Analysis of immune mechanisms of Alzheimer's disease and development of a novel treatment

2009 Fiscal Year Final Research Report

• Project/Area Number: 17025056
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Juntendo University (2008-2009); National Institute for Longevity Sciences,NCGG (2005-2007)
• Principal Investigator: TABIRA Takeshi Juntendo University, 大学院・医学研究科, 教授 (80112332)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Keikichi 国立長寿医療センター研究所, 血管性認知症研究部, 部長 (40117148) ; HARA Hideo 国立長寿医療センター研究所, 血管性認知症研究部, 室長 (00260381) ; SEKIYAMA Atsuo 国立長寿医療センター研究所, 血管性認知症研究部, 室長 (30403702) ; MATSUMOTO Shinei 順天堂大学, 大学院・医学研究科, 助教 (40432950)
• Project Period (FY): 2005 – 2009
• Keywords: アルツハイマー病 / アミロイド / ワクチン / 漢方薬 / ミクログリア / モノクローナル抗体

Research Abstract

An herbal medicine Juzentaihoto activated bone marrow-derived macrophage/microglia and enhanced clearance of senile plaque amyloid. We established a new monoclonal antibody 3.4A10, which recognized a conformational structure of Aβ42, reduced senile plaque amyloid as well as Aβ oligomers, and improved cognitive functions without enhancing cerebral micro-hemorrhages. This is expected to be used as a disease modifying antibody.

Research Products

• [Journal Article] Immunization therapy for Alzheimer disease: A comprehensive review of active immunization strategies (2010)
  • Author(s): Tabira T.
  • Journal Title: Tohoku J Exp 220 Pages: 95-106
• [Journal Article] The therapeutic effects of herbal medicine, Juzen-taiho-to on the reduction of A・burden in a mouse model of Alzheimer's disease (2010)
  • Author(s): Hara H, Kataoka S, Anan M, Ueda A, Mutoh T, Tabira T.
  • Journal Title: J Alzheim (in press)
• [Journal Article] Decorated plaques in Alzheimer's disease (2009)
  • Author(s): Tabira T.
  • Journal Title: Ann Neurology 65(1) Pages: 4-6
• [Journal Article] Developmentand characterization of a TAPIR-like mouse monoclonal antibody to Aβ (2008)
  • Author(s): Wang, J., Hara, H., Makifuchi, T., TabiT.
  • Journal Title: J Alzheim Dis 14 Pages: 161-73
• [Journal Article] Oral vaccination with a recombinant adeno-associated viral vector attenuates age-related Abeta accumulation and memory deficits without lymphocytic infiltration in Tg2576 mice (2007)
  • Author(s): Mouri, A., Noda, Y., Hara, H., Mizoguchi, H., Tabira, T., Nabeshima, T.
  • Journal Title: FASEB J. 21 Pages: 2135-48
• [Presentation] Alzheimer's disease vaccine (2009)
  • Author(s): Tabira T
  • Organizer: 2ND German-Japanese Neuroimmunology Symposium
  • Place of Presentation: Eibsee, Gremany
  • Year and Date: 2009-07-11
• [Book] アルツハイマー病に克つ (2009)
  • Author(s): 田平武
  • Total Pages: 255
  • Publisher: 朝日新書
• [Patent(Industrial Property Rights)] アルツハイマー病治療の為のタピール様抗体 (2008)
  • Inventor(s): 田平武、王軍
  • Industrial Property Rights Holder: 田平武、王軍
  • Industrial Property Number: 特願PCT/JP2009/53029
  • Filing Date: 2008-02-22