Elucidation of visual cortical development by integrative approach

2009 Fiscal Year Final Research Report

• Project/Area Number: 17021047
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TAKAO Hensch The Institute of Physical and Chemical Research, 神経回路発達研究チーム, チームリーダー (60300878)
• Co-Investigator(Kenkyū-buntansha): KANZAKI Yukari 独立行政法人理化学研究所, 神経回路発達研究チーム, 研究員 (80391928) ; FAGIOLINI Michela 独立行政法人理化学研究所, 神経回路発達研究チーム, 研究員 (20332330) ; PIERO Carninci 独立行政法人理化学研究所, ゲノム機能研究チーム, チームリーダー (10333296)
• Project Period (FY): 2005 – 2009
• Keywords: 臨界期 / 視覚 / マイクロアレイ / GABA / 大脳発達 / パルブアルブミン

Research Abstract

The goal of this research is to assemble and analyze a microarray of genes that are expressed during critical periods of brain development, when the environment can flexibly reshape neural circuits. By confirming morphogenic molecules in particular inhibitory cell types, we elucidated mechanisms of brain function development through an integrated molecular and neurophysiological approach. For example, the discovery of novel functions for the Otx2 homeoprotein, as well as molecular "brakes" on the critical period represented by myelin factors, will be a key to therapeutically reopening brain plasticity in adulthood.

Research Products

• [Journal Article] Bidirectional plasticity in fast-spiking GABA circuits by visual experience. (2009)
  • Author(s): Yazaki-Sugiyama Y., Kang S., Kato H., Fukai T., Hensch T.K.
  • Journal Title: Nature 462,No.7270 Pages: 218-221
  • Peer Reviewed
• [Journal Article] 生まれてから変化する柔軟な脳 (2009)
  • Author(s): 俣賀宣子, Hensch T.K.
  • Journal Title: 「生る」生命誌年刊号 Vol.53-56 Pages: 135-141
• [Journal Article] Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity (2008)
  • Author(s): Sugiyama S., Di Nardo A.A., Aizawa S., Matsuo I., Volovitch M., Prochiantz A., Hensch T.K.
  • Journal Title: Cell 134,No.3 Pages: 508-520
  • Peer Reviewed
• [Journal Article] A resource for transcriptomic analysis in the mouse brain (2008)
  • Author(s): Plessy C., Fagiolini M., Wagastuma A., Harasawa N., Kuji T., Oba A., Kanzaki Y., Waki K., Nakahara H., Hensch T.K., Carninci P.
  • Journal Title: PLoS One 3,No.8 Pages: e3012-1-e3012-10
  • Peer Reviewed
• [Journal Article] Optimization of somatic inhibition at critical period onset in mouse visual cortex (2007)
  • Author(s): Katagiri H., Fagiolini M., Hensch T.K.
  • Journal Title: Neuron 53,No.6
  • Peer Reviewed
• [Journal Article] 視覚野「臨界期」の分子・細胞メカニズム (2006)
  • Author(s): 俣賀宣子, Hensch T.K.
  • Journal Title: 実験医学 24,No.15 Pages: 40-46
• [Journal Article] Critical period plasticity in local cortical circuits (2005)
  • Author(s): Hensch T.K.
  • Journal Title: Nature Rev. Neurosci 6 Pages: 877-888
  • Peer Reviewed
• [Journal Article] Critical Period Mechanisms in Developing Visual Cortex (2005)
  • Author(s): Hensch T.K.
  • Journal Title: Curr. Topics Dev. Biol. 69 Pages: 215-237
  • Peer Reviewed
• [Presentation] Critical period plasticity in the visual and auditory systems (2010)
  • Author(s): Hensch T.K.
  • Organizer: 6th NIBB Conference on Neocortical Organization
  • Place of Presentation: 岡崎
  • Year and Date: 20100300
• [Presentation] 経験に依存する脳の形成メカニズム (2009)
  • Author(s): Hensch T.K.
