2009 Fiscal Year Final Research Report
A search and its mechanism elucidation of a new molecular target for radiosensitization
| Project/Area Number |
17016073
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MITSUHASHI Norio Tokyo Women's Medical University, 医学部, 教授 (20008585)
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| Co-Investigator(Kenkyū-buntansha) |
AKIMOTO Tetsuo 東京女子医科大学, 医学部, 准教授 (10261851)
MAEBAYASHI Katsuya 東京女子医科大学, 医学部, 講師 (60332350)
IZUMI Sachiko 東京女子医科大学, 医学部, 助教 (50292602)
ISHIKAWA Hitoshi 群馬大学, 医学部, 講師 (70344918)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Hitoshi 群馬大学, 医学部, 講師 (70344918)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 放射線感受性 / 分子標的 / シグナル伝達 / 放射線増感 / 上皮細胞増殖因子受容体 / 細胞接着因子 / 子宮頸癌 / 放射線治療 |
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| Research Abstract |
Identification of the candidate gene and molecule constituting radiosensitivity and investigation of radiosensitization strategies which targeted them were performed. Consequently, it became evident that it can become a candidate moleculefor radiosensitization since molecules, such as HER family, Hsp90, H2AX, and CoX-2, are closely connected with radiosensitivity, and that characteristic changes in gene expression characteristic were observed according to the treatment modalities for cervical cancer patients.
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[Journal Article] Enhancement of radiosensitivity by dual inhibition of the HER family with ZD1839 ("Iressa") and trastuzumab ("Herceptin").2006
Author(s)
Fukutome, M., Maebayashi, K., Nasu, S., Seki, K., Mitsuhashi, N., 他3名, 5番目
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Journal Title
Int. J. Radiat. Oncol. Biol. Phys. 66(2)
Pages: 528-536
Peer Reviewed
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[Presentation] 子宮頸癌放射線治療におけるCOX-2発現と放射線感受性および局所治療効果との関連.2006
Author(s)
石川仁, 大野達也, 若月優, 岩川眞由美, 太田敏江, 今井高志, 三橋紀夫, 野田真永, 加藤真吾, 中野隆史, 辻井博彦
Organizer
第65回日本癌学会学術総会
Place of Presentation
横浜
Year and Date
2006-09-28
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