2009 Fiscal Year Final Research Report
Elucidation of molecular pathomechanisms of schizophrenia
| Project/Area Number |
17025016
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NISHIKAWA Toru Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (00198441)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Naoki 東京医科歯科大学, 医学部附属病院, 講師 (70312296)
KURUMAJI Akeo 東京医科歯科大学, 医学部附属病院, 准教授 (00251504)
TAKAO Keizo 京都大学, 医学系研究科, 講師 (80420397)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 統合失調症 / ドーパミン神経伝達 / グルタミン酸神経伝達 / NMDA型グルタミン酸受容体 / 内在性D-セリン / methamphetamine / phencyclidine / 脳部位 |
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| Research Abstract |
To clarify the molecular basis of schizophrenia, we have explored and detected the developmentally regulated schizophrenomimetic-inducible genes from the rat brain regions as thenovel candidates for schizophrenia-associated molecules in terms of the phenomena that schizophrenia and its pharmacological models usually occur after the specific postnatal period.Moreover, we have newly cloned and clarified the two genes and the glial regulation, respectively,which are closely related to the endogenous D-serine signal controls to get further cues for theinvestigation on the possible dysfunction of the NMDA type glutamate receptor and its co-agonistD-serine in the schizophrenia brains.
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