Treatment of advanced liver cancer targeting tumor and tumor-related markers

2009 Fiscal Year Final Research Report

• Project/Area Number: 17016016
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: MAEDA Shin The University of Tokyo, 医学部附属病院, 特任講師 (40415956)
• Co-Investigator(Kenkyū-buntansha): ENOMOTO Nobuyuki 山梨大学, 大学院・医学工学総合研究部, 教授 (20251530) ; SASAKI Shigeru 札幌医科大学, 医学部, 講師 (10305229) ; KANAI Fumihiko 東京大学, 医学部附属病院, 特任准教授 (70334399) ; TATEISHI Keisuke 東京大学, 医学部附属病院, 助手 (20396948) ; TANAKA Yasuo 東京大学, 医学部附属病院, 寄附講座教員 (40422290)
• Project Period (FY): 2005 – 2009
• Keywords: 癌 / 遺伝子 / ゲノム / 炎症

Research Abstract

This project has attempted to find out new biological markers relating to hepato-cellular carcinoma (HCC) and develop new treatment protocol against HCC. To analyze many clinical samples, some experimental systems including Genechip, Protein array, and Mass spectrometry were applied to the assay, and the data was comprehensively analyzed. As the achievements in this period, we found that 1) The tumor incidence rate is related to the serum concentration of IL-6 in women, 2) Platelet Factor 4(PF4), Angiogenin(ANG), TIMP-1, Serpin E1(PAI-1), VEGF are upregulated and Hip is decreased in HCC, 3) In the serum after the ablation of HCC, proapolipoprotein, α2-HS glycoprotein, apolipoprotein A-IV precursor, PRO1708/PRO2044 are decreased and leucine-rich α2-glycoprotein、α1-antitrypsin are increased, 4) High DCP can be a prognostic factor of PVTT . In addition, 5) We designed and performed the randomized control study about the effect of VitaminK treatment against HCC recurrence.

Research Products

• [Journal Article] Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy (2010)
  • Author(s): Mizui T, Yamashina S, Tanida I, Takei Y, Ueno T, Sakamoto N, Ikejima K, Kitamura T, Enomoto N, Sakai T, Kominami E, Watanabe S.
  • Journal Title: J Gastroenterol 45(in press) Pages: 195-203
  • Peer Reviewed
• [Journal Article] Ikappa B kinasebeta/ nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression (2009)
  • Author(s): Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M.
  • Journal Title: Hepatology 50 Pages: 1851-1860
  • Peer Reviewed
• [Journal Article] Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences. (2009)
  • Author(s): Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato N, Shiina S, Omata M.
  • Journal Title: Int J Cancer 125 Pages: 2264-2269
  • Peer Reviewed
• [Journal Article] Percutaneous radiofrequency ablation of hepatocellular carcinoma in 14 patients undergoing regular hemodialysis for end-stage renal disease. (2009)
  • Author(s): Kondo Y, Yoshida H, Tomizawa Y, Tateishi R, Shiina S, Tagawa K, Omata M.
  • Journal Title: Am J Roentgenol 193 Pages: 964-969
  • Peer Reviewed
• [Journal Article] Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography. (2009)
  • Author(s): Masuzaki R, Tateishi R, Yoshida H, Goto E, Sato T, Ohki T, Imamura J, Goto T, Kanai F, Kato N, Ikeda H, Shiina S, Kawabe T, Omata M.
  • Journal Title: Hepatology 49 Pages: 1954-1961
  • Peer Reviewed
• [Journal Article] Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH. (2009)
  • Author(s): Ohki T, Tateishi R, Shiina S, Goto E, Sato T, Nakagawa H, Masuzaki R, Goto T, Hamamura K, Kanai F, Yoshida H, Kawabe T, Omata M.
  • Journal Title: Gut 58 Pages: 839-844
  • Peer Reviewed
• [Journal Article] DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer. (2009)
  • Author(s): Matsui A, Yamaguchi T, Maekawa S, Miyazaki C, Takano S, Uetake T, Inoue T, Otaka M, Otsuka H, Sato T, Yamashita A, Takahashi Y, Enomoto N.
  • Journal Title: Cancer Sci 100 Pages: 1923-1930
  • Peer Reviewed
• [Journal Article] Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis C. (2009)
  • Author(s): Maekawa S, Enomoto N.
