2009 Fiscal Year Final Research Report
Physiological regulation of G protein signaling by RGS proteins
| Project/Area Number |
17079005
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
KURACHI Yoshihisa Osaka University, 医学系研究科, 教授 (30142011)
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| Co-Investigator(Kenkyū-buntansha) |
INANOBE Atsushi 大阪大学, 医学系研究科, 准教授 (00270851)
MURAKAMI Shingo 大阪大学, 医学系研究科, 助教 (40437314)
FURUTANI Kazuharu 大阪大学, 医学系研究科, 助教 (40452437)
ISHII Masaru 大阪南医療センター(臨床研究部), 免疫異常疾患研究所, 研究員 (10324758)
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| Project Period (FY) |
2005 – 2009
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| Keywords | G蛋白質 / RGS蛋白質 / 細胞内シグナル / カルシウムシグナル / カリウムチャネル / 数理モデル |
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| Research Abstract |
Trimeric G proteins transmit extracellular signals to regulate the intracellular effectors. The spatiotemporal regulation of this signal closely links to the cellular responses. In this study, we addressed the regulation of G protein signaling by RGS proteins, the mathematical models of G protein signaling and the structure-function relationship of K^+ channel to analyze the physiological regulation of G protein signaling.
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