2009 Fiscal Year Final Research Report
Molecular targeting agents that suppress invasion and metastasis of cancer cells
| Project/Area Number |
17016058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
AKIYAMA Shinichi Kagoshima University, 大学院・医歯学総合研究科, 教授 (60117413)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Tatsuhiko 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (40219100)
YAMAMOTO Masatatsu 鹿児島大学, 大学院・医歯学総合研究科, 助教 (40404537)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Keywords | thymidine phosphorylase / 2-deoxy-D-ribose / IL-8 / ROS / NFκB / TSP-1 / 5-FU |
|---|
| Research Abstract |
Thymidine phosphorylase is an enzyme that has an angiogenic activity. 2-Deoxy-D-ribose, one of the degradation products of thymidine produced by TP also has an angiogenic activity. As well as the inhibitor of TP, 2-deoxy-L-ribose, an stereoisomer of 2-deoxy-D-ribose, suppressed the growth, invasion and metastasis of the TP-expressing tumors. ROS was produced by TP and 2-deoxy-D-ribose, and the ROS activated NFκB. The activated NFκB enhanced the expression of IL-8 and MMPs that are involved in angiogenesis.
|
Research Products
(35 results)
