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2009 Fiscal Year Final Research Report

Elucidation of molecular pathomechanisms of schizophrenia

Research Project

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Project/Area Number 17025016
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NISHIKAWA Toru  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (00198441)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Naoki  東京医科歯科大学, 医学部附属病院, 講師 (70312296)
KURUMAJI Akeo  東京医科歯科大学, 医学部附属病院, 准教授 (00251504)
TAKAO Keizo  京都大学, 医学系研究科, 講師 (80420397)
Project Period (FY) 2005 – 2009
Keywords統合失調症 / ドーパミン神経伝達 / グルタミン酸神経伝達 / NMDA型グルタミン酸受容体 / 内在性D-セリン / methamphetamine / phencyclidine / 脳部位
Research Abstract

To clarify the molecular basis of schizophrenia, we have explored and detected the developmentally regulated schizophrenomimetic-inducible genes from the rat brain regions as thenovel candidates for schizophrenia-associated molecules in terms of the phenomena that schizophrenia and its pharmacological models usually occur after the specific postnatal period.Moreover, we have newly cloned and clarified the two genes and the glial regulation, respectively,which are closely related to the endogenous D-serine signal controls to get further cues for theinvestigation on the possible dysfunction of the NMDA type glutamate receptor and its co-agonistD-serine in the schizophrenia brains.

  • Research Products

    (24 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (3 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The development- and phencyclidine-regulated induction of synapse-associated protein-97 gene in the rat neocortex.2010

    • Author(s)
      Hiraoka, S., Kajii, Y., Kuroda, Y., Umino, A., Nishikawa, T.
    • Journal Title

      European Neuropsychopharmacol. 20

      Pages: 176-186

    • Peer Reviewed
  • [Journal Article] Developmentally regulated and thalamus-selective induction of leiomodin2 gene by a schizophrenomimetic, phencyclidine2009

    • Author(s)
      Takebayashi, H., Yamamoto, N., Umino, A., Nishikawa, T.
    • Journal Title

      rat. Int. J. Neuropsychopharmacol. 12

      Pages: 1111-1126

    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population. American journal of medical genetics.2009

    • Author(s)
      Hattori E, Nishikawa T (44名中19番目), Yoshikawa T, et al.
    • Journal Title

      Part B, Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics 150

      Pages: 1110-7

    • Peer Reviewed
  • [Journal Article] An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia.2008

    • Author(s)
      Sato, J., Shimazu, D., Yamamoto, N., Nishikawa, T.
    • Journal Title

      J. Neural Transm. 115

      Pages: 1355-1365

    • Peer Reviewed
  • [Journal Article] Effects of FG7142 and immobilization stress on the gene expression in the neocortex of mice.2008

    • Author(s)
      Kurumaji A, Ito T, Ishii S, Nishikawa T
    • Journal Title

      Neuroscience research 62

      Pages: 155-9

    • Peer Reviewed
  • [Journal Article] Sliding doors (but not with beans or tofu)2008

    • Author(s)
      Yamamoto N, Tsutsui K, Yamamoto M, Arakaki H, Kurumaji A, Nishikawa T
    • Journal Title

      Lancet 372

      Pages: 1782

    • Peer Reviewed
  • [Journal Article] Selective increase in the extracellular D-serine contents by D-cycloserine in the rat medial frontal cortex.2007

    • Author(s)
      Fujihira, T., Kanematsu, S., Umino, A., Yamamoto, N., Nishikawa, T.
    • Journal Title

      Neurochem. Int. 51

      Pages: 233-236

    • Peer Reviewed
  • [Journal Article] Effects of schizophrenomimetics on the expression of the CCN1 (CYR 61) gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat.2007

    • Author(s)
      Ito, T., Hiraoka, S., Kuroda, Y., Ishii, S., Umino, A., Kashiwa, A., Yamamoto, N., Kurumaji, A., Nishikawa, T.
    • Journal Title

      Int. J. Neuropsychopharmacol. 10

      Pages: 717-725

    • Peer Reviewed
  • [Journal Article] Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine.2007

    • Author(s)
      Kaneko, Y., Kashiwa, A., Ito, T., Ishii, S., Umino, A., Nishikawa, T.
    • Journal Title

      Neuropsychopharmacol. 32

      Pages: 658-664

    • Peer Reviewed
  • [Journal Article] Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain.2006

    • Author(s)
      Kanematsu, S., Ishii, S., Umino, A., Fujihira, T., Kashiwa, A., Yamamoto, N., Kurumaji, A., Nishikawa T
    • Journal Title

