2009 Fiscal Year Final Research Report
Comparative Transcriptome Study of Brain
| Project/Area Number |
17018015
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Niigata University |
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Principal Investigator |
NAWA Hiroyuki Niigata University, 脳研究所, 教授 (50183083)
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| Co-Investigator(Kenkyū-buntansha) |
KAKITA Akiyoshi 新潟大学, 脳研究所, 准教授 (80281012)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 霊長類 / 進化 / ジンクフィンガー / 脳 / DNAマイクロアレイ |
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| Research Abstract |
Using the DNA microarray technique, we performed comparative expression profiling of brain transcriptomes among primates. The profiling revealed the marked strain variation in mRNA signal intensity or homology of the zinc finger genes located at human chromosome 19q13.43. DNA sequence analysis suggests that this genomic region has evolved rapidly in primates.
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[Journal Article] Molecular characterization and genedisruption of a novel zinc-finger protein,HIT-4, expressed in rodent brain.2010
Author(s)
Tanabe, Y., Hirano, A., Iwasato, T., Itohara S., Araki, A., Yamaguchi, T., Ichikawa, T., Kumanishi T., Aizawa, Y., Takahashi, H., Kakita, A., Nawa, H.
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Journal Title
J. Neurochemistry 112
Pages: 1035-1044
Peer Reviewed
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