  • Organizer: 平成21年度文部科学省特定領域研究「統合脳」冬の公開シンポジウム, 文部科学省特定領域研究「統合脳」5領域
  • Place of Presentation: 東京
  • Year and Date: 20091200
• [Presentation] Automated analysis of dendritic protrusions from reconstructed confocal images (2009)
  • Author(s): 矢野和佳子, 俣賀宣子, 佐藤康平, 青木義満, 大関和夫, Hensch T.K.
  • Organizer: 第32回日本神経科学大会, 日本神経科学学会
  • Place of Presentation: 名古屋
  • Year and Date: 20090900
• [Presentation] 総合的研究手法による大脳視覚野形成機構の解明 (2009)
  • Author(s): 杉山陽子, Hensch T.K.
  • Organizer: 平成21年度文部科学省特定領域研究「統合脳」夏のワークショップ, 文部科学省特定領域研究「統合脳」5領域
  • Place of Presentation: 札幌
  • Year and Date: 20090800
• [Presentation] Critical Period Revisited - brain plasticity in adulthood (2009)
  • Author(s): Hensch T.K.
  • Organizer: McDonnell-RIKEN Symposium, McDonnell Foundation
  • Place of Presentation: 和光
  • Year and Date: 20090600
• [Presentation] GABA circuit control of critical period plasticity (2008)
  • Author(s): Hensch T.K.
  • Organizer: Mini-Symposium: Development and Plasticity of the Brain
  • Place of Presentation: Osaka University, Suita
  • Year and Date: 20080800
• [Presentation] Excitatory inputs reflect critical period plasticity in visual cortex (2008)
  • Author(s): 俣賀宣子, Hensch T.K.
  • Organizer: 第31回日本神経科学大会(Neuroscience 2008)
  • Place of Presentation: 東京
  • Year and Date: 20080700
• [Presentation] Molecular mechanisms of critical period reactivation (2007)
  • Author(s): Hensch T.K.
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会(BMB2007)
  • Place of Presentation: 横浜
  • Year and Date: 20071200
• [Presentation] Gene expression profiling for the single population of interneuron in mouse cortex (2007)
  • Author(s): Wagatsuma A., Kuji T., Oba A., Carninci P., Hensch T.K.
  • Organizer: 37th Annual Meeting of Society for Neuroscience (Neuroscience 2007)
  • Place of Presentation: San Diego, USA
  • Year and Date: 20071100
• [Presentation] Covalent modifications of chromatin regulate critical period plasticity in visual cortex (2007)
  • Author(s): Sng J.C., Lennartsson A., Carninci P., Fagiolini M., Hensch T.K.
  • Organizer: 7th Annual Meeting of Society for Neuroscience (Neuroscience 2007)
  • Place of Presentation: San Diego, USA
  • Year and Date: 20071100
• [Presentation] Orientation tuning by NR2A signaling in mouse visual cortex (2007)
  • Author(s): Dur, S., Atapour N., Hensch T.K.
  • Organizer: 37th Annual Meeting of Society for Neuroscience (Neuroscience 2007)
  • Place of Presentation: San Diego, USA
  • Year and Date: 20071100
• [Presentation] Inhibitory circuit control of critical period plasticity (2007)
  • Author(s): Hensch T.K.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 20070900
• [Presentation] Epigenetic regulation of critical period plasticity in visual cortex (2007)
  • Author(s): Sng J.C., Lennartsson A., Fagiolini M., Carninci P., Hensch T.K.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 20070900
• [Presentation] Orientation tuning in mouse visual cortex (2007)
  • Author(s): Dur, S., Hensch T.K.
  • Organizer: 7th IBRO World Congress of Neuroscience (IBRO 2007)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 20070700
• [Presentation] Dynamic role of inhibition during visual cortical plasticity in mice (2007)
  • Author(s): Yazaki-Sugiyama Y., Hensch T.K.
  • Organizer: 2007 Gordon Research Conference on Neural Circuits and Plasticity
  • Place of Presentation: Newport, USA
  • Year and Date: 20070700
• [Presentation] Orientation tuning in mouse visual cortex (2007)
  • Author(s): Dur, S., Hensch T.K.
