Genetic study on Alzheimer Disease

2009 Fiscal Year Final Research Report

• Project/Area Number: 17019043
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: TAKEDA Masatoshi Osaka University, 医学系研究科, 教授 (00179649)
• Co-Investigator(Kenkyū-buntansha): MORIHARA Takeshi 大阪大学, 医学系研究科, 助教 (90403196) ; TANAKA Toshihisa 大阪大学, 医学系研究科, 講師 (10294068) ; AKATSU Hiroyasu 医療法人さわらび会福祉村病院, 長寿医学研究所, 副所長 (00399734) ; MAEDA Kiyoshi 神戸大学, 医学系研究科, 教授 (80116251) ; ARAI Heii 順天堂大学, 医学部, 教授 (50167988) ; NAKAJIMA Kenji 鳥取大学, 医学部, 教授 (70144673) ; YAMAGATA Hidehisa 愛媛大学, 医学系研究科, 講師 (00304618) ; TAGUCHI Keiko 愛媛大学, 医学系研究科, 助教 (20457378)
• Co-Investigator(Renkei-kenkyūsha): SHIBATA Nobuto 順天堂大学, 医学部, 講師 (50365615) ; YAMAMOTO Yasusji 神戸大学, 医学系研究科, 講師 (00324921) ; WADA kenji 愛媛大学, 医学系研究科, 講師 (60346351) ; KAMINO Koujin 大阪大学, 大学院・医学系研究科, 講師 (40307955) ; KIMURA Ryo 大阪大学, 大学院・医学系研究科, 大学院生 ; HAYASHI Noriyuki 大阪大学, 医学系研究科, 大学院生 ; YOKOKOJI Mikiko 大阪大学, 医学系研究科, 大学院生
• Project Period (FY): 2005 – 2009
• Keywords: アルツハイマー病 / 多因子疾患 / ゲノム

Research Abstract

We identified several candidate Alzheimer related genes using different approaches. DYRK1A was identified by genome scan in chromosome 21 and confirmed the importance by expression and functional analysis. Functional and expression analysis on DNM2, another AD candidate gene, was also performed. Expression analysis found PPP2R2B and confirmed by association study. We also searched amyloid modifier genes in AD model mice.

Research Products

• [Journal Article] Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism. (2009)
  • Author(s): Kamagata E, Kudo T, Kimura R, Tanimukai H, Morihara T, Sadik MG, Kamino K, Takeda M.
  • Journal Title: Biochem Biophys Res Commun. 379(3) Pages: 691-5
  • Peer Reviewed
• [Journal Article] Dementia in the Rural Island Town of Ama-cho, Japan. (2009)
  • Author(s): Wada-Isoe K, Uemura Y, Suto Y, Doi K, Imamura K, Hayashi A, Kitayama M, Watanabe Y, Adachi Y Nakashima K
  • Journal Title: Neuroepidemiology. 32(2) Pages: 101-106
  • Peer Reviewed
• [Journal Article] Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population. (2009)
  • Author(s): Shibata N, Ohnuma T, Baba H, Arai H.
  • Journal Title: Dement Geriatr Cogn Disord. 28(4) Pages: 325-9
  • Peer Reviewed
• [Journal Article] ssociation between polymorphisms of heme oxygenase 1 and 2 and Alz heimer's disease in a Japanese population. (2009)
  • Author(s): Shibata N, Ohnuma T, Baba H, Arai H.
  • Journal Title: Dement Geriatr Cogn Disord. 27(3) Pages: 273-7
  • Peer Reviewed
• [Journal Article] Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein. (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Kudo T, Takeda M
  • Journal Title: Commun 22 383(1) Pages: 37-41
  • Peer Reviewed
• [Journal Article] Involvement of puromycine-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of FTDP-17 mutant tau. (2009)
  • Author(s): Yanagi K, Tanaka T, Kato K, Sadik G,, Morihara T, Kudo T, Takeda M
  • Journal Title: Psycogeriatrics (in press)
  • Peer Reviewed
• [Journal Article] Novel therapeutic strategies for neurodegenerative disease. (2009)
  • Author(s): Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M.
