Genome medical research supporting committee

2009 Fiscal Year Final Research Report

• Project/Area Number: 17019004
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Chiba University
• Principal Investigator: HATA Akira Chiba University, 大学院・医学研究院, 教授 (00244541)
• Co-Investigator(Kenkyū-buntansha): TSUJI Shioji 東京大学, 医学部附属病院, 教授 (70150612) ; KASUGA Masato 国立国際医療センター, 所長 (50161047) ; OKAZAKI Yuji (財)東京都医学研究機構, 東京都精神医学研究所, 研究員 (40010318) ; INOUE Ituro 東海大学, 医学部, 教授 (00192500) ; TAKEDA Masatoshi 大阪大学, 大学院・医学系研究科, 教授 (00179649) ; TOKUNAGA Katsushi 東京大学, 大学院・医学系研究科, 教授 (40163977) ; KUWANO Ryozo 新潟大学, 脳研究所, 教授 (20111734)
• Project Period (FY): 2005 – 2009
• Keywords: 遺伝子タイピング / ゲノム医学研究 / インフォームド・コンセント

Research Abstract

The aim of this study is to support human genome sample collectionand genome typing. Target diseases are common diseases including type 2 diabetes mellitus (DM), panic disorder, intracranial aneurysm, Alzheimer disease, and rarediseases such as multiple system atrophy. Main support of later half was a financial support for genotyping of genome-wide association study (GWAS). Through this support,genetic background of DM, Parkinson disease, intracranial aneurysm and other diseaseswas clarified.

Research Products

• [Journal Article] International web-based survey of informed consent procedures in genetic epidemiological studies: towards the establishment of a research coordinator accrefitation system. (2009)
  • Author(s): Yamamoto M, Funamizu M, Muto K, Hata A.
  • Journal Title: J Hum Genet. 54 Pages: 713-720
• [Journal Article] CD14 and IL4R gene polymorphisms modify the effect of day care attendance on serum IgE levels. (2009)
  • Author(s): Suzuki Y, Hattori S, Mashimo Y, Funamizu M, Kohno Y, Okamoto Y, Hata A, Shimojo N.
  • Journal Title: J Allergy Clin Immunol. 123 Pages: 1408-1411
• [Journal Article] Susceptibility loci for intracranial aneurysm in European and Japanese populations. (2008)
  • Author(s): Bilguvar K, Yasuno K, Niemela M,Ruigrok YM, von Und Zu Fraunberg M, vanDuijn CM, van den Berg LH, Mane S,Mason CE, Choi M, Gaal E, Bayri Y, KolbL, Arlier Z, Ravuri S, Ronkainen A,Tajima A, Laakso A, Hata A, Kasuya H,Koivisto T, Rinne J, Ohman J, BretelerMM, Wijmenga C, State MW, Rinkel GJ,Hernesniemi J, Jaaskelainen JE,Palotie A, Inoue I, Lifton RP, GunelM.
  • Journal Title: Nature Genet 40 Pages: 1472-1477
• [Journal Article] Heterozygous Deletion at 14q22. 1-q22. 3 including the BMP4 gene in a Patient with Psychomotor Retardation, Congenital Corneal Opacity and Feet Polysyndactyly. (2008)
  • Author(s): Hayashi S, Okamoto N, Yoshio Makita Y, Hata A, Imoto I, Inazawa J.
  • Journal Title: Am J Med Genet. 146A Pages: 2905-2910
• [Journal Article] The CASK gene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation. (2008)
  • Author(s): Hayashi S, Mizuno S, Migita O, Okuyama T, Makita Y, Hata A, Imoto I, Inazawa J.
  • Journal Title: Am J Med Genet. 146A Pages: 2145-2151
• [Remarks]
  • URL: http://www.genome-sci.jp/kumomaku/
• [Remarks]
  • URL: http://jshg.jp/qualifications/gmrc.html