  • Organizer: 7th IBRO WORLD CONGRESS OF NEUROSCIENCE
  • Place of Presentation: elbourne, Australia
  • Year and Date: 20070700
• [Presentation] Critical period mechanisms of visual cortical plasticity (2007)
  • Author(s): Hensch T.K.
  • Organizer: NIH Neuroscience Seminar Series/Guroff Memorial Lecture, National Institutes of Health
  • Place of Presentation: Bethesda, USA
  • Year and Date: 20070400
• [Presentation] Critical period mechanisms of visual cortical Plasticity (2007)
  • Author(s): Hensch T.K.
  • Organizer: NIH Neuroscience Seminar Series/Guroff Memorial Lecture, (National Institutes of Health)
  • Place of Presentation: Bethesda, USA
  • Year and Date: 20070400
• [Presentation] 大脳皮質の発達可塑性に関わるプロテアーゼ (2007)
  • Author(s): 俣賀宣子, Hensch T.K.
  • Organizer: 奈良先端科学技術大学院大学 バイオサイエンス研究科COEセミナー
  • Place of Presentation: 生駒
  • Year and Date: 20070300
• [Presentation] Mechanisms of critical period plasticity (2007)
  • Author(s): Hensch T.K.
  • Organizer: システム神経生物学スプリングスクール「神経情報処理と発達」(奈良先端技術大学院大学)
  • Place of Presentation: 生駒
  • Year and Date: 20070300
• [Presentation] Specific Inhibitory Circuit Control of Visual Cortical Plasticity (2006)
  • Author(s): Fagiolini M.
  • Organizer: 36th Annual Meeting of Society for Neuroscience (Neuroscience 2006)
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061000
• [Presentation] Neuroethics of Nurturing the Brain (2006)
  • Author(s): Hensch T.K.
  • Organizer: 6th Annual Meeting of Society for Neuroscience (Neuroscience 2006)
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061000
• [Presentation] Sequential role of AMPA receptor subunits in ocular dominance plasticity (2006)
  • Author(s): Iwai Y., Atapour N., Renger J., Roder J., Seeburg P., Hensch T.K.
  • Organizer: 36th Annual Meeting of Society for Neuroscience (Neuroscience 2006)
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061000
• [Presentation] Distinct mechanisms underlie adult perceptual learning and classical ocular dominance plasticity in mouse visual cortex (2006)
  • Author(s): Miyamoto H., Surti T., Mishina M., Hensch T.K.
  • Organizer: 36th Annual Meeting of Society for Neuroscience (Neuroscience 2006)
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061000
• [Presentation] Full-length cDNA microarray analysis of critical period closure in mouse visual cortex (2006)
  • Author(s): Hensch T.K., Fagiolini M., Kanzaki Y., Plessy C., Oba A., Wagatsuma A., Kuji T., Nakamura M., Kishikawa T., Chung M.H., Carninci P.
  • Organizer: 36th Annual Meeting of Society for Neuroscience (Neuroscience 2006)
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061000
• [Presentation] CNR/Protocadherin-α slows ocular dominance plasticity in mouse visual cortex (2006)
  • Author(s): Morishita H., Kumode Y., Hamada S., Yagi T., Hensch T.K.
  • Organizer: 36th Annual Meeting of Society for Neuroscience (Neuroscience2006)
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061000
• [Presentation] Neuroethics of Nurturing the Brain (2006)
  • Author(s): Hensch T.K.
  • Organizer: 36th Annual Meeting of Society for Neuroscience (Neuroscience 2006)
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061000
• [Presentation] Otx2 specification of critical period plasticity in mouse visual cortex (2006)
  • Author(s): Hensch T.K.
  • Organizer: 16th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN 2006)
  • Place of Presentation: Banff, Canada
  • Year and Date: 20060800
• [Presentation] Distinct mechanisms underlie adult perceptual learning and classical ocular dominance plasticity in mouse visual cortex (2006)
  • Author(s): 宮本浩行, Surti T.S., Hensch T.K.
