2009 Fiscal Year Final Research Report
Analyses for regulation of brain system by using CNR/protocadherin molecules
| Project/Area Number |
17024034
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
YAGI Takeshi Osaka University, 大学院・生命機能研究科, 教授 (10241241)
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| Co-Investigator(Kenkyū-buntansha) |
HIRABAYASHI Takahiro 大阪大学, 大学院・生命機能研究科, 助教 (40297015)
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| Project Period (FY) |
2005 – 2009
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| Keywords | カドヘリン / 遺伝子クラスター / 神経細胞 / 神経回路 / 多様性 |
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| Research Abstract |
The brain is a complex system, and is composed of enormous number of neurons, which have individual activity. To understand mechanism of generation and regulation of the complex brain system, we try to examine molecular mechanisms for acquiring neuronal individuality and for generating neural networks in the brain. Here we revealed that about 50 members of CNR/protocadherin genes are differentially expressed in individual neurons, and their expressions are random and combinatorial in each neuron. Also molecules of CNR/protocadherin have significant function for generating correct neural networks during brain development.
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[Journal Article] Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha cluster.2009
Author(s)
Noguchi,Y., Hirabayashi,T., Katori,S., Kawamura,Y., Sanbo,M., Hirabayashi,M., Kiyonari,H., Nakao,K., Uchimura,A. Yagi,T
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Journal Title
J.Biol.Chem. 284
Pages: 32002-320014
Peer Reviewed
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[Journal Article] Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas.2009
Author(s)
Katori,S., Hamada,S., Noguchi,Y., Fukuda,E., Yamamoto,T., Yamamoto,H., Hasegawa,S. Yagi,T
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Journal Title
J.Neurosci. 29
Pages: 9137-9147 (2009)
Peer Reviewed
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[Journal Article] Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory.2008
Author(s)
Fukuda,E., Hamada,S., Hasegawa,S., Katori,S., Sanbo,M., Miyakawa,T., Yamamoto,T., Yamamoto,H., Hirabayashi,T. Yagi,T
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Journal Title
Eur.J.Neurosci. 28
Pages: 1362-1376
Peer Reviewed
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[Journal Article] The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse.2008
Author(s)
Hasegawa,S., Hamada,S., Kumode,Y., Esumi,S., Katori,S., Fukuda,E., Uchiyama,Y., Hirabayashi,T., Mombaerts,P. Yagi,T
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Journal Title
Mol.Cell.Neurosci. 38
Pages: 66-79
Peer Reviewed
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[Journal Article] Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells.2006
Author(s)
Kaneko,R., Kato,H., Kawamura,Y., Esumi,S., Hirayama,T., Hirabayashi,T. Yagi,T
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Journal Title
J.Biol.Chem. 281
Pages: 30551-30560
Peer Reviewed
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[Journal Article] Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice.2005
Author(s)
Osada,T., Tamamaki,N., Song,S.Y., Kakazu,N., Yamazaki,Y., Makino,H., Sasaki,A., Hirayama,T., Hamada,S., Nave,K.A,, Yanagimachi,R., Yagi,T
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Journal Title
J.Neurosci. 25
Pages: 8368-8374
Peer Reviewed
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[Journal Article] Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.2005
Author(s)
Esumi,S., Kakazu,N., Taguchi,Y., Hirayama,T., Sasaki,A., Hirabayashi,T., Koide,T., Kitsukawa,T., Hamada,S. Yagi,T
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Journal Title
Nat.Genet. 37
Pages: 171-176
Peer Reviewed
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