Experience-dependent remodeling of visual neural circuits.

2009 Fiscal Year Final Research Report

• Project/Area Number: 17023033
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tottori University
• Principal Investigator: HATA Yoshio Tottori University, 大学院・医学系研究科, 教授 (40212146)
• Co-Investigator(Kenkyū-buntansha): ICHISAKA Satoshi 鳥取大学, 医学部, 助教 (50359874) ; SATO Takemasa 鳥取大学, 医学部, 助教 (80346345) ; AKASAKI Takafumi 鳥取大学, 大学院・医学系研究科, 助教 (30335393)
• Project Period (FY): 2005 – 2009
• Keywords: 眼優位可塑性 / 生後発達 / 大脳皮質視覚野 / 臨界期 / ヘッブ則

Research Abstract

In the developing visual cortex, inappropriate neural connections are eliminated in an experience-dependent manner. This study demonstrated that the input axons to the visual cortex are eliminated when cortical cells do not respond to input activities mainly based on presynaptic mechanisms.

Research Products

• [Journal Article] Cortical activity regulates corticothalamic synapses in dorsal lateral geniculate nucleus of rats. (2009)
  • Author(s): Yoshida M, Satoh T, Nakamura KC, Kaneko T, Hata Y
  • Journal Title: Neurosci. Res. 64 Pages: 118-127
• [Journal Article] Experience-driven axon retraction in the pharmacologically inactivated visual cortex does not require synaptic transmission. (2009)
  • Author(s): Watanabe K, Morishima Y, Toigawa M, Hata Y
  • Journal Title: PLoS ONE 4 Pages: e4193
• [Journal Article] Effects of anesthesia on immunohistochemical detection of phosphorylated extracellular signal-regulated kinase in cerebral cortex. (2008)
  • Author(s): Takamura H, Ichisaka S, Watanabe K, Toigawa M, Hata Y
  • Journal Title: J. Neurosci. Meth. 170 Pages: 300-304
• [Journal Article] Monocular deprivation enhances the nuclear signalling of extracellular signal-regulated kinase in the developing visual cortex. (2007)
  • Author(s): Takamura H, Ichisaka S, Hayashi C, Maki H, Hata Y
  • Journal Title: Eur. J. Neurosci. 26 Pages: 2884-2898
• [Journal Article] Neuroprotective effect of transcorneal electrical stimulation on the acute phase of optic nerve injury. (2007)
  • Author(s): Miyake K, Yoshida M, Inoue Y, Hata Y
  • Journal Title: Invest. Ophthal. Vis. Sci. 48 Pages: 2356-2361
• [Journal Article] Experience-driven axon retraction without binocular imbalance in developing visual cortex. (2007)
  • Author(s): Haruta M, Hata Y
  • Journal Title: Curr. Biol. 17 Pages: 37-42
• [Journal Article] Recovery of binocular responses after brief monocular deprivation in kittens. (2005)
  • Author(s): Kameyama K, Hata Y, Tsumoto T
  • Journal Title: Neuroreport 16 Pages: 1447-1450
• [Presentation] 発達脳の可塑性とその臨界期-視覚系をモデルとして- (2010)
  • Author(s): 畠義郎
  • Organizer: 第51回日本小児神経学会総会
  • Place of Presentation: 米子
  • Year and Date: 2010-05-28
• [Presentation] 視覚経験による視覚中枢神経回路の再編成 (2010)
  • Author(s): 畠義郎
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-16
• [Presentation] Experience-driven axon reorganization in the visual system (2009)
  • Author(s): Yoshio Hata
  • Organizer: 第32回日本神経科学大会Symposium「中枢神経系のマップ形成とその再編成」
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Experience-driven retraction of geniculocortical axons following cortical inactivation by preventing synaptic transmission (2009)
  • Author(s): Kana Watanabe, Yu Morishima, Masahito Toigawa, Yoshio Hata
  • Organizer: 第36回国際生理学会世界大会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] 視覚経験によって引き起こされる視床皮質投射軸索の退縮 (2008)
  • Author(s): 畠義郎
  • Organizer: 第31回日本神経科学大会Workshop「神経活動依存的な回路網形成の制御機構-プレかポストかどっちが大事」
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 自由行動下ラットの外側膝状体ニューロンの持続活動への視覚環境の効果 (2008)
  • Author(s): 田金裕一郎, 赤崎孝文, 久保悠介, 畠義 郎
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] Activity-dependent regulation of mGluR1a and VGluT1 in the lateral geniculate nucleus of rat. (2007)
  • Author(s): Yoshida, M., Satoh, T., Nakamura, K., Kaneko, T., Hata, Y.
  • Organizer: 37th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2007-11-03
• [Presentation] Regulation of nuclear extracellular signal-regulated kinase activity in developing visual cortex. (2007)
  • Author(s): Takamura, H., Ichisaka, S., Hayashi, C., Maki, H., Hata, Y.
  • Organizer: 37th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2007-11-03
• [Presentation] 外側膝状体における代謝型グルタミン酸受容体の活動依存的調節の年齢依存性 (2007)
  • Author(s): 吉田三穂, 佐藤武正, 中村公一, 金子武嗣, 畠義郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] ラット視覚野におけるERK活性とその細胞内局在の視覚入力依存的制御 (2007)
  • Author(s): 高村明孝, 一坂吏志, 林千尋, 牧廣利, 畠義郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 視神経損傷による機能低下に対する経角膜電気刺激の保護効果 (2007)
  • Author(s): 畠義郎
  • Organizer: シンポジウム「視覚機能の回復と代行」第84回日本生理学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-20
• [Presentation] 遺伝か環境か?-視覚経験に依存した脳発達- (2006)
  • Author(s): 畠義郎
  • Organizer: 第51回日本人類遺伝学会教育講演
  • Place of Presentation: 米子
  • Year and Date: 2006-10-18
• [Presentation] 薬理学的に抑制された発達視覚野における逆向きの眼優位可塑性の初期変化 (2006)
  • Author(s): 森島佑, 阪本広志, 赤崎孝文, 畠義郎
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 2006-07-19
• [Presentation] Experience-dependent regulation of extracellular signal-regulated kinase 1/2 activity and subcellular localization in rat visual cortex. (2005)
  • Author(s): Takamura, H., Ichisaka, S., Hayashi, C., Maki, H., Hata, Y.
  • Organizer: 35th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC.
  • Year and Date: 2005-11-12
• [Presentation] Experience-dependent retraction of geniculocortical arbors in the pharmachologically inhibited visual cortex. (2005)
  • Author(s): Hata, Y., Haruta, M.
  • Organizer: 35th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC.
  • Year and Date: 2005-11-12
• [Book] Synaptic elimination" in Encyclopedic Reference of Neuroscience (2009)
  • Author(s): Hata Y
  • Publisher: Springer-Verlag
• [Book] 視覚系の可塑性とその利用には何があるか?", 神経眼科をやさしく理解するための視覚と眼球運動のすべて (2007)
  • Author(s): 三宅賢一郎, 畠義郎
  • Publisher: メジカルビュー社