  • Journal Title: J Gastroenterol 44 Pages: 1009-1015
  • Peer Reviewed
• [Journal Article] Potential relevance of cytoplasmic viral sensors and related regulators involving innate immunity in antiviral response. (2008)
  • Author(s): Asahina Y, Izumi N, Hirayama I, Tanaka T, Sato M, Yasui Y, Komatsu N, Umeda N, Hosokawa T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Kurosaki M, Enomoto N, Tasaka M, Sakamoto N, Miyake S.
  • Journal Title: Gastroenterology 134 Pages: 1396-1405
  • Peer Reviewed
• [Journal Article] Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients (2008)
  • Author(s): Li Y, Tanaka Y, Tada M, Hua R, Seto M, Asaoka Y, Ohta M, Kanai F, Yoshida H, Kawabe T, Sano T, Motojima T, Yokosuka O, Omata M.
  • Journal Title: APMIS 116 Pages: 931-933
  • Peer Reviewed
• [Journal Article] Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting C-Jun N-terminal kinase activation. (2008)
  • Author(s): Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M.
  • Journal Title: Gastroenterology 135 Pages: 1311-1321
  • Peer Reviewed
• [Journal Article] Rapid detection of the hepatitis B virus YMDD mutant using TaqMan-minor groove binder probes (2008)
  • Author(s): Hua R, Tanaka Y, Fukai K, Tada M, Seto M, Asaoka Y, Ohta M, Goto T, Kanai F, Kato N, Yoshida H, Kawabe T, Yokosuka O, Omata M.
  • Journal Title: Clin Chim Acta 395 Pages: 151-154
  • Peer Reviewed
• [Journal Article] Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma (2008)
  • Author(s): Tada M, Kanai F, Tanaka Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Muroyama R, Fukai K, Imazeki F, Kawabe T, Yokosuka O, Omata M.
  • Journal Title: Clin Cancer Res 14 Pages: 3768-3776
  • Peer Reviewed
• [Journal Article] Association of interferon regulatory factor -7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients (2008)
  • Author(s): Sermasathanasawadi R, Kato N, Muroyama R, Dharel N, Shao RX, Chang JH, Li CZ, Kawabe T, Omata M.
  • Journal Title: Liver Int 28 Pages: 798-806
  • Peer Reviewed
• [Journal Article] Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus (2008)
  • Author(s): Dharel N, Kato N, Muroyama R, Taniguchi H, Otsuka M, Wang Y, Jazag A, Shao RX, Chang JH, Adler MK, Kawabe T, Omata M.
  • Journal Title: Hepatology 47 Pages: 1136-1149
  • Peer Reviewed
• [Journal Article] The presence of steatosis and elevation of alanine aminotransferase levels are associated with fibrosis progression in chronic hepatitis C with non-response to interferon therapy (2008)
  • Author(s): Kurosaki M, Matsunaga K, Hirayama I, Tanaka T, Sato M, Komatsu N, Umeda N, Hosokawa T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Asahina Y, Miyake S, Enomoto N, Izumi N.
  • Journal Title: J Hepatol 48 Pages: 736-742
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma (2008)
  • Author(s): Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y.
  • Journal Title: J Gastroenterol 43 Pages: 378-389
  • Peer Reviewed
• [Journal Article] Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity (2008)
  • Author(s): Sekine-Osajima Y, Sakamoto N, Nakagawa N, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Wakita T, Enomoto N, Watanabe M.
  • Journal Title: Virology 37 Pages: 171-185
  • Peer Reviewed
• [Journal Article] Targeting lipid metabolism in the treatment of hepatitis C virus infection (2008)
  • Author(s): Amemiya F, Maekawa S, Itakura Y, Kanayama A, Matsui S, Takano S, Yamaguchi T, Itakura T, Kitamura T, Inoue T, Sakamoto M, Yamauchi K, Okada S, Yamashita S, Sakamoto N, Itoh M, Enomoto N.
  • Journal Title: J Infect Dis 197 Pages: 361-370
  • Peer Reviewed
• [Journal Article] Assessing liver tumor stiffness by transient elastography (2007)
  • Author(s): Masuzaki R, Tateishi R, Yoshida H, Sato T, Ohki T, Goto T, Yoshida H, Sato S, Sugioka Y, Ikeda H, Shiina S, Kawabe T, Omata M.
