2009 Fiscal Year Final Research Report
Identification and analysis of new molecules that regulate G protein signaling
| Project/Area Number |
17079006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
ITOH Hiroshi Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (10183005)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Norikazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (90212232)
TAGO Kenji 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (20306111)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Keywords | G蛋白質 / シグナル伝達 / 創薬科学 |
|---|
| Research Abstract |
In this study, we found that orphan G protein-coupled receptor, GPR56, negatively regulates neural progenitor cell migration via G12/13 and Rho pathway, and the antibody which recognizes the orphan receptor is an useful tool for analyzing the function of the receptor. Moreover, structural basis for the specific inhibition of G proteins by YM-254890 has been revealed by biochemical and X-ray crystal structure analysis. Ubiquitination of the stimulatory G protein ・ subunit and its inhibition by Ric-8B was demonstrated. Crosstalk between G protein signaling and dioxin signaling was found by identifying AIP as a novel G protein interacting protein.
|
-
-
[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2010
Author(s)
Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H. Sutherl, LC, Brachmann RK.
-
Journal Title
Int J Cancer 126(in press)
Peer Reviewed
-
-
-
[Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells2010
Author(s)
Kimura T, Tomura T, Sato K, Ito M, Matsuoka I, Im D, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
-
Journal Title
J Biol Chem 285
Pages: 4387-4397
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc422006
Author(s)
Murata T, Ohnishi H, Okazawa H, Murata Y, Kusakari S, Hayashi Y, Miyashita M, Itoh H, Oldenborg P. A, Furuya N, Matozaki T.
-
Journal Title
J Neurosci 26
Pages: 12397-12407
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] A novel type of G protein inhibitor2007
Author(s)
Nishimura A, Sugawara Y, Takasaki J, Taniguchi M, Mizuno N, Itoh H.
Organizer
YM-254890, acts as a Gq- specific guanine nucleotide dissociation inhibitor via the switch 1 region of Galpha subunit, Experimental Biology Annual Meeting
Place of Presentation
Washington DC
Year and Date
2007-04-28
-
-
-
-
-
-
-
-
-
-
