Structural and molecular bases for development and maturation of competitive synaptic wiring

2009 Fiscal Year Final Research Report

• Project/Area Number: 17023001
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hokkaido University
• Principal Investigator: WATANABE Masahiko Hokkaido University, 大学院・医学研究科, 教授 (70210945)
• Project Period (FY): 2005 – 2009
• Keywords: 小脳 / シナプス / グルタミン酸 / 発達 / 遺伝子改変動物

Research Abstract

An enormous number of homotypic and heterotypic inputs innervate given neurons, and establish functional neural circuits through their competition. In this study, I undertook cellular and molecular mechanisms underlying the competitive circuit development in the cerebellum, a center of motor learning and coordination. I have identified that glutamate receptor GluD2 on Purkinje cells and Cbln1 released from granule cells coordinately regulate the formation and maintenance of parallel fiber synapses, and the establishment and maintenance of climbing fiber mono-innervation.

Research Products

• [Journal Article] Endocannabinoids and CB1 receptors mediate C-fiber-dependent heterosynaptic plasticity in spinalcord. (2009)
  • Author(s): Pernia-Andrade AJ, Kato A, Witschi R, Nyilas R, Katona I, Freund TF, Watanabe M, Filitz J, Koppert W, Schuttler J, Guangchen J, Neugebauer V, Marcasino G, Lutz B, Vanegas H, Zeilhofer HU
  • Journal Title: Science 325 Pages: 760-764
  • Peer Reviewed
• [Journal Article] NMDA receptor GluN2B (GluRe2/NR2B) subunit Is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. (2009)
  • Author(s): Akashi K, Kakizaki T, Kamiya H, Fukaya M, Yamasaki M, Abe M, Natsume R, Watanabe M, Sakimura K
  • Journal Title: J. Neurosci 29 Pages: 10869-10882
  • Peer Reviewed
• [Journal Article] Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord. (2009)
  • Author(s): Yasaka T, Hughes DI, Polgar E, Nagy GG, Watanabe M, Riddell JS, Todd AJ
  • Journal Title: J. Neurosci 29 Pages: 13401-13409
  • Peer Reviewed
• [Journal Article] Rescue of abnormal phenotypes in d2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the d2 glutamate receptor. (2009)
  • Author(s): Torashima T, Iizuka1 A, Horiuchi H, Mitsumura K, Yamasaki M, KoyamaC, Takayama K, Iino M, Watanabe M, Hirai H
  • Journal Title: Eur J Neurosci 30 Pages: 355-365
  • Peer Reviewed
• [Journal Article] Functional coupling between mGluR1 and Cav3. 1 T-type calcium channels underlies parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. (2009)
  • Author(s): Hildebr, ME, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, Schneider T, Hescheler J, Kano M, Sakimura K, Watanabe M, Dieudonne S, Snutch TP
  • Journal Title: J. Neurosci 29 Pages: 9668-9682
  • Peer Reviewed
• [Journal Article] Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum. (2009)
  • Author(s): Hashimoto K, Ichikawa R, Kitamura K, Watanabe M, Kano M
  • Journal Title: Neuron 63 Pages: 106-118
  • Peer Reviewed
• [Journal Article] The N-terminal domain of GluRδ2 recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo. (2009)
  • Author(s): Kakegawa W, Miyazaki T, Kohda K, Matsuda K, Emi K, Motohashi J, Watanabe M, Yuzaki M
  • Journal Title: J. Neurosci 29 Pages: 5738-5748
  • Peer Reviewed
• [Journal Article] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum. (2009)
  • Author(s): Matsuda K, Kondo T, Iijima T, Matsuda S, Watanabe M, Yuzaki M
