2009 Fiscal Year Final Research Report
New research initiatives in the study of G-protein signaling systems integrating cell communication network
| Project/Area Number |
17079001
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATADA Toshiaki The University of Tokyo, 大学院・薬学系研究科, 教授 (10088859)
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| Co-Investigator(Kenkyū-buntansha) |
KANAHO Yasunori 筑波大学, 大学院・人間総合科学研究科, 教授 (00214437)
NEGISHI Manabu 京都大学, 生命科学研究科, 教授 (60201696)
ITOH Hiroshi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (10183005)
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| Project Period (FY) |
2005 – 2010
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| Keywords | タンパク質 / 遺伝子 / シグナル伝達 / G蛋白質 |
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| Research Abstract |
G proteins cycle between the two different GTP- and GDP-bound conformations (G cycles), and play important roles as a "molecular switch" in many intracellular signaling pathways. Although G proteins have been classified into three major families such as the translation factors, the trimeric G proteins, and the small GTPases, recent findings indicate that there are still many other members in the families and their regulatory factors, whose functions and molecular mechanisms are unknown. In the Scientific Research on Priority Areas "G-protein signal", we investigated the common and/or different molecular mechanisms among the regulation of various G cycles to introduce a novel concept in the G protein signaling. Our findings would facilitate the understanding of the specificity and diversity induced by G cycle-dependent cell functions.
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[Journal Article] Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.2010
Author(s)
Nishida M, Suda R.Nagamatsu Y, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Shibata T, Uchida K., Sumimoto H, Sato Y, Kurose H.
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Journal Title
J.Biol.Chem. 285
Pages: 15268-15277
Peer Reviewed
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[Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010
Author(s)
Kimura T, Tomura T, Sato K, Ito M, Matsuoka I, Im D, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
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Journal Title
J.Biol.Chem. 285
Pages: 4387-4397
Peer Reviewed
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[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.2009
Author(s)
Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
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Journal Title
Science 324
Pages: 384-387
Peer Reviewed
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[Journal Article] Loss of PIP5KIb demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.2008
Author(s)
Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS.
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Journal Title
Proc.Natl.Acad.Sci.USA. 105
Pages: 14064-16069
Peer Reviewed
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[Journal Article] Control of cell polarity and motility by the PtdIns(3,4,5)P(3) phosphatase SHIP1.2007
Author(s)
Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, Balla T, Yamazaki M, Watanabe H, Itoh R, Kuroda S, Horie Y, Forster I, Mak TS, Yonekawa H, Penninger JM, Kanaho Y, Suzuki A, Sasaki T.
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Journal Title
Nat.Cell Biol. 9
Pages: 36-44
Peer Reviewed
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[Journal Article] Rac-GAP a-chimerin regulates motor-curcuit formation as a key mediator of Ephrin B3/EphA4 forward signaling.2007
Author(s)
Iwasato T, Katoh H, Nishimaru H, Ishikawa Y, Inoue H, Saito Y, Ando R, Iwama M, Takahashi R, Negishi M, Itohara S.
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Journal Title
Peer Reviewed
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[Journal Article] Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.2006
Author(s)
Suzuki T, Kanai Y, Hara T, Sasaki J, Sasaki T, Kohara M, Maehama T, Taya C, Shitara H, Yonekawa H, Frohaman MA, Yokozeki T, Kanaho Y.
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Journal Title
Mol.Cell.Biol. 26
Pages: 6149-6156
Peer Reviewed
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