NKT cell-based immunotherapy for cancer

2009 Fiscal Year Final Research Report

• Project/Area Number: 17016010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Chiba University
• Principal Investigator: NAKAYAMA Toshinori Chiba University, 大学院・医学研究院, 教授 (50237468)
• Co-Investigator(Kenkyū-buntansha): KIMURA Motoko 千葉大学, 大学院・医学研究院, 助手 (00345018)
• Project Period (FY): 2005 – 2009
• Keywords: 免疫学 / 発生・分化 / 癌 / トランスレーショナルリサーチ / 糖鎖

Research Abstract

To evaluate the safety, immune responses and antitumor responses after the administration of α-Galactosylceramide (αGalCer; KRN7000)-pulsed APCs, a phase I-II study in patients with non-small cell lung cancer (NSCLC) was carried out. αGalCer-pulsed APCs (1x10 9/m2) were intravenously administered four times to 17 cases. The estimated median survival time (MST) of the 17 cases was 18.6 months. Ten patients who displayed increased IFN-g producing cells (≥2 fold) showed prolonged MST (31.9 months) as compared to poor-responder patients (n=7, 9.7 months). The administration of αGalCer-pulsed APCs was well tolerated and was accompanied by the successful induction of NKT cell-dependent immune responses. These results are encouraging and warrant further evaluation for survival benefit of this immunotherapy.

Research Products

• [Journal Article] Organization of immunological memory by bone marrow stroma. (2010)
  • Author(s): Tokoyoda, K., Hauser A.E., Nakayama, T., Radbruch, A.
  • Journal Title: N a t. R e v. I m m u n o l. 10 Pages: 193-200
  • Peer Reviewed
• [Journal Article] Color-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model. (2010)
  • Author(s): Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R.M., Shirai, M., Nakayama, T.
  • Journal Title: J Allergy Clin. I m m u n o l. 125 Pages: 461-468.e6
  • Peer Reviewed
• [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation. (2009)
  • Author(s): Miki, H.T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 183 Pages: 8203-8215
  • Peer Reviewed
• [Journal Article] The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. (2009)
  • Author(s): Kohu, K., Ohmori, H., Wong, W.F., Onda, D., Wakoh, T., Kon, S., Yamashita, M., Nakayama, T., Kubo, M., Satake, M.
  • Journal Title: J. Immunol. 183 Pages: 7817-7824
  • Peer Reviewed
• [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. (2009)
  • Author(s): Kitajima, M., Iwamura, C., Miki, H.T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 183 Pages: 5388-5396
  • Peer Reviewed
• [Journal Article] Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. (2009)
  • Author(s): Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T., Okamoto, Y.
  • Journal Title: C a n c e r S c i. 100 Pages: 1092-1098
  • Peer Reviewed
• [Journal Article] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. (2009)
  • Author(s): Nakayama, T., Yamashita, M.
  • Journal Title: S e m i n. I m m u n o l. 21 Pages: 78-83
  • Peer Reviewed
• [Journal Article] Natural killer T cell-mediated immunotherapy for malignant diseases. (2009)
  • Author(s): Motohashi, S., Nakayama, T.
  • Journal Title: F r o n t i e r s i n B i o s c i e n c e S1 Pages: 108-116
  • Peer Reviewed
• [Journal Article] Invariant natural killer T cell -based immunotherapy for cancer. (2009)
  • Author(s): Motohashi, S., Nakayama, T.
  • Journal Title: I m m u n o t h e r a p y 1 Pages: 73-82
  • Peer Reviewed
• [Journal Article] A phase I-II study of α-Galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non -small cell lung cancer. (2009)
  • Author(s): Motohashi, S., Nagato, K., Kunii, N., Yamamoto, H., Yamasaki, K., Okita, K., Hanaoka, H., Shimizu, N., Suzuki, M., Yoshino, I., Taniguchi, M., Fujisawa, T., Nakayama, T.
