2009 Fiscal Year Final Research Report
Functional analysis of atypical G proteins involved in cell signaling network
| Project/Area Number |
17079002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATADA Toshiaki The University of Tokyo, 大学院・薬学系研究科, 教授 (10088859)
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| Co-Investigator(Kenkyū-buntansha) |
KONTANI Kenji 東京大学, 大学院・薬学系研究科, 准教授 (30302615)
KAJIHO Hiroaki 東京大学, 大学院・薬学系研究科, 助教 (70401221)
FUKUYAMA Masamitsu 東京大学, 大学院・薬学系研究科, 助教 (20422389)
KOBAYASHI Tetsuo 東京大学, 大学院・薬学系研究科, 助教 (80433994)
SAITO Kota 東京大学, 大学院・薬学系研究科, 助教 (60549632)
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| Project Period (FY) |
2005 – 2009
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| Keywords | タンパク質 / 遺伝子 / シグナル伝達 / G蛋白質 / 小胞輸送 / リソソーム |
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| Research Abstract |
G proteins, which cycle between the two different GTP- and GDP-bound conformations, play important roles as a "molecular switch" in many intracellular signaling pathways. The G protein families include the translation factors, the trimeric G proteins, and the small GTPases. Although the small GTPases are involved in the regulation of cell growth/differentiation, vesicle trafficking, and cell shape/adhesion, there are still many other GTPases, of which functions are unknown. In the Scientific Research on Priority Areas "G-protein signal", we investigated novel GTPases exhibiting unique biochemical and/or structural properties different from typical small GTPases and found that the atypical G proteins play important roles in lysosome biogenesis, cilia formation, and recycling-endosome dynamics. Thus, our findings contributed much toward an understanding of the novel functions of G proteins.
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[Journal Article] Filamin associates with stress signaling kinases MKK7 and MKK4 and regulates JNK activation.2010
Author(s)
Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H.
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Journal Title
Biochem J. 427(2)
Pages: 237-245
Peer Reviewed
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[Presentation] The Arf-like GTPase ARL-8 is required for lysosome biogenesis in C. elegans2009
Author(s)
Nakae I, Fujino T, Kobayashi T, Kikko Y, Harada S, Fukuyama M, Gengyo-, o K, Mitani S, Kontani K, Katada T
Organizer
17th International C. elegans Meeting
Place of Presentation
Los Angeles, CA, USA
Year and Date
2009-06-27
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[Presentation] Nakagawa S, Kontani K, Katada T.: Tyrphosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.2008
Author(s)
Kajiho H, Yoshikawa M, Sakurai K, Minoda T, Nakagawa S, Kontani K, Katada T.
Organizer
48th ASCB Annual Meeting
Place of Presentation
米国、サンフランシスコ
Year and Date
20081200
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