Higher sensory processing mechanisms investigated by transcranial imaging of mouse cortical activities

2009 Fiscal Year Final Research Report

• Project/Area Number: 17023020
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Niigata University
• Principal Investigator: SHIBUKI Katsuei Niigata University, 脳研究所, 教授 (40146163)
• Project Period (FY): 2005 – 2009
• Keywords: フラビン蛋白蛍光 / 経頭蓋イメージング / 体性感覚野 / 視覚野 / 聴覚野 / マウス

Research Abstract

Endogenous green fluorescence signals derived from mitochondria reflect activity-dependent changes in brain metabolism, and may be exploited in functional brain imaging. Endogenous flavoprotein fluorescence imaging in mice is especially important because the transparent skull of mice allows transcranial fluorescence imaging of cortical activities. Using this technique, we investigated cortical activities and experiencedependent plasticity in the somatosensory, visual and auditory cortices of mice.

Research Products

• [Journal Article] Cortical depression in the mouse auditory cortex after sound discrimination learning (2010)
  • Author(s): Ohshima S, Tsukano H, Kubota Y, Takahashi K, Hishida R, Takahashi S, Shibuki K
  • Journal Title: Neurosci Res 67 Pages: 51-58
  • Peer Reviewed
• [Journal Article] Transcranial imaging of somatotopic map plasticity after tail cut in mice (2010)
  • Author(s): Kitaura H, Hishida R, Shibuki K
  • Journal Title: Brain Res 1319 Pages: 54-59
  • Peer Reviewed
• [Journal Article] Activity dependent glial swelling is impaired in aquaporin-4 knockout mice (2009)
  • Author(s): Kitaura H, Tsujita M, Kakita A, Shibuki K, Sakimura K, Kwee KL, Nakada T:
  • Journal Title: Neurosci Res 64 Pages: 208-212
  • Peer Reviewed
• [Journal Article] Transcranial flavoprotein fluorescence imaging of mouse cortical activity and plasticity (2009)
  • Author(s): Tohmi M, Takahashi K, Kubota Y, Hishida R, Shibuki K
  • Journal Title: J Neurochem 109Suppl.1 Pages: 3-9
  • Peer Reviewed
• [Journal Article] Transcranial photo-inactivation of neural activities in the mouse auditory cortex (2008)
  • Author(s): Kubota Y, Kamatani D, Tsukano H, Ohshima S, Takahashi K, Hishida R, Kudoh M, Takahashi S, Shibuki K
  • Journal Title: Neurosci Res 60 Pages: 422-430
  • Peer Reviewed
• [Journal Article] Long-term depression induced by local tetanic stimulation in the rat auditory cortex (2007)
  • Author(s): Watanabe K, Kamatani D, Hishida R, Kudoh M, Shibuki K
  • Journal Title: Brain Res 1166 Pages: 20-28
  • Peer Reviewed
• [Journal Article] Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex (2007)
  • Author(s): Kitaura H, Uozumi N, Tohmi M, Yamazaki M, Sakimura K, Kudoh M, Shimizu T, Shibuki K
  • Journal Title: Neurosci Res 59 Pages: 160-171
  • Peer Reviewed
• [Journal Article] Experience-dependent formation of activity propagation patterns at the somatosensory S1 and S2 boundary in rat cortical slices (2007)
  • Author(s): Kamatani D, Hishida R, Kudoh M, Shibuki K
  • Journal Title: Neuroimage 35 Pages: 47-57
  • Peer Reviewed
• [Journal Article] Functional local connections with differential activity-dependence and critical periods surrounding the primary auditory cortex in rat cerebral slices (2007)
  • Author(s): Hishida R, Kamatani D, Kitaura H, Kudoh M, Shibuki K
  • Journal Title: Neuroimage 34 Pages: 679-693
  • Peer Reviewed
• [Journal Article] Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex (2006)
  • Author(s): Tohmi M, Kitaura H, Komagata S, Kudoh M, Shibuki K
  • Journal Title: J Neurosci 26 Pages: 11775-11785
  • Peer Reviewed
• [Journal Article] Requirement of the auditory association cortex for discrimination of vowel-like sounds in rats (2006)
  • Author(s): Kudoh M, Nakayama Y, Hishida R, Shibuki K
  • Journal Title: Neuroreport 17 Pages: 1761-1766
  • Peer Reviewed
• [Journal Article] Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex (2006)
  • Author(s): Kudoh M, Shibuki K
  • Journal Title: Learn Mem 13 Pages: 690-698
  • Peer Reviewed
• [Journal Article] Roles of the auditory cortex in discrimination learning by rats (2006)
  • Author(s): Ono K, Kudoh M, Shibuki K
  • Journal Title: Eur J Neurosci 23 Pages: 1623-1632
  • Peer Reviewed
• [Journal Article] Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice (2006)
  • Author(s): Takahashi K, Hishida R, Kubota Y, Kudoh M, Takahashi S, Shibuki K
  • Journal Title: Eur J Neurosci 23 Pages: 1265-1276
  • Peer Reviewed
• [Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice (2006)
  • Author(s): Takao T, Murakami H, Fukuda M, Kawaguchi T, Kakita A, Takahashi H, Kudoh M, Tanaka R, Shibuki K
  • Journal Title: Neuroreport 17 Pages: 267-271
  • Peer Reviewed
• [Journal Article] Endogenous fluorescence imaging of somatosensory cortical activities after discrimination learning in rats (2006)
  • Author(s): Shibuki K, Ono K, Hishida R, Kudoh M
  • Journal Title: Neuroimage 30 Pages: 735-744
  • Peer Reviewed
• [Book] Flavoprotein fluorescence imaging of experience-dependent cortical plasticity in rodents(Frostig R ed) (2009)
  • Author(s): Shibuki K, Hishida R, Tohmi M, Takahashi K, Kitaura H, Kubota Y
  • Total Pages: 193-220
  • Publisher: CRC Press
• [Book] Coupling of brain function and metabolism: Endogenous flavoprotein fluorescence imaging of neural activities by local changes in energy metabolism.(Gibson G and Dienel G, ed, Handbook of Neurochemistry & Molecular Neurobiology) (2007)
  • Author(s): Shibuki K, Hishida R, Kitaura H, Takahashi K, Tohmi M
  • Total Pages: 322-342
  • Publisher: Springer
• [Remarks]
  • URL: http://www.bri.niigata-u.ac.jp/~physio/