  • Journal Title: Hepatol Int 1 Pages: 394-397
  • Peer Reviewed
• [Journal Article] Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: Retrospective study (2007)
  • Author(s): Yamashita H, Nakagawa K, Shiraishi K, Tago M, Igaki H, Nakamura N, Sasano N, Siina S, Omata M, Ohtomo K.
  • Journal Title: J Gastroen Hepatol 22 Pages: 523-527
  • Peer Reviewed
• [Journal Article] Local ablation therapy for hepatocellular carcinoma. From ethanol injection to radiofrequency ablation (2007)
  • Author(s): Shiina S, Tateishi R, Yoshida H, Kanai F, Omata M.
  • Journal Title: Saudi Med J 28 Pages: 831-837
  • Peer Reviewed
• [Journal Article] Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response (2007)
  • Author(s): Tasaka M, Sakamoto N, Itakura Y, Nakagawa M, Itusi Y, Sekine-Osajima Y, Nishimura-Sakurai Y, Chen CH, Yoneyama M, Fujita T, Wakita T, Maekawa S, Enomoto N, Watanabe M
  • Journal Title: J Gen Virol 88 Pages: 3323-3333
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer (2007)
  • Author(s): Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y.
  • Journal Title: Oncogene 26 Pages: 4699-4713
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors (2007)
  • Author(s): Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y.
  • Journal Title: Carcinogenesis 28 Pages: 2459-2466
  • Peer Reviewed
• [Journal Article] Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients (2006)
  • Author(s): Tanaka Y, Kanai F, Tada M, Asaoka Y, Guleng B, Jazag A, Ohta M, Ikenoue T, Tateishi K, Obi S, Kawabe T, Yokosuka O, Omata M.
  • Journal Title: Oncogene 25 Pages: 2950-2952
  • Peer Reviewed
• [Journal Article] Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma (2006)
  • Author(s): Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, Shao RX, Dharel N, Tanaka Y, Ohta M, Tateishi R, Shiina S, Tatsukawa M, Fukai K, Imazeki F, Yokosuka O, Shiratori Y, Omata M.
  • Journal Title: J Hepatol 45 Pages: 805-812
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation for hepatocellular carcinoma in so-called high-risk locations (2006)
  • Author(s): Teratani T, Yoshida H, Shiina S, Obi S, Sato S, Tateishi R, Mine N, Kondo Y, Kawabe T, Omata M.
  • Journal Title: Hepatology 43 Pages: 1101-1108
  • Peer Reviewed
• [Journal Article] MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C (2006)
  • Author(s): Dharel N, Kato N, Muroyama R, Moriyama M, Shao RX, Kawabe T, Omata M.
  • Journal Title: Clin Cancer Res 12 Pages: 4867-4871
  • Peer Reviewed
• [Journal Article] EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus (2006)
  • Author(s): Hanawa M, Suzuki S, Dobashi Y, Yamane T, Kono K, Enomoto N, Ooi A.
  • Journal Title: Int J Cancer 118 Pages: 1173-1180
  • Peer Reviewed
• [Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor-3 (2006)
  • Author(s): Yamashiro T, Sakamoto N, Kurosaki M, Kanazawa N, Tanabe Y, Nakagawa M, Chen CH, Itsui Y, Koyama T, Takeda Y, Maekawa S, Enomoto N, Sakugawa H, Watanabe M.
  • Journal Title: J Gastroenterol 41 Pages: 750-757
  • Peer Reviewed
• [Journal Article] The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1 (2006)
  • Author(s): Tanaka Y, Kanai F, Ichimura T, Tateishi K, Asaoka Y, Guleng B, Jazag A, Ohta M, Imamura J, Ikenoue T, Ijichi H, Kawabe T, Isobe T, Omata M.
  • Journal Title: Oncogene 25 Pages: 633-642
  • Peer Reviewed
• [Journal Article] TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors (2006)
  • Author(s): Tateishi K, Ohta M, Guleng B, Kanai F, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Imamura T, Ijichi H, Ikenoue T, Kawakami T, Fukushima Y, Washida M, Sata M, Miyagishi M, Taira K, Yoshida H, Kawabe T, Omata M.
  • Journal Title: Int J Cancer 118 Pages: 2237-2246
  • Peer Reviewed
• [Journal Article] Acyclic retinoid inhibits human hepatoma cell growth by suppressing fibroblast growth factor-mediated signaling pathways (2005)
  • Author(s): Shao R-X, Otsuka M, Kato N, Taniguchi H, Hoshida Y, Moriyama M, Kawabe T, Omata M.