  • Journal Title: Eur J Neurosci 29 Pages: 707-717
  • Peer Reviewed
• [Journal Article] PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. (2009)
  • Author(s): Zhang J, Xu T, Hallett PJ, Watanabe M, Grant SGN, Isacson O, Yao W-D
  • Journal Title: J. Neurosci 29 Pages: 2948-2960
  • Peer Reviewed
• [Journal Article] Cbln1 accumulates and colocalizes with Cbln3 and GluRd2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum. (2009)
  • Author(s): Miura E, Matsuda K, Morgan JI, Yuzaki M, Watanabe M
  • Journal Title: Eur J Neurosci 29 Pages: 693-706
  • Peer Reviewed
• [Journal Article] Left-right asymmetry of the hippocampal synapses with different subunit allocation of glutamate receptors. (2008)
  • Author(s): Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 19498-19503
  • Peer Reviewed
• [Journal Article] Phospholipase Cb3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. (2008)
  • Author(s): Shi TJ, Liu SX, Hammarberg H, Watanabe M, Xu ZQ, Hokfelt T
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 20004-20008
  • Peer Reviewed
• [Journal Article] Predominant expression of phospholipase Cb1 in telencephalic principal neurons and cerebellar interneurons, and its close allocation with related signaling molecules in somatodendritic neuronal elements. (2008)
  • Author(s): Fukaya M, Uchigashima M, Nomura S, Hasegawa Y, Kikuchi H, Watanabe M
  • Journal Title: Eur J Neurosci 28 Pages: 1744-1759
  • Peer Reviewed
• [Journal Article] Use-dependent amplification of presynaptic Ca2+ signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse. (2008)
  • Author(s): Shimizu H, Fukaya M, Yamasaki M, Watanabe M, Manabe T, Kamiya H
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 11998-12003
  • Peer Reviewed
• [Journal Article] Spinocerebellar ataxia type 6 knock-in mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Cav2. 1 channels. (2008)
  • Author(s): Watase K, Barrett CF, Miyazaki T, Ishiguro T, Ishikawa K, Hu Y, Unno T, Sun Y, Kasai S, Watanabe M, Gomez CM, Mizusawa H, Tsien RW, Zoghbi HY
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 11987-11992
  • Peer Reviewed
• [Journal Article] Enhanced cerebellar LTD induction and OKR adaptation in mice lacking delphilin. (2008)
  • Author(s): Takeuchi, T., Ohtsuki, G., Yoshida, T., Fukaya, M., Wainai, T., Yamashita M, Yamazaki Y, Mori, M., Sakimura, K., Kawamoto, S., Watanabe, M., Hirano, T., Mishina, M.
  • Journal Title: PLoS One 3(5)(on-line journal) Pages: e2297
  • Peer Reviewed
• [Journal Article] Cbln1 Regulates Rapid Formation and Maintenance of Excitatory Synapses in Mature Cerebellar Purkinje Cells in vitro and in vivo. (2008)
  • Author(s): Ito-Ishida A, Miura E, Emi K, Matsuda K, Iijima K, Narumi S, Kondo T, Kohda K, Watanabe M, Yuzaki M
  • Journal Title: J. Neurosci 28 Pages: 5920-5930
  • Peer Reviewed
• [Journal Article] Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors. (2008)
  • Author(s): Patrizi A, Scelfo B, Viltono L, Briatore F, Fukaya M, Watanabe M, Strata P, Varoqueaux F, Brose N, Fritschy JM, Sassoe-Pognetto M
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 13151-13156
  • Peer Reviewed
• [Journal Article] Dual coupling of T-type Ca2+ channels shapes sleep-related oscillations in thalamic dendrites. (2008)
  • Author(s): Cueni L, Canepari M, Lujan R, Watanabe M, Bond CT, Adelman JP, Luthi A
  • Journal Title: Nature Neurosci 11 Pages: 683-692