  • Journal Title: Psychogeriatrics. 9 Pages: 103-109
  • Peer Reviewed
• [Journal Article] Prevention of psychiatric illness in the elderly I -Path to Prevention of Dementia (2009)
  • Author(s): Tanaka T, Kazui H, Sadik G, Tanimukai H, Tagami S, Morihara T, Okochi M, Kudo K, Takeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 111-115
  • Peer Reviewed
• [Journal Article] Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein. (2009)
  • Author(s): Ito S, Nakaso K, Imamura K, Takeshima T, Nakashima K
  • Journal Title: Neurosci Res. inpress(in press)
  • Peer Reviewed
• [Journal Article] Validation of the Parkinson's disease sleep scale in Japanese patients: a comparison study using the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale and Polysomnography. (2009)
  • Author(s): Uemura Y, Nomura T, Inoue Y, Yamawaki M, Yasui K, Nakashima K
  • Journal Title: J Neurol Sci. Dec 15;287(1-2) Pages: 36-40
  • Peer Reviewed
• [Journal Article] Long-term prognosis of patients with large subcortical infarctions. (2009)
  • Author(s): Suto Y, Nakayasu H, Maeda M, Kusumi M, Kowa H, Awaki E, Saito J, Nakashima K.
  • Journal Title: Eur Neurol. 62(5) Pages: 304-10
  • Peer Reviewed
• [Journal Article] Aassessment of dementia in patients with multiple system atrophy Kitayama M (2009)
  • Author(s): Wada-Isoe K, Irizawa Y, Nakashima K.
  • Journal Title: Eur J Neurol. 16(5) Pages: 589-94
  • Peer Reviewed
• [Journal Article] Changes in prevalence and incidence of Parkinson's disease in Japan during a quarter of a century. (2009)
  • Author(s): Yamawaki M, Kusumi M, Kowa H, Nakashima K.
  • Journal Title: Neuroepidemiology. 32(4) Pages: 263-9
  • Peer Reviewed
• [Journal Article] Neuropsychological profile of dementia with Lewy bodies (2009)
  • Author(s): Haruhiko Oda, Yasuji Yamamoto, Kiyoshi Maeda
  • Journal Title: PSYCHOGERIATRICS Pages: 85-90
  • Peer Reviewed
• [Journal Article] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. (2009)
  • Author(s): Sadik G, Tanaka T, Kato K, Yamamori H, Nessa BN, Morihara T, Takeda M.
  • Journal Title: J Neurochem 108(1) Pages: 33-43
  • Peer Reviewed
• [Journal Article] Association Study of RGS2 Gene Polymorphisms with Panic Disorder in Japanese. (2009)
  • Author(s): Mouri K, Hishimoto A, Fukutake M, Shirakawa O, Nishiguchi N, Maeda K.
  • Journal Title: Kobe Journal of Medical Sciences (in press)
  • Peer Reviewed
• [Journal Article] TPH2 is not a susceptibility gene for suicide in Japanese population. (2009)
  • Author(s): Mouri K, * *_Hishimoto A, _ Fukutake M, Shiroiwa K, Asano M, Nagasaki Y, Ueno Y, Shirakawa O, Nishiguchi N, Maeda K.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33(8) Pages: 1546-1550
  • Peer Reviewed
• [Journal Article] Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease. (2009)
  • Author(s): Okita K, Matsukawa N, Maki M, Nakazawa H, Katada E, Hattori M, Akatsu H, Borlongan CV, Ojika K.
  • Journal Title: Biochem Biophys Res Commun. 379(2) Pages: 272-6
  • Peer Reviewed
• [Journal Article] Association between quality of life of demented patients and professional knowledge of care workers. (2008)
  • Author(s): Kazui H, Harada K, Eguchi YS, Tokunaga H, Endo H, Takeda M.
  • Journal Title: J Geriatr Psychiatry Neurol 21(1) Pages: 72-8
  • Peer Reviewed
• [Journal Article] Hemispatial visual defect in Alzheimer's disease. (2008)
  • Author(s): Oda H, Ohkawa S, Maeda K
  • Journal Title: NEUROCASE 14(2) Pages: 141-146
  • Peer Reviewed
• [Journal Article] The neuropsychological profile in dementia with Lewy bodies and Alzheimer's deisease (2008)
  • Author(s): H Oda, Y Yamamoto, K Maeda
  • Journal Title: Int J Geriaty Psychiatry 23 Pages: 1-7
  • Peer Reviewed
• [Journal Article] A molecular chaperone inducer protects neurons from ER stress. (2008)
  • Author(s): Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K, Takeda M.