  • Journal Title: Gastroenterology 128 Pages: 86-95
  • Peer Reviewed
• [Journal Article] Proteomic analysis of sera from hepatocellular carcinoma patients after radiofrequency ablation treatment (2005)
  • Author(s): Kawakami T, Hoshida Y, Kanai F, Tanaka Y, Tateishi K, Ikenoue T, Obi S, Sato S, Teratani T, Shiina S, Kawabe T, Suzuki T, Hatano N, Taniguchi H, Omata M.
  • Journal Title: Proteomics 5 Pages: 4287-4295
  • Peer Reviewed
• [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins (2005)
  • Author(s): Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsu Y, Takeda Y, Chen C-H, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M.
  • Journal Title: Gastroenterology 129 Pages: 1031-1041
  • Peer Reviewed
• [Journal Article] Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy (2005)
  • Author(s): Hamano K, Sakamoto N, Enomoto N, Izumi N, Asahina Y, Kurosaki M, Ueda E, Tanabe Y, Maekawa S, Itakura J, Watanabe H, Kakinuma S, Watanabe M.
  • Journal Title: J Gastroenterol Hepatol 20 Pages: 1401-1409
  • Peer Reviewed
• [Journal Article] Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes (2005)
  • Author(s): Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M, Murphy DG, Okamoto H, Pawlotsky JM, Penin F, Sablon E, Shin-I T, Stuyver LJ, Thiel HJ, Viazov S, Weiner AJ, Widell A.
  • Journal Title: Hepatology 42 Pages: 962-973
  • Peer Reviewed
• [Journal Article] Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C (2005)
  • Author(s): Asahina, Izumi N, Enomoto N, Uchihara M, Kurosaki M, Onuki Y, Nishimura Y, Ueda K, Tsuchiya K, Nakanishi H, Kitamura T, Miyake S.
  • Journal Title: J Hepatol 43 Pages: 623-629
  • Peer Reviewed
• [Journal Article] Genetic changes in the interferon sensitivity-determining region of hepatitis C virus (HCV) during the natural course of infection: an implication for the gene function in the role of chronic infection (2005)
  • Author(s): Maekawa S, Enomoto N.
  • Journal Title: J Gastroenterol 40 Pages: 113-115
  • Peer Reviewed
• [Presentation] Not HBX but fusion HBX translated from HBV integrant is associated with the development and progression of hepatocellular carcinoma (2009)
  • Author(s): Muroyama R, Kowatari N, Hu Z, Chang JH, Otsuka M, Omata M, Kato N.
  • Organizer: 60th AASLD
  • Place of Presentation: Boston
  • Year and Date: 2009-11-03
• [Presentation] Respective quantification of hepatitis C virus genotype 1B codon 70 wild and mutant types and their response and pegifin/RBV treatment (2009)
  • Author(s): Hu Z, Muroyama R, Goto T, Kowatari N, Chang JH, Omata M, Kato N.
  • Organizer: 60th AASLD
  • Place of Presentation: Boston
  • Year and Date: 2009-11-01
• [Presentation] Taqmanプローブを用いたLOH解析による再発肝癌のクロナリティーに関する検討 (2009)
  • Author(s): 浅岡良成、田中康雄、中川勇人、増崎亮太、多田素久、建石良介、伊地知秀明、池上恒雄、前田愼、吉田晴彦、小俣政男
  • Organizer: JDDW 2009
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] c型肝炎における発癌を規定するウイルス因子と宿主因子 (2009)
  • Author(s): 加藤直也、室山良介、小俣政男
  • Organizer: JDDW 2009
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] 肝炎の進行と治療感受性を規定するウイルス領域の包括的検討 (2009)
  • Author(s): 前川伸哉, 坂本穣, 榎本信幸
  • Organizer: JDDW2009
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] b型肝炎ウイルスによる新たな発癌機構 (2009)
  • Author(s): 室山良介、加藤直也、小俣政男
  • Organizer: JDDW2009
  • Place of Presentation: 京都
  • Year and Date: 2009-10-14
• [Presentation] C型肝炎ウイルスコア遺伝子の特徴的変異が肝細胞癌発生に関連する可能性 (2009)
  • Author(s): 胡中傑、加藤直也、室山良介、常金海、小俣政男, 他
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] hcvゲノム解析による肝発癌に関連するc型肝炎ウイルス遺伝子領域の検索 (2009)
  • Author(s): 三浦美香, 前川伸哉, 榎本信幸
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] HCVゲノム多型は抗ウイルス治療効果を規定する (2009)
  • Author(s): 前川伸哉, 坂本穣, 榎本信幸
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Presentation] Diagnosis of intrahepatic metastasis and multicentric carcinogenesis in the patients with hepatocellular carcinoma by Loss of heterozygosity analysis using taqman SNP genotyping assays (2009)
  • Author(s): Asaoka Y, Tanaka Y, Nakagawa H, Masuzaki R, Tada M, Tateishi R, Ijichi H, Ikenoue T, Maeda S, Yoshida H, Kawabe T, Omata M.
