2009 Fiscal Year Final Research Report
Immunotherapy using humanized monoclonal antibody
| Project/Area Number |
17016060
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
IMAI Kohzoh Sapporo Medical University, 学長 (60117603)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Tadao 札幌医科大学, 医学部, 准教授 (20305220)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ヒト抗体 / 免疫療法 / モノクローナル抗体 |
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| Research Abstract |
We have been developed the new monoclonal antibody against FGFR-1, which express on human hepatocellular carcinoma and induced by IFN. When we administrate this antibody and IFN simultaneously, strong anti-cancer effect was observed in vitro and in vivo. Furthermore, we have been developed other monoclonal antibodies aimed at therapy for gastric cancer. These are the humanized bispecific monoclonal antibody targeted tumor antigen×CD3 and the humanized trifunctional bispecific antibody which have the Fc region.
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Research Products
(19 results)
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[Journal Article] IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
Author(s)
Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JP, Shinomura Y, Tokino T, Toyota M
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Journal Title
Carcinogenesis Vol.31
Pages: 342-349
Peer Reviewed
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[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
Author(s)
Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
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Journal Title
Carcinogenesis Vol.29
Pages: 1312-1318
Peer Reviewed
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[Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007
Author(s)
Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
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Journal Title
Oncogene Vol.26
Pages: 4699-4713
Peer Reviewed
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[Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006
Author(s)
Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
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Journal Title
Cancer Res Vol.66
Pages: 4574-4583
Peer Reviewed
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