2009 Fiscal Year Final Research Report
Computational understanding of the cortico-basal ganglia interplay through dynamical network behavior
| Project/Area Number |
17022036
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUKAI Tomoki The Institute of Physical and Chemical Research, 脳回路機能理論研究チーム, チームリーダー (40218871)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 神経回路モデル / 意思決定 / 完全時間積分 / シナプス可塑性モデル / 興奮と抑制のバランス / マッチング行動 / 多細胞記録 |
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| Research Abstract |
We proposed theories to reveal how cortical neurons and networks receiving balanced synaptic input represent or transmit information. Perfect temporal integration of correlated spike input was proposed for a network mechanism of decision making. We formulated the basal ganglia mechanism of reward-driven decision making and clarified the information theoretic basis of matching behavior. We experimentally and theoretically revealed the essential role of inhibitory circuit plasticity in ocular dominance column formation. We proposed an accurate spike sorting method for multiunit recordings and provided it with an open software package.
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