  • Organizer: DDW
  • Place of Presentation: Chicago
  • Year and Date: 2009-06-01
• [Presentation] Serum IL-6 levels and the risk of hepatocarcinogenesis in chronic hepatitis C patients (2009)
  • Author(s): Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato N, Shiina S, Omata M.
  • Organizer: DDW 2009
  • Place of Presentation: Chicago
  • Year and Date: 2009-06-01
• [Presentation] 早期肝細胞癌診断におけるEOB-MRI検査の有用性 (2009)
  • Author(s): 雨宮史武, 北村敬利, 榎本信幸.
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] Fusion HBx from HBV integrant in human hepatoma cell line is implicated in the development and progression of hepatocellular carcinoma (2008)
  • Author(s): Muroyama R, Kato N, Otsuka M, Chang JH, Omata M.
  • Organizer: 59th AASLD
  • Place of Presentation: San Francisco
  • Year and Date: 2008-11-02
• [Presentation] アセトアミノフェン肝障害におけるApotosis signal-regulating kinase1(ASK1)-JNK (2008)
  • Author(s): 中川勇人、前田愼、小俣政男
  • Organizer: 経路の関与JDDW
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] Whole HCV genome sequencingによる治療感受性規定領域の検索 (2008)
  • Author(s): 前川伸哉, 坂本穣, 榎本信幸
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2008-10-02
• [Presentation] 遺伝子変異からみた1b型のC型慢性肝炎に対するインターフェロンのテーラーメード治療の可能性 (2008)
  • Author(s): 坂本穣, 井上泰輔, 榎本信幸
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2008-10-02
• [Presentation] 組込みB型肝炎ウイルス由来のHBxによる新しい肝発癌メカニズムの提唱とその検証 (2008)
  • Author(s): 室山良介、加藤直也、小俣政男
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2008-10-01
• [Presentation] ウイルス変異からみたC型慢性肝炎の治療法 (2008)
  • Author(s): 坂本穣, 前川伸哉, 榎本信幸
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2008-10-01
• [Presentation] 肝臓癌及び消化器癌の日本人患者におけるAKT1のpleckstrinホモロジードメイン変異の欠落 (2008)
  • Author(s): Li Y、田中康雄、多田素久、華瑞、瀬戸元子、浅岡良成、大田幹、金井文彦、吉田晴彦、川邊隆夫、横須賀収、小俣政男
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛
  • Year and Date: 2008-06-06
• [Presentation] HCV全ゲノム検索によるペグインターフェロン・リバビリン併用療法における治療感受性規定領域の決定 (2008)
  • Author(s): 前川伸哉, 金山明日香, 宮崎千賀子, 雨宮史武, 松井啓, 北村敬利, 井上泰輔, 坂本穣, 岡田俊一, 榎本信幸
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛
  • Year and Date: 2008-06-06
• [Presentation] Deletion of apoptosis signal-regulating kinase 1 (ASK1) attenuates acetaminophen-induced liver injury by inhibiting prolonged JNK activation (2008)
  • Author(s): Nakagawa H, Maeda S, Sakamoto K, Hayakawa Y, Ogura K, Omata M.
  • Organizer: DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-20
• [Presentation] HCV遺伝子構造による自然免疫RIG-I経路阻害活性の検討 (2008)
  • Author(s): 前川伸哉, 榎本信幸
  • Organizer: 第94回日本消化器病学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-08
• [Presentation] 進行肝細胞癌に対する新規抗体治療 (2008)
  • Author(s): 佐々木茂、石田禎夫、五十嵐麻衣、安井寛、高木秀安、阿久津典之、大橋広和、大関令奈、山本博幸、篠村恭久、今井浩三
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-08
• [Presentation] A critical appraisal of surgical resection and local ablative therapy for HCC; debate between experts (2008)
  • Author(s): Omata M.
