2009 Fiscal Year Final Research Report
Analysis of gene amplification that is promoted by DNA replication and homologous recombination
| Project/Area Number |
17080010
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute of Genetics (2006-2009)
National Institute for Basic Biology (2005) |
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Principal Investigator |
KOBAYASHI Takehiko National Institute of Genetics, 細胞遺伝研究系, 教授 (40270475)
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| Project Period (FY) |
2005 – 2009
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| Keywords | リボソームRNA遺伝子 / 遺伝子増幅 / ゲノムの安定性 / 非コード転写 / 細胞老化 |
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| Research Abstract |
The ribosomal RNA genes (rDNA) are one of the most fragile sites for deletional recombination. Even though the rDNA is susceptible to this kind of instability, each organism maintains a specific copy number of rDNA, thereby indicating presence of a mechanism for the maintenance of copy number. I revealed that there is a gene amplification system to maintain the copy number. Moreover, I found that rDNA instability was a cause of cellular senescence.
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