  • Journal Title: Cell Death Differ. 15(2) Pages: 364-75
  • Peer Reviewed
• [Journal Article] Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-ε4 carriers Aidaralieva (2008)
  • Author(s): N, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, et al
  • Journal Title: J Hum Genet 53(4) Pages: 296-302
  • Peer Reviewed
• [Journal Article] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease. (2008)
  • Author(s): Taniguchi, M., Okayama, Y., Hashimoto, Y., Kitaura, M., Jimbo, D., Wakutani, Y., Wada-Isoe, K., Nakashima, K., Akatsu, H., Furukawa, K., Arai, H., Urakami, K. Dement
  • Journal Title: Geriatr Cogn Disord. 26(2) Pages: 117-22
  • Peer Reviewed
• [Journal Article] A functional polymorphism of theμ-opioid receptor gene is associated with completed suicides Akitoyo Hishimoto (2008)
  • Author(s): Huxing Cui, Kentarou Mouri, Hideyuki Nushida, Yasuhiro Ueno, Kiyoshi Maeda, Osamu Shirakawa
  • Journal Title: J Neural Transmission 115 Pages: 531-536
  • Peer Reviewed
• [Journal Article] Association of RGS2 Gene Polymorphisms with Suicide and Increased RGS2 Immunoreactivity in the Postmortem Brain of Suicide Victims (2008)
  • Author(s): Huxing Cui, Naoki Nishiguchi, Elene Ivleva, Masaya Yanagi, Masaaki Fukutake, H Nushida, Y Ueno, Noboru Kitamura, Kiyoshi Maeda, Osamu Shirakawa
  • Journal Title: Neuropsychopharmacology 33(7) Pages: 1537-1544
  • Peer Reviewed
• [Journal Article] Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia. (2008)
  • Author(s): Masaya Yanagi, Takeshi Hashimoto, Noboru Kitamura, Masaaki Fukutake, Osamu Komure, Naoki Nishiguchi, Toshio Kawamata, Kiyoshi Maeda, Osamu Shirakawa
  • Journal Title: Schizophr Res 100 Pages: 291-301
  • Peer Reviewed
• [Journal Article] of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females. (2008)
  • Author(s): Fukutake M, Hishimoto A, Nishiguchi N, Nushida H, Ueno Y, Shirakawa O, Maeda K. Prog
  • Journal Title: Neuropsychopharmacol Biol Psychiatry. 32(6) Pages: 1428-33
  • Peer Reviewed
• [Journal Article] Event-related synchronization of alpha activity in early Alzheimer's disease and mild cognitive impairment: an MEG study combining beamformer and group comparison. (2008)
  • Author(s): Kurimoto R, Ishii R, Canuet L, Ikezawa K, Azechi M, Iwase M, Yoshida T, Kazui H, Yoshimine T, Takeda M.
  • Journal Title: Neurosci Lett. 443(2) Pages: 86-9
  • Peer Reviewed
• [Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 (2008)
  • Author(s): Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, et al
  • Journal Title: Mol Cell Biol 28(1) Pages: 165-76
  • Peer Reviewed
• [Journal Article] Association of visual hallucinations with reduction of MIBG cardiac uptake in Parkinson's disease. (2008)
  • Author(s): Kitayama M, Wada-Isoe K, Irizawa Y, Nakashima K.
  • Journal Title: J Neurol Sci 264(1-2) Pages: 22-6
  • Peer Reviewed
• [Journal Article] Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus. (2008)
  • Author(s): Kubo Y, Kazui H, Yoshida T, Kito Y, Kimura N, Tokunaga H, Ogino A, Miyake H, Ishikawa M, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord 25(1) Pages: 37-45
  • Peer Reviewed
• [Journal Article] Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. (2008)
  • Author(s): Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA.
