2009 Fiscal Year Final Research Report
Development of immunotherapy based on the identification of tumor antigens
| Project/Area Number |
17016070
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Keio University |
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Principal Investigator |
KAWAKAMI Yutaka Keio University, 医学部, 教授 (50161287)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Tomonobu 慶應義塾大学, 医学部, 助教 (20199334)
SAKURAI Toshiharu 慶應義塾大学, 医学部, 助教 (20101933)
KUDO Chie 慶應義塾大学, 医学部, 講師 (90424126)
TSUKAMOTO Nobuo 慶應義塾大学, 医学部, 助教 (20407117)
UEDA Ryo 慶應義塾大学, 医学部, 助教 (30317143)
MATSUZAKI Yuriko 慶應義塾大学, 医学部, 助教 (40255435)
TSUKAMOTO Makoto 慶應義塾大学, 医学部, 助教 (50365441)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 免疫療法 / 腫瘍抗原 / がん幹細胞 / 上皮間葉転換 / 悪性黒色腫 |
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| Research Abstract |
Cancer immunotherapy has not been established as a standard cancer therapy. To improve current immunotherapy, in this project we have identified new human tumor antigens, revealed cancer immune responses particularly cancer induced immunosuppression, and evaluated immunological characteristics of cancer stem cells and epithelial-mesenchymal transitioned cancer cells. Newly identified tumor antigens and immune modulation methods may lead to development of new diagnostic and therapeutic methods for cancer.
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[Journal Article] A novel cancer testis antigen frequently expressed in pancreatic, lung and endometrial cancers.2006
Author(s)
Okada T, Akada M, Fujita T, Iwata T, Goto Y, Kido K, Okada T, Matsuzaki Y, Kobayashi K, Matsuno S, Sunamura M, Kawakami Y
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Journal Title
Clin Cancer Res. 12(1)
Pages: 191-197
Peer Reviewed
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[Journal Article] A new melanoma antigen FABP7 involved in proliferation and invasion is a potential target for immunotherapy and molecular target therapy.2006
Author(s)
Goto Y, Matsuzaki Y, Kurihara S, Shimizu A, Okada T, Yamamoto K, Murata H, Takata M, Aburatani H, Hoon D, Saida T, Kawakami Y
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Journal Title
Cancer Res. 66(8)
Pages: 4443-4449
Peer Reviewed
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[Journal Article] Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin Cell Wall Skeleton Stimulation.2006
Author(s)
Udagawa M, Kudo-Saito C, Hasegawa G, Yano K, Yamamoto A, Sumimoto H, Yaguchi M, Toda M, Azuma I, Iwai T, Kawakami Y
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Journal Title
Clin Cancer Res. 12(24)
Pages: 7465-7475
Peer Reviewed
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[Journal Article] Frequent immune responses to a cancer/testis antigen, CAGE, in patients with microsatellite instability positive endometrial cancer.2005
Author(s)
Iwata T, Fujita T, Hirao N, Matsuzaki Y, Okada T, Mochimaru H, Susumu N, Matsumoto E, Sugano K, Yamashita N, Nozawa S, Kawakami Y
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Journal Title
Clin Cancer Res. 11(10)
Pages: 3949-3957
Peer Reviewed
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[Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis.2005
Author(s)
Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y
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Journal Title
Int J Cancer 116(6)
Pages: 925-933
Peer Reviewed
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[Book] Gene Therapy(Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods)2009
Author(s)
Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Hasegawa G, Ishida A, Kitagawa Y, Tanabe M, Saito M, Izumi Y, Kawamura M, Yaguchi T, Ueda Y, Hayashi E, Wang Q, Tsukamoto N, Matsuzaki Y, Sumimoto H,Takeuchi H, Tanikawa A, Handa M, Amagai M, Kobayashi K, Ikeda Y, Azuma I, Kitajima M
Total Pages
240-248
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