Functional map in the olfactory cortex of the brain

2009 Fiscal Year Final Research Report

• Project/Area Number: 17023012
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: MORI Kensaku The University of Tokyo, 大学院・医学系研究科, 教授 (60008563)
• Co-Investigator(Renkei-kenkyūsha): NAGAO Hiroshi 東京大学, 大学院・医学系研究科, 助教 (50281647) ; KASHIWADANI Hideki 東京大学, 大学院・医学系研究科, 助教 (70328376)
• Project Period (FY): 2005 – 2009
• Keywords: 嗅覚 / におい情報 / 嗅球 / 嗅皮質

Research Abstract

Our results showed (1)odorant category profile selectivity of olfactory cortex neurons, (2)functional compartmentalization in the odor map of olfactory bulb, (3)state-dependent sensory gating in olfactory cortex, (4)behavioral state regulation of dendrodendritic synapses in olfactory bulb, (5)compensatory rapid switching of binasal inputs in olfactory cortex, and (6)functional differentiation of mitral cell and tufted cell pathways.

Research Products

• [Journal Article] Spatial arrangement of glomerular molecular-feature clusters in the odorant-receptor-class domains of the mouse olfactory bulb J (2010)
  • Author(s): Matsumoto, H., Kobayakawa, K., Kobayakawa, R., Tashiro T., Mori, K., Sakano, H., Mori, K.
  • Journal Title: Neurophysiol.
  • Peer Reviewed
• [Journal Article] Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains (2010)
  • Author(s): Imayoshi, I., Sakamoto M., Yamaguchi, M., Mori, K., Kageyama, R.
  • Journal Title: J. Neurosci. 30(9) Pages: 3489-3498
  • Peer Reviewed
• [Journal Article] Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice (2010)
  • Author(s): Matsuda, I., Fukaya, M., Nakao, H., Nakao, K., Matsumoto, H., Mori, K., Watanabe, M., Aiba, A.
  • Journal Title: Neurosci Res. 66(3) Pages: 321-329.5
  • Peer Reviewed
• [Journal Article] Behavioral state-dependent changes in the information processing mode in the olfactory system Communicative and Integrative Biology (2009)
  • Author(s): Tsuno Y., Mori K.
  • Journal Title: 2 Pages: 362-364
  • Peer Reviewed
• [Journal Article] Perisomatic-targeting granule cells in the mouse olfactory bulb J Comp Neurol (2009)
  • Author(s): Naritsuka H, Sakai K, Hashikawa T, Mori K., Yamaguchi, M.
  • Journal Title: 515 Pages: 409-426
  • Peer Reviewed
• [Journal Article] Olfactory Bulb Mapping Encyclopedia of Neuroscience ln: Squire LR (ed. ), volume 7 (2009)
  • Author(s): Mori K.
  • Journal Title: Oxford: Academic Press 7 Pages: 71-75
  • Peer Reviewed
• [Journal Article] Odor-Induced Persistent Discharge of Mitral Cells in the Mouse Olfactory Bulb J Neurophysiol (2009)
  • Author(s): Matsumoto H, Kashiwadani H, Nagao H, Aiba A, Mori K.
  • Journal Title: 101 Pages: 1890-1900
  • Peer Reviewed
• [Journal Article] Dendrodendritic synapses and functional compartmentalization in the olfactory bulb (2009)
  • Author(s): Mori, K., Matsumoto, H., Tsuno, Y., Igarashi, K.M.
  • Journal Title: Annals of the New York Academy of Sciences 1170 Pages: 255-258
  • Peer Reviewed
• [Journal Article] Compensatory Rapid Switching of Binasal Inputs in the Olfactory Cortex (2008)
  • Author(s): Kikuta S, Kashiwadani H, Mori K
  • Journal Title: J. Neurosci. 28 Pages: 11989-11997
  • Peer Reviewed
• [Journal Article] Behavioral state regulation of dendrodendritic synaptic inhibition in the olfactory bulb (2008)
  • Author(s): Tsuno, Y., Kashiwadani, H., Mori, K.
  • Journal Title: J. Neurosci. 28 Pages: 9227-9238
  • Peer Reviewed
• [Journal Article] Long-term labeling and ablation reveal requirement of continuous neurogenesis for the structural and functional integrity of the adult forebrain (2008)
  • Author(s): Imayoshi, I., Sakamoto, M., Ohtsuka T., Takao, K., Miyakawa, T., Yamaguchi, Y., Mori, K., Ikeda, T., Itohara, S., Kageyama, R.
