of the CADM1 gene during the neural differentiation of murine embryonal carcinoma cells, P19, induced by retinoic acid2009

    • Author(s)
      伊東剛、桜井美佳、村上善則
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜市
    • Year and Date
      20091001-20091003
  • [Presentation] Expression of a soluble form of CADM1 in the brain and its involvement in directional neurite outgrowth2009

    • Author(s)
      萩山満、一柳直希、伊藤彰彦、村上善則
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜市
    • Year and Date
      20091001-20091003
  • [Presentation] がんの遺伝子・ゲノム研究の意義と家族性腫瘍2009

    • Author(s)
      村上善則
    • Organizer
      日本癌治療学会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-23
  • [Presentation] Involvement of a tumor suppressor CADM1/TSLC1 in lung tumorigenesis.2008

    • Author(s)
      Murakami Y.
    • Organizer
      The 13th Japan-Korea Cancer Research Workshop. Symposium.
    • Place of Presentation
      韓国、大田市
    • Year and Date
      20081212-20081214
  • [Presentation] 非小細胞肺がんでは CADM1/TSLC1、4.1Bのメチル化による不活化と、EGFR、KRAS2の変異は独立して生じる2008

    • Author(s)
      尾鼻孝滋、菊池慎二、丸山智子、坪井裕見、伊藤彰彦、浅村尚生、金井弥栄、村上善則
    • Organizer
      第67回日本癌学会総会 口頭発表
    • Place of Presentation
      名古屋
    • Year and Date
      20081028-20081030
  • [Presentation] 新規膵島細胞接着分子CADM1は神経-島細胞相互作用を促進し、膵島細胞腫瘍のホルモン機能性に関与する2008

    • Author(s)
      伊藤彰彦、萩山満、村上善則
    • Organizer
      第67回日本癌学会総会 口頭発表
    • Place of Presentation
      名古屋
    • Year and Date
      20081028-20081030
  • [Presentation] 細胞接着分子CADM1/TSLC1の異常による肺腫瘍形成の分子機構2008

    • Author(s)
      村上善則、櫻井(八下田)美佳、永田政義、坪井裕見、岩井美和子、尾鼻孝滋、伊藤彰彦
    • Organizer
      第67回日本癌学会総会 シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      20081028-20081030
  • [Presentation] 非小細胞肺がんではCADM1/TSLC1、4.1Bのメチル化による不活化と、EGFR、KRAS2の変異は独立して生じる2008

    • Author(s)
      尾鼻孝滋、菊池慎二、丸山智子、坪井裕見、伊藤彰彦、浅村尚生、金井弥栄、村上善則
    • Organizer
      第53回日本人類遺伝学会大会 口頭発表
    • Place of Presentation
      横浜
    • Year and Date
      20080927-20080930
  • [Presentation] がんオミックス研究の現状2008

    • Author(s)
      村上善則
    • Organizer
      第53回日本人類遺伝学会大会 シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      20080927-20080930
  • [Presentation] Involvement of a cell adhesion molecule, CADM1/TSLC1 in lung oncogenesis.2008

    • Author(s)
      Murakami Y.
    • Organizer
      The 14th Internatioal Charles Heidelberger Symposium on Cancer Research. Invited speaker.
    • Place of Presentation
      中国、ウルムチ市
    • Year and Date
      20080919-20080925
  • [Presentation] がん抑制遺伝子CADM1/TSLC1による肺がん抑制機構の解析2008

    • Author(s)
      村上善則、永田政義、尾鼻孝滋、菊池慎二、櫻井(八下田)美佳、坪井裕見、岩井美和子、伊藤彰彦
    • Organizer
      第23回日本肺癌学会ワークショップ シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-19
  • [Presentation] がん抑制蛋白質TSLC1/CADM1による上皮様形態形成と腫瘍抑制の分子機構の解析2007

    • Author(s)
      桜井(八下田)美佳、坪井裕見、増田万里、山田大介、永田政義、尾鼻孝滋、村上善則
    • Organizer
      第30回日本分子生物学会年会 シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      20071211-20071215
  • [Presentation] 成人T細胞白血病(ATL)において細胞接着分子TSLC1.CADM1が惹起する低分子量G蛋白質Racの活性化とその下流分子の解析2007

    • Author(s)
      増田万里、増田智子、伊藤彰彦、大田力、村上善則
    • Organizer
      第30回日本分子生物学会年会 示説
    • Place of Presentation
      横浜
    • Year and Date
      20071211-20071215
  • [Presentation] Involvement of a cell adhesion molecule, TSLC1/CADM1, in lung tumorigenesis.2007

    • Author(s)
      Nagata M, Obana T, Sakurai-Yageta M, Tsuboi Y, Yamada D, Masuda M, Ichihara H, Masuda T, Murakami, Y.
    • Organizer
      International Sympoisum on Cell Polarity and Future Medicine示説
    • Place of Presentation
      葉山
    • Year and Date
      20071209-20071210
  • [Presentation] Involvement of a cell adhesion molecule, TSLC1/CADM1, in lung tumorigenesis.2007