  • Journal Title: J Pharmacol Exp Ther 326(1) Pages: 196-208
  • Peer Reviewed
• [Journal Article] Possible association between SORL1 and Alzheimer disease? Reanalysing the data of Shibata, et al. (2008)
  • Author(s): Lee JH, Shibata N, Cheng R, Mayeux R.
  • Journal Title: Dement Geriatr Cogn Disord. 26(5) Pages: 482
  • Peer Reviewed
• [Journal Article] Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. (2008)
  • Author(s): Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H.
  • Journal Title: Dement Geriatr Cogn Disord 26(2) Pages: 161-4
  • Peer Reviewed
• [Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase. (2008)
  • Author(s): Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
  • Journal Title: Neurodegener Dis 5(3-4) Pages: 160-2
  • Peer Reviewed
• [Journal Article] Identification of homozygous deletions of the tumor suppression gene FAT in oral cancer using CGH-array (2007)
  • Author(s): Nakaya, K., Yamagata, HD., Arita, N., Nakashiro, K-I., Nose, M., Miki, T., Hamakawa, H.
  • Journal Title: Oncogene. Aug 26(36) Pages: 5300-8
  • Peer Reviewed
• [Journal Article] The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. (2007)
  • Author(s): Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, et al
  • Journal Title: Hum Mol Genet. 16(1) Pages: 15-23
  • Peer Reviewed
• [Journal Article] Clinical evaluation of Parkinson's disease dementia: association with aging and visual hallucination. (2007)
  • Author(s): Kitayama M, Wada-Isoe K, Nakaso K, Irizawa Y, Nakashima K.
  • Journal Title: Acta Neurol Scand. 116(3) Pages: 190-5
  • Peer Reviewed
• [Journal Article] The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. (2007)
  • Author(s): Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T
  • Journal Title: J Biol Chem. 282(7) Pages: 4916-23
  • Peer Reviewed
• [Journal Article] n-Specific Expression of the TAF1 Gene Is Associated with X-Linked Dystonia-Parkinsonism. (2007)
  • Author(s): Makino S, Kaji R, Ando S, Tomizawa M, Yasuno K, Goto S, Matsumoto S, Tabuena MD, Maranon E, Dantes M, et al
  • Journal Title: Am J Hum Genet. 80(3) Pages: 393-406
  • Peer Reviewed
• [Journal Article] Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. (2007)
  • Author(s): Nakai M, Fujita M, Waragai M, Sugama S, Wei J, Akatsu H, Ohtaka-Maruyama C, Okado H, Hashimoto M.
  • Journal Title: Biochem Biophys Res Commun. 358(1) Pages: 104-10
  • Peer Reviewed
• [Journal Article] Genetic association between Notch4 polymorphisms and Alzheimer's disease in the Japanese population. (2007)
  • Author(s): Shibata N, Ohnuma T, Higashi S, Higashi M, Usui C, Ohkubo T, Watanabe T, Kawashima R, Kitajima A, Ueki A, et al
  • Journal Title: J Gerontol A Biol Sci Med Sci. 62(4) Pages: 350-1
  • Peer Reviewed
• [Journal Article] nepezil in the treatment of musical hallucinations. (2007)
  • Author(s): Ukai S, Yamamoto M, Tanaka M, Shinosaki K, Takeda M.
  • Journal Title: Psychiatry Clin Neurosci 61(2) Pages: 190-2
  • Peer Reviewed
• [Journal Article] Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy study. (2007)
  • Author(s): Wada-Isoe K*, Kitayama M, Nakaso K, Nakashima K.
  • Journal Title: J Neurol Sci. 260(1-2) Pages: 33-7
  • Peer Reviewed
• [Journal Article] Serum proteomic profiling of dementia with Lewy bodies: diagnostic potential of SELDI-TOF MS analysis. (2007)
  • Author(s): Wada-Isoe K, Michio K, Imamura K, Nakaso K, Kusumi M, Kowa H, Nakashima K. J
  • Journal Title: Neural Transm. 114(12) Pages: 1579-83
  • Peer Reviewed
• [Journal Article] Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. (2007)
  • Author(s): Goodenowe DB, Cook LL, Liu J, Lu Y, Jayasinghe DA, Ahiahonu PW, Heath D, Yamazaki Y, Flax J, Krenitsky KF, et al
  • Journal Title: J Lipid Res 48(11) Pages: 2485-98
  • Peer Reviewed
• [Journal Article] Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. (2007)
  • Author(s): Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM.
