Brain information processing mechanism on goal-directed behavior based on motivation

2009 Fiscal Year Final Research Report

• Project/Area Number: 17022052
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Tsukuba
• Principal Investigator: SHIDARA Munetaka University of Tsukuba, 大学院・人間総合科学研究科, 教授 (10357189)
• Project Period (FY): 2005 – 2009
• Keywords: 報酬期待 / 報酬価値 / 単一ニューロン記録 / 前部帯状皮質 / 背側縫線核 / 前部島皮質 / セロトニンニューロン / 行動決定

Research Abstract

Neuronal activities were investigated while monkeys performed the multi-trial reward schedule task with variable reward amount. In rostral part of anterior cingulate cortex neurons responded at the first trial of the schedule, then gradually decreased through schedule progress. In anterior insular cortex neurons responded when there was possibility to obtain reward. In dorsal raphe nucleus there were neurons that responded in non-rewarded trials. In decision-making task monkey's choice behavior could be explained by exponential discounting model of reward value.

Research Products

• [Journal Article] A comparison of reward-contingent neuronal activity in monkey orbitofrontal cortex and ventral striatum: guiding actions toward rewards. (2007)
  • Author(s): Simmons, JM., Ravel, S., Shidara, M. Richmond, BJ.
  • Journal Title: Ann N Y Acad Sci. 1121 Pages: 376-94
  • Peer Reviewed
• [Journal Article] Mode changes in activity of single neurons in anterior insular cortex across trials during multi-trial reward schedules. (2007)
  • Author(s): Mizuhiki, T., Richmond, BJ., Shidara M.
  • Journal Title: Neurosci Res. 57 Pages: 587-91
  • Peer Reviewed
• [Journal Article] Neuronal firing in anterior cingulate neurons changes modes across trials in single states of multitrial reward schedules. (2005)
  • Author(s): Shidara, M., Mizuhiki, T., Richmond BJ.
  • Journal Title: Exp Brain Res. 163 Pages: 242-5
  • Peer Reviewed
• [Presentation] Effects of the reward proximity and amount on neuronal signals in rostral part of monkey anterior cingulate cortex. (2009)
  • Author(s): Toda K., Mizuhiki T., Sugae-Miyamoto Y., Inaba K., Richmond BJ., Shidara M
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA.
  • Year and Date: 20091017-20091021
• [Presentation] Single neuronal responses in monkey dorsal raphe nucleus during multi-trial reward schedule task with different reward amount. (2009)
  • Author(s): Inaba K., Mizuhiki T., Toda K., Ozaki S., Yaguchi K., Shidara M
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 20091017-20091021
• [Presentation] The behavioral response of the monkey during a decision-making task to chose reward schedule and amount. (2009)
  • Author(s): Mizuhiki T., Inaba K., Yaguchi K., Shidara M.
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA.
  • Year and Date: 20091017-20091021
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/basic-med/physiology/sys-neurosci/