2009 Fiscal Year Final Research Report
Interplay among recombination, replication, segregation, and chromatin structure.
| Project/Area Number |
17080011
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo (2007-2009)
The Institute of Physical and Chemical Research (2005-2006) |
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Principal Investigator |
OHTA Kunihiro The University of Tokyo, 大学院・総合文化研究科, 教授 (90211789)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Kouji 独立行政法人理化学研究所, 基礎科学特別研究員 (00342840)
FUKUDA Tomoyuki 独立行政法人理化学研究所, 基礎科学特別研究員 (90415282)
BRANZEI Dana 独立行政法人理化学研究所, 基礎科学特別研究員 (20392102)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Takatomi 東京大学, 大学院・総合文化研究科, 助教 (30451850)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 組換え / 減数分裂 / 複製 / クロマチン |
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| Research Abstract |
Meiotic recombination plays crucial roles in establishment of genetic diversity and gametes formation. The regulation of meiotic recombination involves various DNA-related processes. This project uncovered that meiotic recombination initiator Spo11 is activated by phosphorylation of a Spo11-accesspry protein Mer2 by Cdc7-Dbf4 kinase, which is a master regulator of DNA replication cycle. We also discovered that Spo11 distribution is regulated by meiotic chromatid cohesion protein Rec8 and replication. In addition, we found several factors involved in chromatin modification required for the activation of meiotic recombination hotspots. Finally, we discovered a new class of long mRNA-type non-coding RNA involved in chromatin control for the stress-induced gene activation in fission yeast.
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Research Products
(90 results)
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[Journal Article] Actin-related protein Arp6 influences H2AZ-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores.2010
Author(s)
Yoshida T., Shimada K., Oma Y., Kalck V., Akimura K., Taddei A., Iwahashi H., Kugou K., Ohta K., Gasser S.M., Harata M.
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Journal Title
Peer Reviewed
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[Journal Article] Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes.2009
Author(s)
Kugou K., Yamada S., Itoh M., Fukuda T., Sasanuma H., Mori S., Katou Y., Itoh T., Matsumoto K., Shibata T., Shirahige K., Ohta K.
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Journal Title
Mol. Biol. Cell 20
Pages: 3064-3076
Peer Reviewed
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[Journal Article] Structural and functional analyses of the DMC1-M200V polymorphism found in the human population. Nucl.2008
Author(s)
Hikiba J., Hirota K., Kagawa W., Ikawa S., Kinebuchi T., Sakane I., Takizawa, Yokoyama S., Mandon-Pepin B., Nicolas A., Shibata S., Ohta K. Kurumizaka H.
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Journal Title
Acids Res. 36
Pages: 4181-4190
Peer Reviewed
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[Journal Article] Actin-related protein Arp4 functions in kinetochore assembly. Nucl.2007
Author(s)
Ogiwara H., Ui, A., Kawashima S., Kugou K., Onoda F., Iwahashi H., Harata M., Ohta K., Enomoto T., Seki M.
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Journal Title
Acids Res. 35
Pages: 3109-3117
Peer Reviewed
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[Journal Article] Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis.2005
Author(s)
Tokai T., Koshino, H., Kawasaki, T., Igawa, T., Suzuki, Y., Sato, M., Fujimura, M., Eizuka, T., Watanabe, H., Ohta, K., Shibata, T., Kudo, T., Inoue, H., Yamaguchi, I., Kimura, M.
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Journal Title
FEMS Microbiol. Lett. 251
Pages: 193-201
Peer Reviewed
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[Remarks] Genes & Genetic Systems Award 2008(日本遺伝学会論文賞)
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[Remarks] 平成19年(2007年)文部科学大臣表彰科学技術賞(研究部門)プレス発表
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[Remarks] 「ガラクタ」RNAの遺伝子活性化における新しい役割(2008/9/29)
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[Remarks] 生命多様化のエンジン:組み換え酵素Spo11活性化機構を解明(2008. 2. 1)
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[Remarks] ガン化と関連する異常なdna組換えを抑えるタンパク質のsumo化を発見(2006/11/3)
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