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2009 Fiscal Year Final Research Report

Establishment of Bio-nanotool for Local-environmental Measurement and Control by Nano-assembly System

Research Project

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Project/Area Number 17076004
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionNagoya University

Principal Investigator

FUKUDA Toshio  Nagoya University, 工学研究科, 教授 (70156785)

Co-Investigator(Kenkyū-buntansha) SAITO Yahachi  名古屋大学, 大学院・工学研究科, 教授 (90144203)
NAKAJIMA Masahiro  名古屋大学, 大学院・工学研究科, 助教 (80377837)
IMAIZUMI Yoshiaki  名古屋大学, 大学院・工学研究科, 研究員 (00377813)
Project Period (FY) 2005 – 2009
Keywordsナノアセンブリ / 局所環境計測・制御 / バイオナノツール
Research Abstract

Recently, analysis and control of biological system, especially for biological cell which is one of the primitive units of biological system, have been widely investigated. The important technique is to control and observe their local environment dynamically. However, the high precision measurement of electrochemical gradient, ionic concentration, and so on, is basically difficult in nano-scale until now. And, low/noninvasive measurement techniques for their physical/chemical properties are also needed.
In this research, we established bio-nanotools to measure and control the local environment of biological cells based on nanomanipulation technique by integrating material science, measurement/control/fabrication technologies. We proposed novel local environmental measurement and control technique by applying nano-meter scale bio-nanotools to micro-meter scale biological cell.

  • Research Products

    (16 results)

All 2010 2009 2008 Other

All Journal Article (8 results) Presentation (5 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Micro- and Nanomechatronics2010

    • Author(s)
      T.Fukuda, M.Nakajima, M.R.Ahmad, Y.Shen, M.Kojima
    • Journal Title

      IEEE Industrial Electronics Magazine, refereed Vol.4

      Pages: 13-22

  • [Journal Article] Nanoliters Discharge/ Suction by Thermoresponsive Polymer Actuated Probe and Applied for Single Cell Manipulation2010

    • Author(s)
      M.Takeuchi, M.Nakajima, M.Kojima, T.Fukuda
    • Journal Title

      refereed, J.of Robotics and Mechatronics Vol.22, No.5

      Pages: 644-650

  • [Journal Article] Quantitative Evaluation of Injected Molecules into Phospholipid-Coated Microdroplets for In-Situ Biological Reactions2010

    • Author(s)
      M.Nakajima, Y.Matsuno, M.Kojima, Y.Takiguchi, K.Takiguchi, K.Nogawa, M.Homma, T.Fukuda
    • Journal Title

      refereed, J.of Robotics and Mechatronics Vol.22, No.5

      Pages: 651-658

  • [Journal Article] Nanoindentation Methods to MeasureViscoelastic Properties of SingleCells Using Sharp, Flat, and BucklingTips Inside ESEM, refereed2010

    • Author(s)
      M.Ridzuan Ahmad, M.Nakajima, S.Kojima, M.Homma, T.Fukuda
    • Journal Title

      IEEE Transactions on Nanobioscience Vol.9, No.1

      Pages: 12-23

  • [Journal Article] Nanofabrication, Nanoinstrumentaion and Nanoassembly by Nanorobotic Manipulation2009

    • Author(s)
      T.Fukuda, M.Nakajima, P.Liu, El-Shimy Magdy
    • Journal Title

      The International Journal of Robotics Research, refereed Vol.28, No.4

      Pages: 537-547

  • [Journal Article] Rotational Speed Control ofNa+-driven Flagellar Motor by DualPipettes2009

    • Author(s)
      K.Nogawa, M.Kojima, M.Nakajima, S.Kojima, M.Homma, T.Fukuda
    • Journal Title

      IEEE Transactions on Nanobioscience, refereed Vol.8, No.4

      Pages: 341-348

  • [Journal Article] Nano Robotic Manipulation insideElectron Microscopes2008

    • Author(s)
      T.Fukuda, M.Nakajima, P.Liu
    • Journal Title

      SICE J.of Control, Measurement, and System Integration, refereed Vol.1, No.1

      Pages: 40-50

  • [Journal Article] The Effects of Cell Sizes, Environmental Conditions and Growth Phases on the Strength of Individual W303 Yeast Cells using ESEM-Nanomanipulator2008

    • Author(s)
      M.R.Ahmad, M.Nakajima, S.Kojima, M.Homma, T.Fukuda
    • Journal Title

      IEEE Transactions on Nanobioscience, refereed Vol.7, Issue3

      Pages: 185-193

  • [Presentation] Micro-Nano Robotics and Automation System2010

    • Author(s)
      T.Fukuda, M.Nakajima, M.Kojima
    • Organizer
      Large Scale Systems : Theory and Applications (12th LSS Symposium)
    • Place of Presentation
      Villeneuve d'Ascq, France
    • Year and Date
      20100700
  • [Presentation] Mechatronics-Past, Present and Future-2010

    • Author(s)
      T.Fukuda, M.Nakajima
    • Organizer
      Mechatronics 2010
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      20100600
  • [Presentation] Manipulation of Flagellar Driving Force by Local Environmental Control System with Multiple Nanoprobes2010

    • Author(s)
      K.Nogawa, M.Kojima, M.Nakajima, Michio Homma, Toshio Fukuda
    • Organizer
      2011 IEEE International Conference on Robotics and Automation (ICRA2010)
    • Place of Presentation
      Anchorage, USA
    • Year and Date
      20100500
  • [Presentation] Micro - Nano Robotic Manipulation System2009

    • Author(s)
      T.Fukuda
    • Organizer
      Workshop on Intelligent Systems
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      20090800
  • [Presentation] Semi-Closed Microchip for Probe Manipulation and the Target Cell Harvesting (I)2009

    • Author(s)
      M.Takeuch, M.Nakajima, T.Fukuda
    • Organizer
      The 2009 IEEE International Conference on Robotics and Automation (ICRA2009)
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20090500
  • [Book] 細胞分離・操作技術の最前線

    • Author(s)
      監修福田敏男, 新井史人
    • Total Pages
      387
    • Publisher
      シーエムシー出版刊
  • [Remarks] ホームページ等

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/Bio-manipulation/index-j.html

  • [Patent(Industrial Property Rights)] 感熱応答性ポリマーを用いた微小物操作のためのプローブ型装置2010

    • Inventor(s)
      福田敏男, 中島正博, 小嶋勝, 竹内大
    • Industrial Property Rights Holder
      福田敏男, 中島正博, 小嶋勝, 竹内大
    • Industrial Property Number
      特願,2010-261750
    • Filing Date
      2010-11-05

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Published: 2012-02-13   Modified: 2016-04-21  

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