2009 Fiscal Year Final Research Report
Studies on assembly, maintenance, and reorganization of replication fork complexes
| Project/Area Number |
17080006
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
TSURIMOTO Toshiki Kyushu University, 理学研究院, 教授 (30163885)
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| Co-Investigator(Kenkyū-buntansha) |
ISHINO Yoshizumi 九州大学, 農学研究院, 教授 (30346837)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 複製フォーク / 複製装置 / DNA損傷 / 染色体 / クランプ / ATPase |
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| Research Abstract |
The core structure of chromosomes is organized during DNA replication. We have studied assembly and dynamics of the replication fork complex of human and archaeal cells. We identified novel proteins from human cells, interacting with replication clamp PCNA, loader complex RFC and their paralogs. These results will provide new insights on coupling between DNA replication and maintenance of genome integrity. We also studied structures and functions of archaeal replication proteins, and demonstrated molecular assemblies of the replication fork during progression and upon DNA damage response.
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Research Products
(71 results)
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[Journal Article] DNA damage induced ubiquitylation of RFC2 subunit of RFC complex2008
Author(s)
Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T.
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Journal Title
J Biol Chem. 283
Pages: 9071-9079
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[Journal Article] Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks2008
Author(s)
Tsuji Y, Watanabe K, Araki K, Shinohara M, Yamagata Y, Tsurimoto T, Hanaoka F, Yamamura K, Yamaizumi M, Tateishi, S.
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Journal Title
Genes Cells 13
Pages: 343-354
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[Journal Article] Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis2006
Author(s)
Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama K-I, Nakayama K, Fujita M, Lygerou Z, Nishimoto T.
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Journal Title
EMBO J. 25
Pages: 1126-1136
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