  • Journal Title: Nature Neuroscience 11 Pages: 1153-1161
  • Peer Reviewed
• [Journal Article] A metric for odorant comparison (2008)
  • Author(s): Haddad, R., Khan, R., Takahashi, Y.K., Mori, K., Harel, D., Sobel, N.
  • Journal Title: Nature Methods 5 Pages: 425-429
  • Peer Reviewed
• [Journal Article] Innate versus learned odor processing in the mouse olfactory bulb (2007)
  • Author(s): Kobayakawa, K., Kobayakawa, R., Matsumoto, H., Oka, Y., Imai, T., Ikawa, M., Okabe, M., Ikeda, T., Itohara, S., Kikusui, T., Mori, K., Sakano, H.
  • Journal Title: Nature 450 Pages: 503-508
  • Peer Reviewed
• [Journal Article] Odorant category profile selectivity of olfactory cortex neurons (2007)
  • Author(s): Yoshida, I., Mori, K.
  • Journal Title: J. Neuroscience 27(34) Pages: 9105-9114
  • Peer Reviewed
• [Journal Article] Interaction between telencephalin and ERM proteins mediates dendritic filopodia formation (2007)
  • Author(s): Furutani, Y., Matsuno, H., Kawasaki, M., Sasaki, T., Mori, K., Yoshihara, Y.
  • Journal Title: J. Neuroscience 27(33) Pages: 8866-8876
  • Peer Reviewed
• [Journal Article] Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. (2007)
  • Author(s): Hasegawa, S., Yamaguchi, M., Nagao, H, Mishina, M., Mori, K.
  • Journal Title: J. Neuroimmunol. 186 Pages: 75-85
  • Peer Reviewed
• [Journal Article] A transcription enhancer that directs telencephalon-specific transgene expression in mouse brain (2007)
  • Author(s): Mitsui, S., Saito, M., Mori, K., Yoshihara, Y.
  • Journal Title: Cerebral Cortex. 17 Pages: 522-530
  • Peer Reviewed
• [Journal Article] Schnurri-2 mutant mice are hypersensitive to stress and hyperactive (2006)
  • Author(s): Takagi, T., Jin, W. Taya, K., Watanabe, G., Mori, K., Ishii, S.
  • Journal Title: Brain Res. 1108 Pages: 88-97
  • Peer Reviewed
• [Journal Article] Telencephalin slows spine maturation (2006)
  • Author(s): Matsuno, H, Okabe S., Mishina M., Yanagida T., Mori K., Yoshihara, Y.
  • Journal Title: J. Neuroscience 26(6) Pages: 1776-1786
  • Peer Reviewed
• [Journal Article] Maps of odorant molecular features in the mammalian olfactory bulb (2006)
  • Author(s): Mori, K., Takahashi, Y.K., Igarashi, K.M., Yamaguchi, Y.
  • Journal Title: Physiological Reviews. 86(2) Pages: 409-433
  • Peer Reviewed
• [Journal Article] A leucine-rich repeat membrane protein 5T4 is expressed by a subtype of granule cells with dendritic arbor in specific strata of the mouse olfactory bulb (2006)
  • Author(s): Imamura, F., Nagao, H., Naritsuka, H., Murata, Y., Taniguchi, H., Mori K.
  • Journal Title: J. Comp. Neurol. 495 Pages: 754-768
  • Peer Reviewed
• [Journal Article] State-dependent sensory gating in olfactory cortex (2005)
  • Author(s): Murakami, M., Kashiwadani, H., Kirino, Y., Mori, K
  • Journal Title: Neuron 46 Pages: 285-296
  • Peer Reviewed
• [Journal Article] A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites (2005)
  • Author(s): Mitsui, S., Saito, M., Hayashi, K., Mori, K., Yoshihara, Y.
  • Journal Title: J. Neuroscience 25 Pages: 1122-1131
  • Peer Reviewed
• [Journal Article] Critical period for sensory experience-dependent survival of newly-generated granule cells in the adult mouse olfactory bulb (2005)
  • Author(s): Yamaguchi, M., Mori, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 9697-9702
  • Peer Reviewed
• [Journal Article] Spatial representation of hydrocarbon odorants in the ventrolateral zones of the olfactory bulb (2005)
  • Author(s): Igarashi, K.M., Mori, K.
  • Journal Title: J. Neurophysiol. 93 Pages: 1007-1019
  • Peer Reviewed
• [Remarks]
  • URL: http://morilab.m.u-tokyo.ac.jp//