2009 Fiscal Year Final Research Report
The mechanism of molecular oscillation in animal development
| Project/Area Number |
17017027
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
BESSHO Yasumasa Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (70261253)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Takaaki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60403333)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 振動 / 波 / 体節 / 生物時計 / 形態形成 / シミュレーション / 転写因子 |
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| Research Abstract |
In this project, we charged mechanism of oscillatory gene expression in somite formation in vertebrate development. According to accumulated data of our molecular biological and biochemical experiments, we established a molecular model for the oscillatory gene expression. We analyzed this model by mathematical simulation in silico, and inspected it by molecular experiments. Our interdisciplinary approach revealed the mechanism of the oscillatory gene expression.
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[Journal Article] Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis.2011
Author(s)
Matsui T, Thitamadee S, Murata T, Kakinuma H, Nabetani T, Hirabayashi Y, Hirate Y, Okamoto H, 別所康全
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Journal Title
Proc.Natl.Acad.Sci.USA in press
Peer Reviewed
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[Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse.2009
Author(s)
Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
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Journal Title
PSM, PLoS ONE 4
Pages: e5603
Peer Reviewed
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