2009 Fiscal Year Final Research Report
Construction and analyses of interaction network for transportsomeusing structural information
| Project/Area Number |
17081003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KINOSHITA Kengo The University of Tokyo, 大学院・情報科学研究科, 教授 (60332293)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Haruki 大阪大学, 蛋白質研究所, 教授 (80134485)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 膜輸送複合体 / トランスポートソーム / DNAマイクロアレイ / 遺伝子共発現 / タンパク質立体構造 / タンパク質間相互作用 |
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| Research Abstract |
Construction of interaction network of protein is a first step toward the understanding of complex biological systems. Usually, the network is made from nodes and edges representing proteins and interactions, respectively. However, the abstract representation prevents us from analyzing the biological systems in molecular levels. Therefore, in this project, we have developed a method to construct the interaction networks based on gene coexpression, and also develop a method to predict the protein complex structures.
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[Journal Article] Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant2007
Author(s)
Y Hosaka, M Iwata, N Kamiya, M Yamada, K Kinoshita, Y Fukunishi, K Tsujimae, H Hibino, Y Aizawa, A Inanobe, H Nakamura, Y Kurachi
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Journal Title
Channels 1,1
Pages: 198-208
Peer Reviewed
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