EP-DEMIOLOGICAL STUDY ONENVIRONMENTAL AND HOST-SPECIFIC FACT0RS FOR INCREASING CANCERS IN JAPAN, CHINA AND KOREA

2009 Fiscal Year Final Research Report

• Project/Area Number: 17015052
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: TAJIMA Kazuo Aichi Cancer Center Research Institute, 所長 (30150212)
• Co-Investigator(Kenkyū-buntansha): TANAKA Hideo 愛知県がんセンター(研究所), 疫学・予防部, 部長 (60470168) ; MATSUO Keitaro 愛知県がんセンター(研究所), 疫学・予防部, 室長 (80393122) ; KAWASE Takakazu 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (30463194) ; TAKEZAKI Toshiro 鹿児島大学, 大学院・医歯学総合研究科, 教授 (50227013) ; HIROSE Kaoru 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (00393124) ; ITO Hidemi 愛知県がんセンター(研究所), 疫学・予防部, 研究員 (90393123) ; TOKUDOME Yuko 名古屋文理大学, 健康生活学部, 教授 (90132472) ; CHIBA Hitoshi 北海道大学, 教授 (70197622) ; WAKAI Kenji 名古屋大学, 大学院・医学系研究科, 准教授 (50270989) ; HIRAKI AOkio 愛知県がんセンター(研究所), 疫学・予防部, 室長 (70443455) ; SUZUKI Takeshi 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (70416163) ; MASUI Tohru 医薬基盤研究所, 主任研究員 (50150082)
• Project Period (FY): 2005 – 2009
• Keywords: 乳・大腸がん / 民族疫学 / 環境・宿主交互作用 / がん予防 / 国際研究交流

Research Abstract

乳・大腸がんは日・中・韓三国で増加しつつあり、その環境・宿主要因を分子疫学的に解明し、三国における予防対策に寄与することを本研究課題の主目的と定め、平成17年度より五年計画で第二次三国共同研究を推進した。乳・大腸がんの三国における一般的増加要因を確認し、さらに、乳がんでは十分な大豆製品や葉酸の摂取が危険度を下げ、遺伝的にFGFR2の過剰発現群では肥満傾向や角経早期開始などの影響が大きいことなどを鮮明にした。

