2009 Fiscal Year Final Research Report
Analysis of molecular mechanisms of leukemia
| Project/Area Number |
17016042
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
KANAKURA Yuzuru Osaka University, 医学系研究科, 教授 (20177489)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 白血病 / 悪性リンパ腫 / チロシンキナーゼ / アポトーシス / 遺伝子変異 / シグナル伝達 / 造血幹細胞 |
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| Research Abstract |
We have tried to identify signaling or anti-apoptotic molecules, which have potential for novel therapeutic targets for leukemic treatment. We analyzed the function and molecular mechanisms in hematopoietic cell growth and leukemogenesis of Anamorsin, activated c-kit and Flt3, FIP1L1-PDGFR, and RUNX1 mutations. As a result, we found that these molecules might be candidates for novel molecular targets. In addition, we also identified several molecules whose mRNA expression is observed in leukemic stem cells, but not in normal hematopoietic stem cells.
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Research Products
(40 results)
