2009 Fiscal Year Final Research Report
System analysis of stability and plasticity of signal transduction
| Project/Area Number |
17017005
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KURODA Shinya The University of Tokyo, 大学院・理学系研究科, 教授 (50273850)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATO Mitsuo 株式会社国際電気通信基礎技術研究所, 脳情報通信総合研究所, 所長 (10144445)
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| Project Period (FY) |
2005 – 2009
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| Keywords | システム生物学 / シグナル伝達 / シナプス可塑性 |
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| Research Abstract |
We analyzed the stability and plasticity of signaling transduction cascades. We have especially targeted synaptic plasticity. We developed a computational model of spike-timing dependent plasticity (STDP) in the cerebral cortex, and we found that a novel allosteic kinetics of NMDA receptors is required for STDP. The tectal neurons in the Xenopus tadpole can respond to moving visual stimuli in one preferred direction than in any other direction. Acquirement of direction selectivity has been shown to be mediated through the modification of synaptic connectivity by STDP. We proposed a mechanism for the acquirement of direction selectivity with computational models of STDP and a retino-tectal circuit.
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Research Products
(24 results)
