2009 Fiscal Year Final Research Report
Analysis of tectal layer formation and mechanisms of retinotectal projection.
| Project/Area Number |
17023003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAMURA Harukazu Tohoku University, 大学院・生命科学研究科, 教授 (90079690)
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| Co-Investigator(Kenkyū-buntansha) |
FUNAHASHI Jun-Ichi 東北大学, 加齢医学研究所, 准教授 (00270827)
WATANABE Yuji 東北大学, 大学院・生命科学研究科, 助教 (80301042)
OMI Minoru 東北大学, 大学院・生命科学研究科, 助教 (00400416)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ニワトリ胚 / 網膜視蓋投射 / 視蓋 / EphrinA2 / EphrinA5 / Fgf8 / En2 / エレクトロポレーション |
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| Research Abstract |
In lower vertebrates, optic tectum is the visual center and receives retinal fibers in a retinotopic manner. We have shown that Ephrin A2 and A5, which are expressed in the posterior tectum and repel temporal retinal fibers, are induced by Fgf8, but that signal transduction to induce Ephrin A2 and A5 are different. We have elaborated new fiber tracing method, and unraveled new but transient retinotectal pathway which invade deeper layer of the tectum from the first.
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[Presentation] Establishment of anteroposterior axis of the chick optic tectum by Fgf-Ras-ERK signaling.2007
Author(s)
Harada, H., Matsuda, Y., Tanaka, J., Suzuki-Hirano, A., Nakamura, H.
Organizer
International Chick Meeting
Place of Presentation
Barcelona, Spain.
Year and Date
20070411-20070414
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