  • Peer Reviewed
• [Journal Article] Glutamate transporters regulate lesion-induced period plasticity in the developing somatosensory cortex. (2008)
  • Author(s): Takasaki C, Okada R, Mitani A, Fukaya M, Yamasaki M, Fujihara Y, ShirakawaT, Tanaka K, Watanabe M
  • Journal Title: J. Neurosci 28 Pages: 4995-5006
  • Peer Reviewed
• [Journal Article] Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP4. (2008)
  • Author(s): Matsuda S, Miura E, Matsuda K, Kakegawa W, Kohda K, Watanabe M, Yuzaki M
  • Journal Title: Neuron 57 Pages: 730-745
  • Peer Reviewed
• [Journal Article] SK2 channel plasticity contributes to LTP at Shaffer collateral-CA1 synapses. (2008)
  • Author(s): Lin MT, Lujan R, Watanabe M, Adelman JP, Maylie J
  • Journal Title: Nature Neurosci. 11 Pages: 170-177
  • Peer Reviewed
• [Journal Article] Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals. (2008)
  • Author(s): Nyilas R, Dudok B, Urban GM, Mackie K, Watanabe M, Cravatt BF, Freund TF, Katona I
  • Journal Title: J Neurosci 28 Pages: 1058-1063
  • Peer Reviewed
• [Journal Article] Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. (2008)
  • Author(s): Ludanyi A, Erass L, Czirjak S, Vajda J, Halasz P, Watanabe M, Palkovits M, Magloczky Z, Freund TF, Katona I
  • Journal Title: J Neurosci 28 Pages: 2976-2990
  • Peer Reviewed
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRd2 (2008)
  • Author(s): Kakegawa W, Miyazaki T, Emi K, Matsuda K, Kohda K, Motohashi J, Mishina M, Kawahara S, Watanabe M, Yuzaki M
  • Journal Title: J Neurosci 28 Pages: 1460-0468
  • Peer Reviewed
• [Journal Article] RGS2 modulates GABAB receptor-GIRK channel coupling in dopamine neurons of the ventral tegmental area. (2007)
  • Author(s): Labouebe G, Lomazzi M, Cruz HG, Lujan R, Li M, Yanagawa Y., Obata K., Watanabe M, Wickman K, Slesinger P, Luscher C
  • Journal Title: Nature Neurosci 10 Pages: 1559-1568
  • Peer Reviewed
• [Journal Article] Regulation of long-term depression and climbing fiber territory by GluRd2 at parallel fiber synapses through its cariboxyl terminal domain in cerebellar Purkinje cells. (2007)
  • Author(s): Uemura T, Kakizawa T, Yamasaki M, Sakimura K, Watanabe M, Iino M, Mishina M
  • Journal Title: J Neurosci 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum. (2007)
  • Author(s): Nishiyama H, Fukaya M, Watanabe M, Linden D
  • Journal Title: Neuron 56 Pages: 472-487
  • Peer Reviewed
• [Journal Article] Involvement of nitric ocide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells. (2007)
  • Author(s): Makara JK, Katona I, Nyiri G, Nemeth B, Watanabe M, Vente J de, Freund TF, Hajos N
  • Journal Title: J. Neurosci 27 Pages: 10211-10222
  • Peer Reviewed
• [Journal Article] Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus. (2007)
  • Author(s): Uchigashima M, Fukaya M, Watanabe M, Kamiya H
  • Journal Title: J. Neurosci 27 Pages: 8088-8100
  • Peer Reviewed
• [Journal Article] Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. (2007)
  • Author(s): Uchigashima M, Narushima M, Fukaya M, Katona I, Kano M, Watanabe M
  • Journal Title: J. Neurosci. 27 Pages: 3663-3676
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Kakizawa, S. Kishimoto, Y., Hashimoto, K., Miyazaki, T. Furutani, K., Shimizu H, Fukaya M, Nishi, M., Sakagami, H., Ikeda A, Kondo, H., Kano, M., Watanabe, M., Iino, M., Takeshima, H.