  • Journal Title: Neurosci 27(52) Pages: 14299-307
  • Peer Reviewed
• [Journal Article] A novel alternative splice variant of nicastrin and its implication in Alzheimer diseaseMitsuda, N., Yamagata, HD., Zhong, W. (2006)
  • Author(s): Akatsu, H., Uekawa, N., Kamino, K., Taguchi, K., Yamamoto, T., Maruyama, M., Kosaka, K., et al.
  • Journal Title: Life Sciences 78(21) Pages: 2444-2448
  • Peer Reviewed
• [Journal Article] Albumin gene encoding FFA and beta amyloid transporter is a risk gene for Alzheimer disease. (2006)
  • Author(s): Kimura, R., Kamino, K., Yamamoto, M., Akatsu, H., Uema, T., Kobayashi, T., Hattori, H., Nuripa, A., Nessa, B., Kudo, T., et al.
  • Journal Title: Psyichiat Clin Neurosci 60 Pages: S34-S39
  • Peer Reviewed
• [Journal Article] Variation in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan Akatsu (2006)
  • Author(s): H., Yamagata, HD., Kawamata, J., Kamino, K., Takeda, M., Yamamoto, T., Miki, T., Tooyama, I., Shimohama, S., Kosaka, K. Dement
  • Journal Title: Geriatr Cogn Disord 22(3) Pages: 216-222
  • Peer Reviewed
• [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells Nessa, B.N., Tanaka (2006)
  • Author(s): T., Kamino, K., Sadik, G., Ansar, A.B., Kimura, R., Tanii, H., Okochi, M., Morihara, T., Tagami, S., et al.
  • Journal Title: Psyichiat Clin Neurosci 60 Pages: S27-S33
  • Peer Reviewed
• [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct. (2006)
  • Author(s): Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino, K, et al.
  • Journal Title: Biochemistry 45(15) Pages: 4907-4914
  • Peer Reviewed
• [Journal Article] Neurobiological studies of dementia-biological markers and neuroprotective strategies for Alzheimer disease. (2006)
  • Author(s): Tanaka T, Isoe-Wada K, Yamamori H, Kato K, Nessa BN, Sadik GM, Takeda M.
  • Journal Title: Acta Neurol Taiwan 15(1) Pages: 68-71
  • Peer Reviewed
• [Journal Article] The heterogeneity and natural history of mild cognitive impairment. (2005)
  • Author(s): Frisoni GB, Geroldi C, Binetti G, Zanetti O
  • Journal Title: Jan 62(1) Pages: 163
  • Peer Reviewed
• [Journal Article] Evaluation of a computerized test system to screen for mild cognitive impairment. (2005)
  • Author(s): Inoue M, Nakashima K, et al.
  • Journal Title: psychogeriatrics 5 Pages: 36-41
  • Peer Reviewed
• [Journal Article] Alpha-synuclein-positive structures induced in leupeptin-infused rats. (2005)
  • Author(s): Nakajima T, Takauchi S, Ohara K, Kokai M, Nishii R, Maeda S, Takanaga A, Tanaka T, Takeda M, Seki M, Morita Y.
  • Journal Title: Brain Res. 1040(1-2) Pages: 73-80
  • Peer Reviewed
• [Journal Article] Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix. (2005)
  • Author(s): Satoh K, Hata M, Shimizu T, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T.
  • Journal Title: Biochem Biophys Res Commun. 335(2) Pages: 631-6
  • Peer Reviewed
• [Journal Article] Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease. (2005)
  • Author(s): Shibata N, Ohnuma T, Higashi S, Usui C, Ohkubo T, Kitajima A, Ueki A, Nagao M, Arai H.
  • Journal Title: Neurobiol Aging. 26(7) Pages: 1011-4
  • Peer Reviewed
• [Journal Article] Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease. (2005)
  • Author(s): Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S.