Research Products

• [Journal Article] Association between CYP7A1 loci and the risk of proximal colon cancer. (2010)
  • Author(s): Ito H, Matsuo K, Hosono S, Watanabe M, Kawase T, Suzuki T, Hirai T, Yatabe Y, Tanaka H, Tajima K.
  • Journal Title: Int J Mol Epi Genet (in press) Pages: 22-26
• [Journal Article] FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: Results of acase control study in Japan (2009)
  • Author(s): Kawase T, Matsuo K, Suzuki T, Hiraki A, Watanabe M, Iwata H, Tanaka H, Tajima K.
  • Journal Title: Int J Cancer 125(8) Pages: 1946-1952
• [Journal Article] Association between an 8q24 locus and the risk of colorectal cancer in Japanese (2009)
  • Author(s): Matsuo K, Suzuki T, Ito H, Hosono S, Kawase T, Watanabe M, Shitara K, Komori K, Kanemitsu Y, Hirai T, Yatabe Y, Tanaka H, Tajima K.
  • Journal Title: BMC Cancer 9 Pages: 379
• [Journal Article] A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population (2009)
  • Author(s): Yang H, Zhou Y, Zhou Z, Liu J, Yuan X, Matsuo K, Takezaki T, Tajima K, Cao J.
  • Journal Title: Cancer Epidemiol Bio-markers Prev 18(9) Pages: 2522-2527
• [Journal Article] Body size, physical activity and risk of breast cancer-A case control study in Jangsu Province of China (2009)
  • Author(s): Gao CM, Tajima K, Ding JH, Tang JH, Wu JZ, Li SP, Cao HX, Liu YT, Su P, Qian Y, Chang J, Takezaki T.
  • Journal Title: Asian Pacific J Cancer Prev 10 Pages: 1-6
• [Journal Article] MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese woman (2009)
  • Author(s): Gao CM, Tang JH, Cao HX, Ding JH, Wu JZ, Wang J, Liu YH, Li SP, Su P, Matsuo K, Takezaki T, Tajima K.
  • Journal Title: J Hum Genet 54(7) Pages: 414-418
• [Journal Article] One-carbon metabolism-related gene polymorphisms and risk of breast cancer risk (2008)
  • Author(s): Suzuki T, Matsuo K, Hirose K, Hiraki A, Kawase T, Watanabe M, Yamashita T, Iwata H, Tajima K.
  • Journal Title: Cancer Epidemiol Biomarkers Prev 17 Pages: 2742-2747
• [Journal Article] Effect of soybean on breast cancer according to receptor status: a case-control study in Japan (2008)
  • Author(s): Suzuki T, Matsuo K, Tsunoda N, Hirose K, Hiraki A, Kawase T, Yamashita T, Iwata H, Tanaka H, Tajima K.
  • Journal Title: Int J Cancer 123 Pages: 1674-1680
• [Journal Article] enetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer (2008)
  • Author(s): Cao HX, Gao CM, Takezaki T, Wu JZ, Ding JH, Liu YT, Li SP, Su P, Cao J, Hamajima N, Tajima K.
  • Journal Title: Asian Pac J Cancer Prev 9(2) Pages: 203-208
• [Journal Article] Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males (2008)
  • Author(s): Gao CM, Takezaki T, Wu JZ, Chang XM, Cao HC, Ding JH, Liu YT, Li SP, Cao J, Matsuo K, Hamajima N, Tajima K.
  • Journal Title: W J Gastroenterol 14 Pages: 5078-5083
• [Journal Article] Dietary patterns and the risk of breast cancer in Japanese women (2007)
  • Author(s): Hirose K, Matsuo K, Iwata H, Tajima K
  • Journal Title: Cancer Sci 98 Pages: 1431-1438
• [Journal Article] Breast cancer risk and erythrocyte composi-tions of n-3 highly unsaturated fatty acids in Japanese (2007)
  • Author(s): Kuriki K, Hirose K, Wakai K, Matsuo K, Ito H, Suzuki T, Hiraki A, Saito T, Iwata H, Tatematsu M, Tajima K.
  • Journal Title: Int J Cancer 121 Pages: 377-385
• [Journal Article] Decreased risk of colorectal cancer with the high Natural-Killer (NK)-cell activity NKG2D genotype in Japanese (2007)
  • Author(s): Furue H, Matsuo K, Kumimoto H, Hiraki A, Suzuki T, Yatabe Y, Komori K, Kanemitsu Y, Hirai T, Kato T, Ueda M, Ishizaki K, Tajima K.
  • Journal Title: Carcinogenesis 29 Pages: 316-320
• [Journal Article] CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer associated with smoking and alcohol drinking World (2007)
  • Author(s): Gao CM, Takezaki T, Wu JZ, Chen MB, Liu YT, Ding JH, Sugimura H, Cao J, Hamajima N, Tajima K.
  • Journal Title: J Gastroenterol 13(43) Pages: 5725-5730
• [Journal Article] Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat and fatty acids. (2006)
  • Author(s): Kuriki K, Wakai K, Hirose K, Matsuo K, Ito H, Suzuki T, Saito T, Kanemitsu Y, Hirai T, Kato T, Tatematsu M, Tajima K.
  • Journal Title: Cancer Epidemiol. Biomarker Prev 15 Pages: 1791-1798
• [Journal Article] Meat, milk, saturated fatty acids, the Prol2Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese (2006)
  • Author(s): Kuriki K, Hirose K, Matsuo K, Wakai K, Ito H, Kanemitsu Y, Hirai T, Kato T, Hamajima N, Takezaki T, Suzuki T, Saito T, Tanaka R, Tajima K.
  • Journal Title: Cancer Sci 97 Pages: 1226-1235
• [Journal Article] The Increasing incidence of colorectal cancer and the preventive strategy in Japan (2006)
  • Author(s): Kuriki K, Tajima K.