    • Author(s)
      Nagata M, Obana T, Tsuboi, Y, Sakurai-Yageta, M, Masuda, T, Ichihara, H, Murakami, Y.
    • Organizer
      The 14th East Asia Joint Symposium on Biomedical Research シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      20071113-20071114
  • [Presentation] Male infertility and spontaneous development of lung tumor in mice lacking the tumor suppressor gene, Tslc1/Cadm1.2007

    • Author(s)
      Nagata M, Yamada D, Obana T, Masuda M, Ichihara H, Maruyama T, Yoshida M, Tsutsumi M, Murakami Y.
    • Organizer
      日本癌学会 口演
    • Place of Presentation
      横浜
    • Year and Date
      20071003-20071005
  • [Presentation] TSLC1/CADM1 induces lamellipodia formation through activation of Rac in the HTLV-1 infected T cells and the ATL cells.2007

    • Author(s)
      Masuda M, Kikuchi S, Maruyama T, Ito A, Murakami Y.
    • Organizer
      日本癌学会 口演
    • Place of Presentation
      横浜
    • Year and Date
      20071003-20071005
  • [Presentation] TSLC1 mapped to 11q23 is candidate tumor suppressor in neuroblastoma.2007

    • Author(s)
      Ando K, Ohira M, Ozaki T, Koide K, Kageyama H, Nakagawa A, Akazawa K, Murakami Y, Nakagawara A.
    • Organizer
      日本癌学会 口演
    • Place of Presentation
      横浜
    • Year and Date
      20071003-20071005
  • [Presentation] 肺癌の発生、進展に関わる癌抑制遺伝子TSLC1/CADM12007

    • Author(s)
      村上善則
    • Organizer
      第52回日本人類遺伝学会大会 シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      20070912-20070915
  • [Presentation] Involvement of a Tumor Suppressor TSLC1/CADM1 in Lung Tumorigenesis in Human and the Gene-deficient Mice.2007

    • Author(s)
      Murakami Y, Kikuchi S, Yamada D, Nagata M, Obana T, Masuda M, Tsuboi Y, Usui S,, Ichihara H, Maruyama T.
    • Organizer
      The 12th World Conference on Lung Cancer 口演
    • Place of Presentation
      韓国京城市
    • Year and Date
      20070902-20070905
  • [Presentation] TSLC1 induces lamellipodia formation through activation of Rac in the HTLV-1 infected T cells and the ATL cells.2007

    • Author(s)
      Masuda M, Kikuchi S, Maruyama T, Ito A, Murakami Y.
    • Organizer
      The 13th International Conference in Human retrovirology. HTLV-1 and related viruses 口演
    • Place of Presentation
      箱根
    • Year and Date
      20070522-20070525
  • [Presentation] ヒト家族性腫瘍のモデルとしてのTslc1/Cadm1遺伝子欠損マウスの解析2007

    • Author(s)
      山田大介、永田政義、尾鼻孝滋、増田万里、市原博美、増田智子、吉田緑、堤雅弘、北村唯一、村上善則
    • Organizer
      第12回家族性腫瘍学会
    • Place of Presentation
      高知
    • Year and Date
      2007-06-16
  • [Remarks] ホームページ

  • [Remarks] 東京大学医科学研究所 癌・細胞増殖部門人癌病因遺伝子分野

    • URL

      http://www.ims.u-tokyo.ac.jp/hitogan/index.Html

  • [Remarks] 読売新聞、2006年8月6日、朝刊14面

  • [Remarks] がん抑制遺伝TSLC1不妊・ぜんそくにも関連

  • [Patent(Industrial Property Rights)] 小細胞肺がんの診断のための方法、システムおよび組成物ならびに関連するスクリーニング方法2008

    • Inventor(s)
      村上善則
    • Industrial Property Rights Holder
      国立がんセンター
    • Industrial Property Number
      PCT,PCT/JP2006/325937号
    • Filing Date
      2008-06-28
  • [Patent(Industrial Property Rights)] 小細胞肺がんの診断のための方法、システムおよび組成物ならびに関連するスクリーニング方法2005

    • Inventor(s)
      村上善則
    • Industrial Property Rights Holder
      国立がんセンター
    • Industrial Property Number
      特願2005-380332
    • Filing Date
      2005-12-28
  • [Patent(Industrial Property Rights)] がんの診断、処置および/または予防、および/または浸潤・転移の抑制のための方法2005

    • Inventor(s)
      村上善則、増田万里
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団
    • Industrial Property Number
      特願2005-266127
    • Filing Date
      2005-09-13

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Published: 2012-02-13   Modified: 2016-04-21  

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