  • Journal Title: J. Immunol. 182 Pages: 2492-2501
  • Peer Reviewed
• [Journal Article] A novel subset of mouse NKT cells bearing the IL -17 receptor B responds to IL -25 and contributes to airway hyperreactivity. (2008)
  • Author(s): Terashima, A., Watarai, H., Inoue, S., Sekine, E., Nakagawa, R., Hase, K., Iwamura, C., Nakajima, H., Nakayama, T., Taniguchi, M.
  • Journal Title: J. E x p. M e d. 205 Pages: 2727-2733
  • Peer Reviewed
• [Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. (2008)
  • Author(s): Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S., Nakayama, T.
  • Journal Title: J. Biol. Chem. 283 Pages: 28216-28225
  • Peer Reviewed
• [Journal Article] Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. (2008)
  • Author(s): Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., Nakayama, T.
  • Journal Title: J. Allergy C l i n. Immunol. 122 Pages: 512-520.e11
  • Peer Reviewed
• [Journal Article] Development and characterization of IL-21-producing CD4+ T cells. (2008)
  • Author(s): Suto, A., Kashiwakuma, D., Kagami, S., Hirose, K., Watanabe, N., Yokote, K., Saito, Y., Nakayama, T., Grusby, J.M., Iwamoto, I., Nakajima, H.
  • Journal Title: J. Exp. M e d. 205 Pages: 1369-1379
  • Peer Reviewed
• [Journal Article] Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. (2008)
  • Author(s): Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I., Nakayama, T.
  • Journal Title: I n t. I m m u n o l. 20 Pages: 849-860
  • Peer Reviewed
• [Journal Article] Initiation and maintenance of Th2 cell identity. Truncated title: Regulation of Th2 responses. (2008)
  • Author(s): Nakayama, T., Yamashita, M.
  • Journal Title: C u r r. O p i n. I m m u n o l. 20 Pages: 265-271
  • Peer Reviewed
• [Journal Article] Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. (2008)
  • Author(s): Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., Nakayama, T.
  • Journal Title: J. Exp. Med. 205 Pages: 1109-1120
  • Peer Reviewed
• [Journal Article] Clinical applications of natural killer T cell-based immunotherapy for cancer. (2008)
  • Author(s): Motohashi, S., Nakayama, T.
  • Journal Title: C a n c e r S c i. 99 Pages: 638-645
  • Peer Reviewed
• [Journal Article] Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus. (2008)
  • Author(s): Kitajima, M., Abe, T., Miyano, K.N., Taniguchi, M., Nakayama, T., Takaku, H.
  • Journal Title: M o l. Ther. 16 Pages: 261-268
  • Peer Reviewed
• [Journal Article] Phase I study of α- galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. (2008)
  • Author(s): Uchida, T., Horiguchi, S., Tanaka, Y., Yamamoto, H., Kunii, N., Motohashi, S., Taniguchi, M., Nakayama, T., Okamoto, Y.
  • Journal Title: C a n c e r I m m u n o l. Immunother. 57 Pages: 337-345
  • Peer Reviewed
• [Journal Article] Immune mechanisms of allergic airway diseases: Regulation by transcription factors. (2007)
  • Author(s): Yamashita, M., Onodera, A., Nakayama, T.
  • Journal Title: C r i t. Rev. Immunol. 27 Pages: 539-546
  • Peer Reviewed
• [Journal Article] Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. (2007)
  • Author(s): Kimura, Y.M., Iwamura, C., Suzuki, A., Miki, T., Hasegawa, A., Sugaya, K., Yamashita, M., Ishii, S., Nakayama, T.
  • Journal Title: J. I m m u n o l. 178 Pages: 4926-4936
  • Peer Reviewed
• [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. (2007)
  • Author(s): Kaneko, T., Hosokawa, H., Yamashita, M., Wang, C.R., Hasegawa, A., Kimura, Y.M., Kitajima, M., Kimura, F., Miyazaki, M., Nakayama, T.
