2009 Fiscal Year Final Research Report
Genome-wide study on pathogenesis of bacteria causing nosocomial infection
| Project/Area Number |
17019048
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUGAI Motoyuki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (10201568)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Naomasa 京都薬科大学, 薬学部, 教授 (30121560)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 黄色ブドウ球菌 / 緑膿菌 / セラチア / 病原性 / マイクロアレイ |
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| Research Abstract |
We employed Staphylococcus aureus, Serratia marcescens, Pseudomonas aeruginosa as target agent causing nosocomial infection. For S. aureus, we delineated gene sets present in S. aureus causing certain diseases and analyzed candidate genes to detect or foresee specific virulence of S. aureus. For S. marcescens, we screened for virulence-related genes by animal experiment and investigated for factors (genes) involved in human serum resistance. For P. aeruginosa, we investigated for factors (genes) involved in human serum resistance. We also analyzed characteristics and antimicrobial resistance mechanism of MDRP clones.
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[Journal Article] Staphylococcus aureus MazF specifically cleaves pentad sequence UACAU, which is unusually highly abundant in the pathogenic adhesive factor Srap2009
Author(s)
Zhu, L., Inoue, K., Yoshizumi, S., Kobayashi, H., Ouyang, M., Kato, F., Sugai, M., Inouye, M
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Journal Title
Journal of Bacteriology 191
Pages: 3248-3255
Peer Reviewed
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