  • Journal Title: J Neural Transm. 112(5) Pages: 703-11
  • Peer Reviewed
• [Journal Article] Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura. (2005)
  • Author(s): Kowa H, Fusayasu E, Ijiri T, Ishizaki K, Yasui K, Nakaso K, Kusumi M, Takeshima T, Nakashima K.
  • Journal Title: Neurosci Lett. 374(2) Pages: 129-31
  • Peer Reviewed
• [Journal Article] Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease. (2005)
  • Author(s): Hamaguchi T,Kitamoto T, Sato T, Mizusawa H, Nakamura Y,Noguchi M, Furukawa Y, Ishida C, Kuji I,Mitani K, Murayama S, Kohriyama T, KatayamaS, Yamashita M, Yamamoto T, Udaka F, KawakamiA, Ihara Y, Nishinaka T, Kuroda S, Suzuki N,Shiga Y, Arai H, Maruyama M, Yamada M.
  • Journal Title: Neurology. 64(4) Pages: 643-8
  • Peer Reviewed
• [Journal Article] Risk of falls in Alzheimer's disease: a prospective study. (2005)
  • Author(s): Horikawa E, Matsui T, Arai H, Seki T, Iwasaki K, Sasaki H.
  • Journal Title: Intern Med. 44(7) Pages: 717-21
  • Peer Reviewed
• [Journal Article] Identification of hippocampus-related candidate genes for Alzheimer's disease. (2005)
  • Author(s): Taguchi K, Yamagata H, Zhong W, Kamino K, Akatsu H, Hata R, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T.
  • Journal Title: Ann Neurol 57(4) Pages: 585-8
  • Peer Reviewed
• [Journal Article] Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. (2004)
  • Author(s): Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J, Yokoyama S, Yamamoto T, Kosaka K, Miki T, Kondo I.
  • Journal Title: Biochem Biophys Res Commun 321 Pages: 320-3
  • Peer Reviewed
• [Journal Article] C677T polymorphism of methylenetetrahydrofolate reductase gene affects plasma homocysteine level and is a genetic factor of late-onset Alzheimer's disease. (2004)
  • Author(s): Kida T, Kamino K, Yamamoto M, Kanayama D, Tanaka T, kudo T, Takeda M.
  • Journal Title: PSYCHOGERIATRICS 4 Pages: 4-10
  • Peer Reviewed
• [Journal Article] TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction. (2004)
  • Author(s): Akatsu H, Yamagata H, Chen Y, Miki T, Kamino K, Takeda M, Campbell W, Kondo I, Kosaka K, Yamamoto T, Okada H.
  • Journal Title: British J Haematology 127 Pages: 440-447
  • Peer Reviewed
• [Journal Article] Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease. (2004)
  • Author(s): Marui W, Iseki E, Kato M, Akatsu H, Kosaka K.
  • Journal Title: Acta Neuropathol. 108(2) Pages: 121-8
  • Peer Reviewed
• [Journal Article] Increased incidence of dementia with Lewy bodies in patients carrying the e4-allele of apolipoprotein E. (2004)
  • Author(s): Akatsu H, Kamino K, Yamagata H, Isojima D, Kondo I, Yamamoto T, Kida T, Takeda M, Miki T, Kosaka K.
  • Journal Title: PSYCHOGERIATRICS 4 Pages: 23-32
  • Peer Reviewed
• [Presentation] Genetic Study on Alzheimer Disease (2009)
  • Author(s): Rio de Janeiro
  • Organizer: 2009 International Meeting of the International Psychogeriatric Association Symposist
  • Place of Presentation: Brazil
  • Year and Date: 20090504-20090507
• [Presentation] Risk Genes for Dementia (2008)
  • Author(s): シンポジスト
  • Organizer: 神経化学学会2008
  • Place of Presentation: 富山
  • Year and Date: 20080911-20080913
• [Presentation] Drastic Impact on Abeta Accumulation in APP Tg Mice By Genetic Background. (2008)
  • Author(s): MORIHARA T, YOKOKOJI M, HAYASHI N, NOSHI E, MORI K, TAGAMI S, KUDO T, KAMINO K, TAKEDA M
  • Organizer: ICAD 2008
  • Place of Presentation: Chicago USA
  • Year and Date: 20080726-20080731