  • Organizer: 第29回日本神経科学大会(Neuroscience 2006)
  • Place of Presentation: 京都
  • Year and Date: 20060700
• [Presentation] Experience-dependent plasticity in the absence of AMPA receptor subunits in mouse visual cortex (2006)
  • Author(s): 岩井陽一, Atapour N., Renger J., Roder J., Seeburg P., Hensch T.K.
  • Organizer: 第29回日本神経科学大会(Neuroscience 2006)
  • Place of Presentation: 京都
  • Year and Date: 20060700
• [Presentation] Myelination signals critical period closure in visual cortex (2006)
  • Author(s): Fagiolini M., Chung M.H., Miyamoto H., He Z., Hensch T.K.
  • Organizer: 5th Forum of European Neuroscience (FENS Forum 2006)
  • Place of Presentation: The Federation of European Neuroscience Societies, Vienna, Austria
  • Year and Date: 20060700
• [Presentation] Distinct mechanisms underlie adult perceptual learning and classical ocular dominance plasticity in mouse visual cortex (2006)
  • Author(s): Miyamoto H., Surti T., Hensch T.K.
  • Organizer: 5th Forum of European Neuroscience (FENS Forum 2006)
  • Place of Presentation: The Federation of European Neuroscience Societies, Vienna, Austria
  • Year and Date: 20060700
• [Presentation] Critical period mechanisms in visual cortex (2006)
  • Author(s): Hensch T.K.
  • Organizer: 5th Forum of European Neuroscience (FENS Forum 2006)
  • Place of Presentation: The Federation of European Neuroscience Societies, Vienna, Austria
  • Year and Date: 20060700
• [Presentation] Critical period specification by Otx2 homeoprotein in postnatal visual cortex (2006)
  • Author(s): Hensch T.K.
  • Organizer: Friedrich Miescher Institute (FMI) for Biomedical Research Lectures on Neuronal Circuits
  • Place of Presentation: Basel, Switzerland
  • Year and Date: 20060500
• [Presentation] 大脳皮質の発生と機能構築 (2006)
  • Author(s): Hensch, T.K.
  • Organizer: 基礎生物学研究所研究会
  • Place of Presentation: 岡崎
  • Year and Date: 20060300
• [Presentation] Pharmacological control of visual cortical plasticity (2006)
  • Author(s): Hensch, T.K.
  • Organizer: 岡山大学医学部眼科学教室セミナー
  • Place of Presentation: 岡山
  • Year and Date: 20060100
• [Presentation] Critical period plasticity in local cortical circuits (2006)
  • Author(s): Hensch, T.K.
  • Organizer: 基生研セミナー
  • Place of Presentation: 岡崎
  • Year and Date: 20060100
• [Presentation] 大脳視覚野の臨界期:分子と神経回路機能の統合的研究 (2005)
  • Author(s): Hensch, T.K.
  • Organizer: 平成17年度文部科学省特定領域研究「統合脳」冬のシンポジウム「公開シンポジウム」
  • Place of Presentation: 東京
  • Year and Date: 20051200
• [Presentation] Critical period specification by Otx2 transfer into visual cortex (2005)
  • Author(s): Hensch, T.K.
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 20051200
• [Presentation] 視覚の発達「臨界期」 (2005)
  • Author(s): Hensch, T.K.
  • Organizer: 第46回日本視能矯正学会, (日本視能訓練士協会)
  • Place of Presentation: 大阪
  • Year and Date: 20051100
• [Presentation] Pharmacological control of brain development (2005)
  • Author(s): Hensch, T.K.
  • Organizer: 第28回日本神経科学大会(Neuroscience 2005)
  • Place of Presentation: 横浜
  • Year and Date: 20050700
• [Patent(Industrial Property Rights)] EPIGENETICAL EGULATION OF BRAIN PLASTICITY (2007)
  • Inventor(s): SNG, Judy, HENSCH, Takao, FAGIOLINI, Michela, CARNINCI, Piero, LENNARTSSON, Andreas
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Industrial Property Number: 特許
  • Filing Date: 2007-04-09