2009 Fiscal Year Final Research Report
A study on the origin and evolution of multicellular animals
| Project/Area Number |
17018019
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
IWABE Naoyuki Kyoto University, 大学院・理学研究科, 助教 (80263060)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOH Hiroyuki 九州大学, 生体防御医学研究所, 教授 (70192656)
KUMA Kei-ichi 国立情報学研究所, 戦略研究プロジェクト創成センター, 教授 (10221938)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KATOH Kazutaka 九州大学, デジタルメディシンイニシアティブ, 准教授 (70378868)
OKADA Masato 大阪大学, 微生物病研究所, 教授 (10177058)
MIYATA Takashi JT, 生命誌研究館, 顧問 (20022692)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Keywords | 分子進化 / 多細胞化 / 立襟鞭毛虫 / ゲノム / 分子系統樹 / 生物多様性 / シグナル伝達系 / データベース |
|---|
| Research Abstract |
Choanoflagellates are single-celled small protists living in marine or freshwater. Most of the recent molecular phylogenetic analyses strongly suggested that choanoflagellate is one of the closest living relatives of animals (metazoans). Our research group has recently determined the whole genome shotgun (WGS) sequences of a choanoflagellate, Monosiga ovata. Comparative genome analysis of M. ovata with animals, fungi, slime mold and plants suggested that choanoflagellates possess a large number of genes that had been thought to be involved in 'animal-specific signal transduction pathways'. The analysis also indicated that most of the orthologous genes of 'animal-specific transcription factors' were not observed in the choanoflagellate genome.
|
-
-
-
-
[Journal Article] Ancient divergence of animal protein tyrosine kinase genes demonstrated by a gene family tree including choanoflagellate genes.2008
Author(s)
Suga, H., Sasaki, G., Kuma, K., Nishiyori, H., Hirose, N., Su, Z.H., Iwabe, N., Miyata, T.
-
Journal Title
FEBS Lett. 582(5)
Pages: 815-818
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.2006
Author(s)
Segawa, Y., Suga, H., Iwabe, N., Oneyama, C., Akagi, T., Miyata, T., Okada, M.
-
Journal Title
Proc. Natl. Acad. Sci. USA 103(32)
Pages: 12021-12026
Peer Reviewed
-
-
-
-
-
[Presentation] Genome sequencing project of a unicellular choanoflagellate, Monosiga ovata: Extensive molecular phylogenetic analysis with choanoflagellate genes reveals divergence patterns of gene family members in the early evolution of metazoans.2008
Author(s)
Iwabe, N., Kuma, K., Katoh, K., Suga, H., Hirose, N., Toh, H., Miyata, T., Suzuki, Y., Kasahara, M., Narita, T., Shin-i, T., Kuroki, Y., Toyoda, A., Sugano, S., Morishita, S., Kohara, Y., Fujiyama, A.
Organizer
XX International Congress of Genetics
Place of Presentation
Berlin, Germany(一般講演(ポスター発表:P121/18/B))
Year and Date
20080716-20080717
-
-
-
-
-
-
-
-
-
-
-
-
