2009 Fiscal Year Final Research Report
Molecular mechanism and molecular targeting therapy in transIocation-related leukemia.
| Project/Area Number |
17016068
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
MITANI Kinuko Dokkyo Medical University, 医学部, 教授 (50251244)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Ko 獨協医科大学, 医学部, 講師 (60282638)
MAKI Kazuhiro 獨協医科大学, 医学部, 講師 (50337391)
TETSUYA Yamagata 獨協医科大学, 医学部, 准教授 (30424047)
MARIKO Eguchi 獨協医科大学, 医学部, 講師 (40420781)
MINENORI Eguchi 獨協医科大学, 医学部, 講師 (50420782)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 白血病 / 染色体転座 / 転写因子 / RUNX1, RUNX1 / EVI1 / ノックインマウス / ヒストン脱アセチル化酵素阻害剤 / TEL |
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| Research Abstract |
Generation of chimeric transcription factor is one of major molecular mechanisms in leukemogenesis. In this study, We analyzed functions of a RUNX1 chimera, RUNX1/EVI1, with molecular and gene engineering approaches. Considering that RUNX1 chimera causes leukemia through recruiting histone deacetylase via co-repressor, We also evaluated effects of hlstone deacetylase inhlbitors on leukemic growth induced by RUNX1 chimera.
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