  • Journal Title: M o l. I m m u n o l. 44 Pages: 2249-2256
  • Peer Reviewed
• [Journal Article] IL-21-induced Be cell apoptosis mediated by natural killer T cells suppresses IgE responses. (2006)
  • Author(s): Harada, M., Magara, K.K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., Yeh, W.C., Akira, S., Kitamura, H., Ohara, O., Seino, K., Taniguchi, M.
  • Journal Title: J. E x p. M e d. 203 Pages: 2929-2937
  • Peer Reviewed
• [Journal Article] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. (2006)
  • Author(s): Hosokawa, H., Kimura, Y.M., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 177 Pages: 7656-7664
  • Peer Reviewed
• [Journal Article] Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. (2006)
  • Author(s): Shinnakasu, R., Yamashita, M., Shinoda, K., Endo, Y., Hosokawa, H., Hasegawa, A., Ikemizu, S., Nakayama, T.
  • Journal Title: J. I m m u n o l. 177 Pages: 5801-5810
  • Peer Reviewed
• [Journal Article] A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer. (2006)
  • Author(s): Motohashi, S., Ishikawa, A., Ishikawa, E., Otsuji, M., Iizasa, T., Hanaoka, H., Shimizu, N., Horiguchi, S., Okamoto, Y., Fujii, S., Taniguchi, M., Fujisawa, T., Nakayama, T.
  • Journal Title: C l i n. C a n. R e s. 12 Pages: 6079-6086
  • Peer Reviewed
• [Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. (2006)
  • Author(s): Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, Y.M., Hasegawa, A., Nakayama, T.
  • Journal Title: I m m u n i t y 24 Pages: 611-622
  • Peer Reviewed
• [Journal Article] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. (2006)
  • Author(s): Hasegawa, A., Miki, T., Hosokawa, H., Hossain, M.B., Shimizu, C., Hashimoto, K., Kimura, Y.M., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 176 Pages: 2546-2554
  • Peer Reviewed
• [Journal Article] Regulation of allergic airway inflammation through Toll -like receptor 4-mediated modification of mast cell function. (2006)
  • Author(s): Nigo, I.Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., Nakayama, T.
  • Journal Title: P r o c. N a t l. A c a d. S c i. U S A 103 Pages: 2286-2291
  • Peer Reviewed
• [Journal Article] Accelerated chemically-induced tumor development mediated by CD4+ CD25+ regulatory T cells in wild-type hosts. (2005)
  • Author(s): Nishikawa, H., Kato, T., Tawara, I., Takemitsu, T., Saito, K., Wang, L., Ikarashi, Y., Wakasugi, H., Nakayama, T., Taniguchi, M., Kuribayashi, K., Old, L.J., Shiku, H.
  • Journal Title: P r o c. N a t l. A c a d. S c i. U S A 102 Pages: 9253-9257
  • Peer Reviewed
• [Journal Article] Differentiation of NK1 and NK2 cells. (2005)
  • Author(s): Kimura, Y.M., Nakayama, T.
  • Journal Title: C r i t. R e v. I m m. 25 Pages: 361-374
  • Peer Reviewed
• [Journal Article] Induction of regulatory properties in dendritic cells by Vα14 NKT cells. (2005)
  • Author(s): Kojo, S., Seino, K., Harada, M., Watarai, H., Wakao, H., Uchida, T., Nakayama, T., Taniguchi, M.
  • Journal Title: J. Immunol. 175 Pages: 3648-3655
  • Peer Reviewed
• [Journal Article] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. (2005)
  • Author(s): Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., Nakayama, T.
  • Journal Title: J. B i o l. C h e m. 280 Pages: 29409-29419
  • Peer Reviewed
• [Journal Article] Dendritic cell maturation by CD11c - T cells and Vα24+ natural killer T -cell activation byα-Galactosylceramide. (2005)
  • Author(s): Ishikawa, E., Motohashi, S., Ishikawa, A., Ito, T., Uchida, T., Kaneko, T., Tanaka, Y., Horiguchi, S., Okamoto, Y., Fujisawa, T., Tsuboi, K., Taniguchi, M., Matsumura, A., Nakayama, T.