  • Journal Title: EMBO J. 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Ca2+ permeability of the channel pore is not essential for the d2 glutamate receptor to regulate synaptic plasticity and motor coordination. (2007)
  • Author(s): Kakegawa W, Miyazaki T., Hirai H, Motohashi J, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: J. Physiol. 579 Pages: 729-735
  • Peer Reviewed
• [Journal Article] Characterization of a transneuronal cytokine family Cbln. regulation of secretion by heteromeric assembly. (2007)
  • Author(s): Iijima T, Miura E, Matsuda K, Kondo T, Kamekawa Y, Watanabe M, Yuzaki M
  • Journal Title: Eur. J. Neurosci. 25 Pages: 1049-1057
  • Peer Reviewed
• [Journal Article] Phospholipase Cb is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets. (2007)
  • Author(s): Nomura S, Fukaya M, Tsujioka T, Wu D, Watanabe M
  • Journal Title: Eur. J. Neurosci 25 Pages: 659-672
  • Peer Reviewed
• [Journal Article] Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. (2007)
  • Author(s): Narushima M, Uchigashima M, Matsui M, Manabe T, Watanabe M, Kano M
  • Journal Title: J. Neurosci. 27 Pages: 496-506
  • Peer Reviewed
• [Journal Article] Indispensability of glutamate transporter GLAST and GLT1 to brain development. (2006)
  • Author(s): Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo K, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 12161-12166
  • Peer Reviewed
• [Journal Article] Abundant distribution of TARP g-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. (2006)
  • Author(s): Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K
  • Journal Title: Eur. J. Neurosci 24 Pages: 2177-2190
  • Peer Reviewed
• [Journal Article] Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. (2006)
  • Author(s): Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito S, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 10811-10816
  • Peer Reviewed
• [Journal Article] Distinct expression of Cbln family mRNAs in developing and adult mouse brains. (2006)
  • Author(s): Miura E, Iijima T, Yuzaki M, Watanabe M
  • Journal Title: Eur. J. Neurosci. 24 Pages: 750-760
  • Peer Reviewed
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (2006)
  • Author(s): Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T
  • Journal Title: EMBO J. 25 Pages: 2867-2877
  • Peer Reviewed
• [Journal Article] Localization of diacylglycerol lipase-a round postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. (2006)
  • Author(s): Yoshida T, Fukaya M, Uchigashima M, Kamiya H, Kano M, Watanabe M
  • Journal Title: J. Neurosci. 26 Pages: 4740-4751
  • Peer Reviewed
• [Journal Article] Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. (2006)
  • Author(s): Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M
  • Journal Title: J. Neurochem. 97 Pages: 1431-1446
  • Peer Reviewed
• [Journal Article] CB1 is the major cannabinoid receptor at excitatory presynaptic site in the hippocampus and cerebellum. (2006)
  • Author(s): Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M
  • Journal Title: J. Neurosci. 26 Pages: 2991-3001
  • Peer Reviewed
• [Journal Article] Impaired cerebellar functions in mutant mice lacking DNER. (2006)
  • Author(s): Tohgo A, Eiraku M, Miyazaki T, Miura E, Ono K, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H
  • Journal Title: Mol. Cell. Neurosci. 31 Pages: 326-333
  • Peer Reviewed
• [Journal Article] Complementary stripes of phospholipase Cs3 and Cs4 expression by Purkinje cell subsets in the mouse cerebellum. (2006)
  • Author(s): Sarna JT, Marzban H, Watanabe M, Hawkes R
  • Journal Title: J. Comp. Neurol. 496 Pages: 303-313
  • Peer Reviewed
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa S, Miyazaki T, Iino M, Watanabe M, Kano M
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 19180-19185
  • Peer Reviewed
