2009 Fiscal Year Final Research Report
Polymeric micelle nanocarrier for drug and gene delivery
| Project/Area Number |
17016017
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATAOKA Kazunori The University of Tokyo, 大学院・工学系研究科, 教授 (00130245)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Yuichi 東京大学, 大学院・工学系研究科, 准教授 (00322678)
NISHIYAMA Nobuhiro 東京大学, 大学院・医学系研究科, 准教授 (10372385)
OSADA Kensuke 東京大学, 大学院・工学系研究科, 特任講師 (10396947)
MIYATA Kanjiro 東京大学, 大学院・医学系研究科, 助教 (50436523)
KISHIMURA Akihiro 東京大学, 大学院・工学系研究科, 助教 (70422326)
ISHII Takehiko 東京大学, 大学院・工学系研究科, 特任助教 (80415075)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ドラッグデリバリー / ナノキャリア / 高分子ミセル / がん化学療法 / 遺伝子治療 / siRNA / ナノテクノロジー |
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| Research Abstract |
To realize the targeting therapy against intractable tumors, we developed functional polymeric micelles integrated with the sensitivity to intracellular low pH conditions and the ability to bind the specific cells for the delivery of antitumor agents, and demonstrated their effectiveness in the in vivo study using tumor-bearing mice. Also, to establish the molecular cancer therapy based on gene delivery, we developed a non-viral gene vector based on polymeric micelles stabilized through the cross-linking cleavable under the intracellular reductive conditions, and succeeded in their application to antiangiogenic cancer therapy.
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