  • Organizer: 18th APASL
  • Place of Presentation: Seoul
  • Year and Date: 2008-03-24
• [Presentation] Liver fibrosis and hepatocellular carcinoma; diagnosis and prevention (2008)
  • Author(s): Omata M.
  • Organizer: 3rd APASL-STC Cairo
  • Place of Presentation: Egypt
  • Year and Date: 2008-01-30
• [Presentation] 高密度オリゴヌクレオチドアレイから抽出した遺伝子を用いた肝癌臨床検体のコピー数解析 (2007)
  • Author(s): 田中康雄、金井文彦、多田素久、建石良介、浅岡良成、瀬戸元子、大田幹、立石敬介、椎名秀一朗、吉田晴彦、川邊隆夫、横須賀収、小俣政男
  • Organizer: JDDW
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-19
• [Presentation] 進行肝細胞がんに対する抗体治療 (2007)
  • Author(s): 佐々木茂、石田禎夫、篠村恭久、今井浩三
  • Organizer: 第35回日本臨床免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-19
• [Presentation] ISDRからみたC型慢性肝炎のPEG-IFN/Ribavirin療法の解析 (2007)
  • Author(s): 坂本穣, 井上泰輔, 榎本信幸
  • Organizer: DDW-Japan
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-18
• [Presentation] 肝細胞を特異的に造影する造影剤Gd-EOB-DTPA(SH L 569 B)を用いたMR検査の可能性 (2007)
  • Author(s): 北村敬利, 市川智章, 榎本信幸
  • Organizer: DDW-Japan
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-18
• [Presentation] Therapeutic options of HCC (2007)
  • Author(s): Omata M.
  • Organizer: The 1st China-Indonesia Joint International Symposium on Hepatobiliary Medicine and Surgery Discovery Kartika Plaza
  • Place of Presentation: Bali
  • Year and Date: 2007-08-24
• [Presentation] 肝細胞癌(HCC)に対するラジオ波焼灼術(RFA)の成績 (2007)
  • Author(s): 椎名秀一朗、建石良介、小俣政男
  • Organizer: 第43回日本肝癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-21
• [Presentation] 肝発癌によるHedgehog-interacting protein (HHIP)の関与 (2007)
  • Author(s): 多田素久、金井文彦、田中康雄、立石敬介、大田幹、浅岡良成、瀬戸元子、今関文夫、川邊隆夫、横須賀収、小俣政男
  • Organizer: 第43回日本肝癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-01
• [Presentation] ISDRからみたC型慢性肝炎に対するPEG-IFN+Ribavirin療法の治療効果と72週治療の試み (2007)
  • Author(s): 坂本穣, 井上泰輔, 雨宮史武, 北村敬利, 前川伸哉, 岡田俊一, 榎本信幸
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-01
• [Presentation] C型肝炎ウイルス遺伝子構造による自然免疫回避の検討 (2007)
  • Author(s): 前川伸哉, 板倉嘉恵, 榎本信幸
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-31
• [Presentation] Stage IV-A, B肝細胞癌の予後は改善できる (2007)
  • Author(s): 小尾俊太郎、今村潤、小俣政男
  • Organizer: 第93回日本消化器病学会総会
  • Place of Presentation: 青森
  • Year and Date: 2007-04-20
• [Presentation] ISDRからみたPEG-IFN+Ribavirin併用療法の初期抗ウイルス効果(EVR)とSVR (2006)
  • Author(s): 坂本穣, 井上泰輔, 榎本信幸
  • Organizer: 第36回日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2006-12-08
• [Presentation] 非B非C型肝細胞癌症例の臨床的特徴の検討. DDW-Japan2005 (2005)
  • Author(s): 岡田俊一, 榎本信幸
  • Organizer: 第9回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 20051000
• [Presentation] C型肝炎ウイルス増殖を規定するHCV遺伝子領域の検索 (2005)
  • Author(s): 雨宮史武, 前川伸哉, 坂本直哉, 坂本穣, 斉藤晴久, 岡田俊一, 板倉潤, 小橋高宏, 田邊陽子, 中川美奈, 井津井康浩, 小山知行, 武田嘉恵, 田坂めぐみ, 関根裕子, 柿沼晴, 渡辺守, 榎本信幸
  • Organizer: 第41回日本肝臓学会総
  • Place of Presentation: 大阪
  • Year and Date: 20050600