• [Journal Article] Clbn1 is essential for synaptic integrity and information processing in the cerebellum. (2005)
  • Author(s): Hirai H, Pang Z, Bao D, Miyazaki T, Li L, Miura E, Parris J, Rong Y, Watanabe M, Yuzaki M, Morgan JI
  • Journal Title: Nature Neurosci. 8 Pages: 1534-1541
  • Peer Reviewed
• [Journal Article] Complementary roles of cholecystokinin and parvalbumin expressing GABAergic neurons in hippocampal network oscillations. (2005)
  • Author(s): Klausberger T, Marton LF, O'Neill J, Huck JHJ, Dalezios Y, Fuentealba P, Suen W-Y, Papp E, Kaneko T, Watanabe M, Csicsvari J, Somogyi P
  • Journal Title: J. Neurosci. 25 Pages: 9782-9793
  • Peer Reviewed
• [Journal Article] Spatial diversity in gene expression for VDCCg subunit family in developing and adult mouse brains. (2005)
  • Author(s): Fukaya M, Yamazaki M, Sakimura K, Watanabe M
  • Journal Title: Neurosci. Res. 53 Pages: 376-383
  • Peer Reviewed
• [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in e1 knock-out mice. (2005)
  • Author(s): Wu Y, Kawakami R, Fukaya M, Sakimura K, Mishina M, Watanabe M, Ito I, Shigemoto R
  • Journal Title: J. Neurosci. 25 Pages: 9213-9226
  • Peer Reviewed
• [Journal Article] Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
  • Author(s): Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CVE, Kawaguchi Y, Nakao K, Nabeshima Y
  • Journal Title: Neuron 47 Pages: 201-213
  • Peer Reviewed
• [Journal Article] Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. (2005)
  • Author(s): Takayasu Y, Iino M, Kakegawa W, Maeno H, Watase K, Wada K, Miyazaki T, Watanabe M, Tanaka K, Ozawa
  • Journal Title: J. Neurosci. 25 Pages: 8788-8793
  • Peer Reviewed
• [Journal Article] Control of synaptic connection by glutamate receptor d2 n the mature cerebellum. (2005)
  • Author(s): Takeuchi T, Miyazaki T, Watanabe M, Mori H, Sakimura K, Mishina M
  • Journal Title: J. Neurosci. 25 Pages: 2146-2156
  • Peer Reviewed
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya M, Hayashi Y, Watanabe M
  • Journal Title: Eur. J. Neurosci. 21 Pages: 1432-1436
  • Peer Reviewed
• [Journal Article] Rescue of abnbormal phenotypes of the d glutamate receptor-null mice by mutant d transgenes. (2005)
  • Author(s): Hirai H, Miyazaki T, Kakegawa W, Matsuda S, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: EMBO Rep 6 Pages: 90-95
  • Peer Reviewed
• [Journal Article] Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission.
  • Author(s): Yamasaki M, Matsui M, Watanabe M
  • Journal Title: J. Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Cbln1 is a ligand for an orphan glutamate receptor d2, a bidirectional synaptic organizer.
  • Author(s): Matsuda K, Miura E, Miyazaki T, Kakegawa W, Emi K, Narumi S, Fukazawa Y, Itoh-Ishida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M
  • Journal Title: Science (in press)
  • Peer Reviewed
• [Presentation] Coordinated molecular organization of 2-arachidonoyl glycerol-mediated endocannabinoid signaling triggered by mGluR activation. (2008)
  • Author(s): Watanabe M
  • Organizer: 6th International Meeting on Metabotropic Glutamate Receptors
  • Place of Presentation: Sicily (Italy)
  • Year and Date: 20080914-20080919
• [Presentation] Glutamate transporters provide a 'winner-takes-more' strategy to activity-dependent synapse refinement. (2008)
  • Author(s): Watanabe, M
  • Organizer: The 38th Seiriken/Soukendai International Conference (Stock and flow of functional molecules in synapses.
  • Place of Presentation: Okazaki (Japan)
  • Year and Date: 20080317-20080319
• [Book] みる見るわかる脳・神経科学入門講座改訂版 (2008)
  • Author(s): 渡辺雅彦
  • Publisher: 羊土社
• [Book] 脳神経外科学大系1。神経科学, (山浦晶総編集) (2006)
  • Author(s): 渡辺雅彦
  • Total Pages: 50-67
  • Publisher: 中山書店
• [Book] 組織細胞化学2005, (日本組織細胞化学会編) (2005)
  • Author(s): 渡辺雅彦
  • Total Pages: 23-36
  • Publisher: 学際企画
• [Remarks]
  • URL: http://www.med.hokudai.ac.jp/~anat-2w/