2009 Fiscal Year Final Research Report
Functional connectivity and relationship among reward-related and reward expectancy-related brain areas in goal-directed behavior
| Project/Area Number |
17022050
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
WATANABE Masataka Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 特任研究員 (50092383)
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| Co-Investigator(Kenkyū-buntansha) |
KODAMA Tohru 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 (20195746)
HIKOSAKA Kazuo 川崎医療福祉大学, 医療技術学部, 教授 (60129004)
HONNDA Yoshiko 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (50142154)
KOJIMA Takashi 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (30225429)
KUWAHATA Taku 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (70415537)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAGAMI Masamichi 玉川大学, 脳科学研究所, 教授
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| Project Period (FY) |
2005 – 2009
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| Keywords | 報酬 / 報酬期待 / 動機づけ / ニューロン活動 / ドーパミン |
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| Research Abstract |
For survival and reproduction, organisms work to obtain rewards (food, liquid or mates). For humans, beautiful or interesting objects are also rewarding. This study was conducted to clarify what brain areas are responsible for detecting/expecting the reward, and how these reward-related areas interact. It was found that (1)the prefrontal cortex is involved in integrating cognitive and motivational information ; and (2)dopamine in the prefrontal cortex and striatum plays important roles in goal-directed behavior.
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[Journal Article] Default mode of brain activity demonstrated by PET imaging in awake monkeys -higher rest-related than working memory-related activity in medial cortical areas.2009
Author(s)
Kojima, T., Onoe, H., Hikosaka, K., Tsutui, K-I., Tsukada, H., Watanabe, M.
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Journal Title
J. Neurosci. 29
Pages: 14463-14471
Peer Reviewed
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[Journal Article] Domain-related differentiation of working memory in the Japanese macaque (Macaca fuscata) frontal cortex: a positron emission tomography study.2007
Author(s)
Kojima, T., Onoe, H., Hikosaka, K, Tsutsui, K, Tsukada, H, Watanabe, M.
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Journal Title
Eur. J. Neurosci. 25
Pages: 2523-2535
Peer Reviewed
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[Journal Article] Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex.2006
Author(s)
Kobayashi, S., Nomoto, K., Watanabe, M., Hikosaka, O., Schultz, W., Sakagami, M.
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Journal Title
Peer Reviewed
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[Presentation] Regions showing task-induced deactivation and regions with the highest level of regional cerebral blood flow during rest - A monkey PET study2009
Author(s)
Kojima, T., Onoe, H., Hikosaka, K., Tsutui, K-I., Tsukada, H., Watanabe, M.
Organizer
39th Society for Neuroscience Meeting
Place of Presentation
McCormic Convention Center, Chicago, USA
Year and Date
2009-10-21
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