  • Journal Title: I n t. J. C a n c e r 117 Pages: 265-273
  • Peer Reviewed
• [Journal Article] Adjuvant activity mediated by iNKT cells.
  • Author(s): Fujii, S., Motohashi, S., Shimizu, K., Nakayama, T., Yoshiga, Y., Taniguchi, M.
  • Journal Title: S e m i n. I m m u n o l. (in press)
  • Peer Reviewed
• [Presentation] CD4 T細胞の機能分化と維持のメカニズム (2009)
  • Author(s): 中山俊憲
  • Organizer: 第39回日本免疫学会総会・学術集会レビュ-ト-ク
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] ヒト免疫疾患におけるメモリ-T細胞の役割:新展開 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第37回日本臨床免疫学会総会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-11-13
• [Presentation] iNKT cell based immunotherapy for cancer. (2009)
  • Author(s): Nakayama, T.
  • Organizer: Japanese-German Cancer Workshop
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2009-09-18
• [Presentation] Development of new immunotherapy for cancer: iNKT cell-based immunotherapy. (2009)
  • Author(s): Nakayama, T.
  • Organizer: Thailand Research Expo 2009
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2009-08-29
• [Presentation] CD4陽性T細胞の機能分化:機能獲得と維持のメカニズム (2009)
  • Author(s): 中山俊憲
  • Organizer: 第21回日本比較免疫学会学術集会
  • Place of Presentation: 藤沢
  • Year and Date: 2009-08-04
• [Presentation] 次世代型"がん"治療免疫治療の最前線 (2009)
  • Author(s): 中山俊憲
  • Organizer: 日本試薬協会講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-01
• [Presentation] ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness. (2009)
  • Author(s): Nakayama, T.
  • Organizer: 96th Annual Meeting the American Association of Immunologists Immunology 2009
  • Place of Presentation: Seattle
  • Year and Date: 2009-05-09
• [Presentation] 免疫システム、その統御による免疫治療の開発研究 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第9回Cardiovascular Frontier Conference (CFC)
  • Place of Presentation: 東京
  • Year and Date: 2009-04-04
• [Presentation] Initiation and maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Combination therapy of In vitro expanded natural killer T cells and αGalactosyl Ceramide pulsed APCs in patients with recurrent head and neck carcinoma. (2008)
  • Author(s): Nakayama, T.
  • Organizer: The Second International Cell Therapy Conference Present a nd Future of Cell Therapy
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-20
• [Presentation] 細菌・アレルギー・癌と戦う免疫細胞を見る (2008)
  • Author(s): 中山俊憲
  • Organizer: 第17回日本バイオイメージング学会学術講演会公開講座
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-31
• [Presentation] A Phase I/II study of αGalCer-pulsed dendritic cells in patients with advanced or recurrent non-small cell lung cancer (2008)
  • Author(s): 中山俊憲
  • Organizer: 日本臨床免疫学会総会シンポジウム
  • Place of Presentation: 新宿
  • Year and Date: 2008-10-17
• [Presentation] メモリーTh1/Th2細胞の形成と維持機構 (2008)
  • Author(s): 中山俊憲
  • Organizer: 第44回日本移植学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-20
• [Presentation] 免疫システム<、その統御による免疫治療の開発研究 (2008)
  • Author(s): 中山俊憲
  • Organizer: 第84回千葉医学会学術大会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-05
• [Presentation] Regulation of memory Th2 cell survival and function by the Polycomb group and Trithorax group gene products. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Immunochemistry & Immunobiology, Magdalen College
  • Place of Presentation: Oxford, UK
  • Year and Date: 2008-08-20
• [Presentation] NKT細胞免疫系を利用した癌の免疫細胞治療 (2008)
  • Author(s): 中山俊憲
  • Organizer: 第4回北海道癌免疫制御研究会
  • Place of Presentation: 札幌
  • Year and Date: 2008-06-07
• [Presentation] Bmi1 regulates memory Th2 cell survival via repression of the Noxa gene. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Experimental Biology 2008, San Diego Convention Center