      J. Neural Transm. 113

      Pages: 1717-1721

    • Peer Reviewed
  • [Journal Article] Inhibition of D-serine accumulation in the Xenopus oocyte by expression of the rat ortholog of human 3'-phosphoadenosine 5'-phosphosulfate transporter gene isolated from the neocortex as D-serine modulator-1.2006

    • Author(s)
      Shimazu, D., Yamamoto, N., Umino, A., Ishii, S., Sakurai, S., Nishikawa, T.
    • Journal Title

      J. Neurochem. 96

      Pages: 30-42

    • Peer Reviewed
  • [Journal Article] The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.2005

    • Author(s)
      Fujii R, Okabe S, Urushido T, Inoue K, Yoshimura A, Tachibana T, Nishikawa T, Hicks GG, Takumi T
    • Journal Title

      Current Biology 15

      Pages: 587-593

    • Peer Reviewed
  • [Journal Article] Cloning of a D-serine-regulated transcript dsr-2 from rat cerebral neocortex.2005

    • Author(s)
      Taniguchi, G., Yamamoto, N., Tsuchida, H., Umino, A., Shimazu, D., Sakurai, S., Takebayashi, H., Nishikawa, T.
    • Journal Title

      J. Neurochem. 95

      Pages: 1541-1549

    • Peer Reviewed
  • [Journal Article] Metabolism and functional roles of endogenous D-serine in mammalian brains.2005

    • Author(s)
      Nishikawa T
    • Journal Title

      Biological & pharmaceutical bulletin 28

      Pages: 1561-1565

    • Peer Reviewed
  • [Journal Article] White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging.

    • Author(s)
      Shioiri A, Kurumaji A, Takeuchi T, Matsuda H, Arai H, Nishikawa T
    • Journal Title

      American journal of geriatric psychiatry (in press)

  • [Presentation] Dysfunction of NMDA receptor- D-serine system and schizophrenia, Symposium "Disturbed glutamate neurotransmission in schizophrenia as a target for development of novel antipsychotics"2008

    • Author(s)
      Nishikawa T.
    • Organizer
      13th Pacific Rim College of Psychiatrists Scientific Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-11-01
  • [Presentation] NMDA receptor, D-serine and Schizophrenia.2005

    • Author(s)
      Nishikawa, T.
    • Organizer
      8th World Congress of Biological Psychiatry
    • Place of Presentation
      Vienna
    • Year and Date
      2005-07-01
  • [Presentation] A molecular pharmacological approach to the vulnerability to schizophrenia.2005

    • Author(s)
      Nishikawa, T.
    • Organizer
      Society of Biological Psychiatry 60th Annual Scientific Convention
    • Place of Presentation
      Atlanta
    • Year and Date
      2005-05-26
  • [Book] 分子神経科学の視点から. 統合失調症生物学的背景(松下正明, 加藤敏, 神庭重信 編集, 精神医学対話)2008

    • Author(s)
      西川徹
    • Total Pages
      412-435
    • Publisher
      弘文堂
  • [Book] A systematic approach to the brain d-serine system.(Fujii N, Homma H, Bruecker H, Fisher GH, Konno R (eds. ), A New Frontier in Amino Acid and Protein Research.)2007

    • Author(s)
      Nishikawa T.
    • Total Pages
      151-167
    • Publisher
      Nova Science Publishers
  • [Book] Neuroanatomical and Molecular Changes in Stress Responses During Early Life: Implications for Stress Disorders,(Kato N, Kawata M Pitman RK (Eds. ), PTSD: Brain Mechanisms and Clinical Implications)2006

    • Author(s)
      Nishikawa T, Kurumaji A, Ito T, Umino A, Ishii S
    • Total Pages
      3-11
    • Publisher
      Springer-Verlag
  • [Remarks] 受賞日本油化学会第6回オレオサイエンス賞受賞受賞者西川徹 平成19年9月

  • [Remarks] プレス発表 読売新聞平成20年12月7日版 『Dアミノ酸ー陰の存在実は「主役」?ー』 西川 徹

  • [Patent(Industrial Property Rights)] 高速液体クロマトグラフィーによるアミノ酸の分析方法2008

    • Inventor(s)
      酒井芳博・太田鈴枝・西川徹 権利者:東京医科歯科大学
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      特許第4129511号
    • Filing Date
      2008-05-30
    • Acquisition Date
      2008-05-30

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Published: 2011-06-18   Modified: 2016-04-21  

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