2009 Fiscal Year Final Research Report
Development of anti-tumor agents based on biological response modification.
| Project/Area Number |
17016013
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HASHIMOTO Yuichi The University of Tokyo, 分子細胞生物学研究所, 教授 (90164798)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hisayoshi 東京大学, 分子細胞生物学研究所, 助教 (80225531)
NOGUCHI Tomomi 東京大学, 分子細胞生物学研究所, 技術職員 (20401284)
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| Project Period (FY) |
2005 – 2009
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| Keywords | がん治療 / 構造展開 / 構造活性相関 / サリドマイド |
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| Research Abstract |
Various kinds of biologically active compounds were prepared based on biological response modification, so as to avoid possible side effects elicited specifically by cytotoxic anti-tumor agents. Nuclear receptor ligands and thalidomide (and/or its metabolite) were selected as major seeds compounds, and their structural development and activity expansion studies were performed.
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Research Products
(13 results)