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-04-06
• [Presentation] Initiation and maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Allergy Symposium Program La Jolla Institute for Allergy and Immunology (LIAI)
  • Place of Presentation: USA
  • Year and Date: 2008-04-04
• [Presentation] Initiation and maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Karp Family Research Laboratories, One Blackfan Circle, 10th Floor Conference Room
  • Place of Presentation: Boston, USA
  • Year and Date: 2008-03-03
• [Presentation] Initiation an d maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: National Jewish Medical and Research Center, University of Colorado at Denver and Health Sciences Center
  • Place of Presentation: Denver, USA
  • Year and Date: 2008-02-22
• [Presentation] 免疫細胞療法 (2007)
  • Author(s): 中山俊憲
  • Organizer: トランスレ-ショナルリサ-チLesson & Lectureシリ-ズ
  • Place of Presentation: 東京
  • Year and Date: 2007-10-17
• [Presentation] Regulation of the generation and maintenance of memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-04
• [Presentation] NKT細胞免疫療法の開発研究と肺がんにおける治療 (2007)
  • Author(s): 中山俊憲
  • Organizer: 第23回東日本癌免疫療法研究会
  • Place of Presentation: 甲府
  • Year and Date: 2007-09-08
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: California Institute of Technology
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2007-05-22
• [Presentation] Schnurri -2 controls memory Th1 and Th2 cell numbers in vivo. (2007)
  • Author(s): Nakayama, T.
  • Organizer: Immunology 2007
  • Place of Presentation: Miami Beach, FL, USA
  • Year and Date: 2007-05-21
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: California Institute of Technology
  • Place of Presentation: Pasadena, CA, USA
  • Year and Date: 2007-05-17
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: NCI, NIH
  • Place of Presentation: Bethesda, MD, USA
  • Year and Date: 2007-04-30
• [Presentation] Crucial role of MLL for the maintenance of memory Th2 cell identity. (2007)
  • Author(s): Nakayama, T.
  • Organizer: Immunology Seminar Series, University of Chicago
  • Place of Presentation: USA
  • Year and Date: 2007-04-23
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nak ayama, T.
  • Organizer: Benaroya Research Institute
  • Place of Presentation: USA
  • Year and Date: 2007-03-12
• [Presentation] Schnurri -2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: La Jolla Institute for Allergy and Immunology
  • Place of Presentation: La Jolla, USA
  • Year and Date: 2007-03-08
• [Presentation] NKT細胞免疫系をタ-ゲットにしたがんの免疫細胞療法 (2006)
  • Author(s): 中山俊憲
  • Organizer: 癌領域におけるトランスレ-ションリサ-チセミナ-
  • Place of Presentation: 山口
  • Year and Date: 2006-11-22
• [Presentation] Visualization of lymphocyte migration in the asthmatic lung. (2006)
  • Author(s): Nakayama, T.
  • Organizer: The International Symposia for Bioimaging
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-30
• [Presentation] Chromatin remodeling of the Th2 cytokine gene loci. (2005)
  • Author(s): Nakayama, T.
  • Organizer: Cellular & Molecular Immunology FIMSA 2005
  • Place of Presentation: Hangzhou China
  • Year and Date: 20050418-20080422
• [Book] Memory Th1/Th2 cell generation controlled by schnurri-2. M e m o r y T - C e l l s (edited by Maurizio Zanetti) (2009)
  • Author(s): Nakayama, T., Kimura, Y.M.
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/meneki/homeb.htm
• [Remarks]
  • URL: http://www.isrt-gcoe-chiba.jp/