2009 Fiscal Year Final Research Report
Analysis of the function and regulatory mechanism of drug transportsome
| Project/Area Number |
17081006
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUZUKI Hiroshi The University of Tokyo, 医学部附属病院, 教授 (80206523)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Yuichi 東京大学, 大学院・薬学系研究科, 教授 (80090471)
ITO Kousei 東京大学, 医学部附属病院, 准教授 (30323405)
SUGAWARA Yasuhiko 東京大学, 医学部附属病院, 准教授 (90313155)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 生理学 / 薬理学 / 薬剤反応性 |
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| Research Abstract |
We started a study for the purpose of clarifying a regulation mechanism of the biliary excretion transporters involved in homeostatic maintenance of the bile components. As a result, we identified molecules interacting with a series of transporters by yeast two-hybrid screening. These molecules selectively regulate the expression and localization of organic anion transporter and phospholipid transporter. Concerning to the cholesterol transporter, we have identified a molecule stimulating cholesterol efflux mediated by ABCG5/G8 from outside cells. Finally, we started research related to bone homeostasis especially focusing on RANKL which is a key regulator of bone resorption/bone formation. As a result, we succeeded in identifying a series of interacting molecules and signaling cascade regulating the biosynthesis and trafficking of RANKL in osteoblastic cells. Those are known to be involved in cellular signaling and vesicular trafficking in other cells. We proposed for the first time that these machinery play role in regulation of RANKL as well as phenotype of bone homeostasis.
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[Journal Article] Common Defects of ABCG2, a High-capacity Urate Exporter, Cause Gout : A Function-based Genetic Analysis in a Japanese Population.2009
Author(s)
Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Hamajima N, Shinomiya N.
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Journal Title
Science Translational Medicine 1(5ra11)
Pages: 41-48
Peer Reviewed
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[Journal Article] Posttranslational regulation of Abcc2 expression by SUMOylation system.2009
Author(s)
Minami S, Ito K, Honma M, Ikebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, Suzuki H.
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Journal Title
Am J Physiol Gastrointest Liver Physiol 296(2)
Pages: G406-G413
Peer Reviewed
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[Journal Article] Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.2007
Author(s)
Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H.
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Journal Title
Am J Physiol Gastrointest Liver Physiol 292(5)
Pages: G1450-G1463
Peer Reviewed
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[Presentation] 世界初の主要な痛風遺伝子の発見2009
Author(s)
松尾洋孝, 高田龍平, 市田公美, 鈴木洋史, 四ノ宮成祥
Organizer
Science Translational Medicine創刊記念講演会(依頼講演)
Place of Presentation
横浜
Year and Date
2009-11-10
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