2009 Fiscal Year Final Research Report
Oncogenic signaling and screening of anticancer leads
| Project/Area Number |
17016085
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Iwate Medical University (2007, 2009)
Hirosaki Gakuin University (2008)
National Institute of Infectious Diseases (2005-2006) |
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Principal Investigator |
UEHARA Yoshimasa Iwate Medical University, 薬学部, 教授 (50160213)
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| Project Period (FY) |
2005 – 2009
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| Keywords | アポトーシス / anoikis / MEK阻害剤 / hypothemycin / BH3-only protein / Hsp90阻害剤 / anicequol / resorcylic acid lactones |
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| Research Abstract |
We searched for compounds that induce apoptosis in cancer cells only when cells are nonanchored (anoikis sensitizer). We found that MEK-inhibitors such as hypothemycin induce anoikis sensitivity in human cancer cells that rely heavily on the MEK-ERK pathway, and elucidated the molecular mechanism. We also discovered anicequol, HSP90 inhibitors, and sesquiterpene lactones as inhibitors of oncogenic signaling, and analyzed their mechanisms of action.
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Research Products
(21 results)
