2009 Fiscal Year Final Research Report
Molecular mechanism of the connection between chromosome networks and recombination
| Project/Area Number |
17080004
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
SHINOHARA Akira Osaka University, 蛋白質研究所, 教授 (00252578)
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| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA Miki 大阪大学, 蛋白質研究所, 准教授 (80335687)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 減数分裂 / 組換え / 染色体 |
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| Research Abstract |
Genetic change in meiosis is driven by homologous recombination. The recombination not only generates diversity in the genome, but also plays an essential role in chromosome segregation at meiosis I. Meiotic recombination is mechanistically different from that in mitosis with more complex regulation. From this study, we have identified several key proteins/genes in the recombination which tell us a new idea on the mechanisms of meiotic recombination. Particularly, we have identified an active role of chromosome dynamics and structure in the control of the recombination.
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[Journal Article] Telomeres drive rapid movements regulated by chromosome status in meiotic prophase.2008
Author(s)
Conrad, M.N., Lee, C. -Y., Chao, G., Shinohara, M., Kosaka, H., Shinohara, A., Conchello, J. -A., *M.E. Dresser.
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Journal Title
Cell. 133
Pages: 1175-1187
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