2009 Fiscal Year Final Research Report
Development of effective hematopoietic stem cell transplantation/cellular immunotherapy for adult T-cell leukemia
| Project/Area Number |
17016034
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
KADOWAKI Norimitsu Kyoto University, 医学研究科, 講師 (60324620)
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| Co-Investigator(Kenkyū-buntansha) |
HORI Toshiyuki 京都大学, 医学研究科, 講師 (70243102)
ISHIKAWA Takayuki 京都大学, 医学研究科, 講師 (10303835)
ICHINOHE Tatsuo 京都大学, 医学研究科, 助教 (80314219)
HISHIZAWA Masakatsu 京都大学, 医学研究科, 助教 (90444455)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ATL / 細胞・免疫療法 / 同種造血幹細胞移植 / 腫瘍関連抗原 / 樹状細胞 / NK細胞 / T細胞 |
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| Research Abstract |
Adult T-cell leukemia (ATL) caused by a retrovirus HTLV-I has long been intractable. We aimed to develop novel therapies that exploit allogeneic and autologous immune responses to ATL cells in this study. First we clarified prognostic factors in allogeneic stem cell transplantation for ATL by a nationwide retrospective study. Furthermore, we identified several novel ATL-associated antigens that are promising as targets for immunotherapy. We performed three clinical trials of DC-based immunotherapy for acute myeloid leukemia. Through these efforts, we established the basis to develop novel cellular immunotherapies for ATL.
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