  • Journal Title: Asian Pac J Cancer Prev 7 Pages: 495-501
• [Journal Article] A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan (2006)
  • Author(s): Matsuo K, Ito H, Wakai K, Hirose K, Saito T, Suzuki T, Kato T, Hirai T, Kanemitsu Y, Hamajima H, Tajima K.
  • Journal Title: Carcinogenesis 27 Pages: 1018-1023
• [Journal Article] Dietary risk factors for colon and rectal cancers: a comparative case-control study (2006)
  • Author(s): Wakai K, Hirose K, Matsuo K, Ito H, Kuriki K, Suzuki T, Kato T, Hirai T, Kanemitsu Y, Tajima K.
  • Journal Title: J Epidemiol 16 Pages: 125-135
• [Journal Article] An intervention study of smoking cessation with feedback on genetic cancer susceptibility (2006)
  • Author(s): Ito H, Matsuo K, Wakai K, Saito T, Kumimoto H, Okuma K, Tajima K, Hamajima N.
  • Journal Title: Prev Med 42 Pages: 102-108
• [Journal Article] Genetic polymorphisms of interleukin-1 (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women (2006)
  • Author(s): Lee KM, Park SK, Hamajima N, Tajima K, Choi JY, Noh DY, Ahn SH, Yoo KY, Hirvonen A, Kang D.
  • Journal Title: Breast Cancer Res Tr 96 Pages: 197-202
• [Journal Article] Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with special reference to the aldehyde dehydro-genase 2 gene G1u4871ys polymorphism and drinking habit (2005)
  • Author(s): Kuriki K, Hamajima N, Chiba H, Kanemitsu Y, Hirai T, Kato T, Saito T, Matuso K, Koike K, Tokudome S, Tajima K.
  • Journal Title: Asian Pacific J Cancer Prev 6 Pages: 62-68
• [Journal Article] Increased risk of colorectal cancer due to the interaction between meat consumption and the CD36 gene A52C polymorphism among Japanese (2005)
  • Author(s): Kuriki K, Hamajima N, Chiba H, Kanemitsu Y, Hirai T, Kato T, Saito T, Matuso K, Koike K, Tokudome S, Tajima K.
  • Journal Title: NUTR CANCER 51 Pages: 170-177
• [Journal Article] Soybean products and reduction of breast cancer risk: a case-control study in Japan (2005)
  • Author(s): Hirose K, Imaeda N, Tokudome Y, Goto C, Wakai K, Matsuo K, Ito H, Toyama T, Iwata H, Tokudome S, Tajima K
  • Journal Title: Brit J Cancer 93 Pages: 15-22
• [Journal Article] One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan (2005)
  • Author(s): Matsuo K, Ito H, Wakai K, Hirose K, Saito T, Suzuki T, Kato T, Hirai T, Kanemitsu Y, Hamajima H, Tajima K.
  • Journal Title: Carcinogenesis 26 Pages: 2164-2171
• [Journal Article] Relative validity of a short food frequency questionnaire for assessing nutrient intake versus three-day weighed diet records in middle-aged Japanese (2005)
  • Author(s): Tokudome Y, Goto C, Imaeda N, Hasegawa T, Kato R, Hirose K, Tajima K, Tokudome S.
  • Journal Title: J Epidemiol 15 Pages: 135-145
• [Journal Article] Development of a semi-quantitative food frequency questionnaire for middle-agaed inhab-itants in the Chaoshan area (2005)
  • Author(s): Song F-Y, Takezaki T, Li K, Yu P, Lin X-K, Yang H-L, Deng X-L, Zhang Y-Q, Huang X-E, Tajima K.
  • Journal Title: China. World Castroenterol 11 Pages: 4078-4084
• [Journal Article] Genetic polymorphism of TGF-B1 & TNF-B and breast cancer ris (2005)
  • Author(s): Lee K M, Park S K, Hamajima N, Tajima K, Yoo K Y, Shin A, Noh D Y, Ahn S H, Hiroven A, Kang D.
  • Journal Title: Breast Cancer Res 90 Pages: 149-155
• [Presentation] Sufficient folate intake and possible risk reduction of colorectal and breast cancer in Asia (2010)
  • Author(s): Tajima K.
  • Organizer: 15th Charles Heidelberger International Symposium in Cancer Research
  • Place of Presentation: Phitsanulok, Thailand.
  • Year and Date: 2010-01-18
• [Presentation] The role of cancer research in cancer control program (2009)
  • Author(s): TajimaK
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] ゲノム疫学の光と陰 (2008)
  • Author(s): 田島和雄
  • Organizer: 第18回日本疫学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-25
• [Presentation] Asian cancer etiology and prevention (2007)
  • Author(s): Tajima K
  • Organizer: Asian Medical Forum The Lancer 2007
  • Place of Presentation: Singapore
  • Year and Date: 2007-04-21
• [Presentation] Advantages and disadvantages of comparative ethnoepidemiologic studies on increasing colorectal and breast cancers focusing on Korea, Japan and China (KOJACH study) (2006)
  • Author(s): Tajima K
  • Organizer: 3rd APOCP General Assembly Conference
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2006-11-04
• [Presentation] Epidemic patterns and prevention strategies for GI tract cancers in the Asian Pacific (2005)
  • Author(s): Tajima K
  • Organizer: 3rd Regional Conference of APOCP
  • Place of Presentation: Rasht, Iran
  • Year and Date: 2005-04-25
• [Remarks]
  • URL: http://www.ref.aichi./cancer-center/400/420/421/421-Ol.html