2009 Fiscal Year Final Research Report
Elucidating the role of extracellular matrix remodeling on the fate and behavior of neuron
| Project/Area Number |
17024026
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
NODA Makoto Kyoto University, 医学研究科, 教授 (30146708)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Tomoko 京都大学, 医学研究科, 助教 (50402855)
YOSHIDA Yoko 京都大学, 医学研究科, 助教 (60130324)
IMAMURA Yukio 京都大学, 医学研究科, 助教 (90447954)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAKI Tomoko 京都大学, 医学研究科, 助教 (50402855)
YOSHIDA Yoko 京都大学, 医学研究科, 助教 (60130324)
IMAMURA Yukio 京都大学, 医学研究科, 助教 (90447954)
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| Project Period (FY) |
2005 – 2009
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| Keywords | がん / 発生 / マウス遺伝学 / MMP / ADAM / Notch / シグナル伝達 |
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| Research Abstract |
RECK, first identified as a transformation suppressor gene, is expressed at relatively high levels in neural precursor cells (NPCs) in mouse embryos; in Reck-deficient mice, NPCs show reduced proliferation and precocious differentiation. Our study to understand the mechanism of this phenomenon revealed that Reck inhibits ADAM10- mediated Notch-ligand shedding. We also found that in the diaphragm of late-stage embryos, Reck rapidly accumulates in the neuromuscular junctions, mainly in the secondary folds of the post-synaptic muscle membrane.
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[Journal Article] RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin.2009
Author(s)
Omura A, Matsuzaki T, Mio K, Ogura T, Yamamoto M, Fujita A, Okawa K, Kitayama H,, Takahashi C, Sato C, Noda M..
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Journal Title
J Biol Chem 284
Pages: 3461-3469
Peer Reviewed
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[Journal Article] RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.2007
Author(s)
Muraguchi T, Takegami Y, Ohtsuka T, Kitajima S, Chandana EP, Omura A, Miki T, Takahashi R, Matsumoto N, Ludwig A, Noda M., Takahashi C.
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Journal Title
Nat Neurosci 10
Pages: 838-845
Peer Reviewed
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[Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.2007
Author(s)
Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H,, Hiraki Y, Noda M..
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Journal Title
J Cell Sci 120
Pages: 849-857
Peer Reviewed
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[Journal Article] Sept4, a Component of Presynaptic Scaffold and Lewy Bodies, Is Required for the Suppression of alpha-Synuclein Neurotoxicity.2007
Author(s)
Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M., Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M.
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Journal Title
Peer Reviewed
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[Journal Article] Prognostic significance of reversion-inducing cysteine-rich protein with Kazal motifs expression in resected pathologic stage IIIA N2 non-small-cell lung cancer.2005
Author(s)
Takenaka K, Ishikawa S, Yanagihara K, Miyahara R, Hasegawa S, Otake Y, Morioka Y, Takahashi C, Noda M., Ito H, Wada H, Tanaka F.
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Journal Title
Ann Surg Oncol 12
Pages: 817-824
Peer Reviewed
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[Journal Article] Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa.2005
Author(s)
Ihara M, Kinoshita A, Yamada S, Tanaka H, Tanigaki A, Kitano A, Goto M, Okubo K, Nishiyama H, Ogawa O, Takahashi C, Itohara S, Nishimune Y, Noda M., Kinoshita M.
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Journal Title
Dev Cell 8
Pages: 343-352
Peer Reviewed
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