2009 Fiscal Year Final Research Report
Analyses of functional the micro-platform mediating K^+ and water transport
| Project/Area Number |
17081012
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
HIBINO Hiroshi Osaka University, 医学系研究科, 准教授 (70314317)
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| Co-Investigator(Kenkyū-buntansha) |
KURACHI Yoshihisa 大阪大学, 医学系研究科, 教授 (30142011)
NOMURA Taishin 大阪大学, 基礎工学研究科, 教授 (50283734)
YAGI Tetsuya 大阪大学, 工学研究科, 教授 (50183976)
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| Project Period (FY) |
2005 – 2009
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| Keywords | アストロサイト / K^+チャネル・水チャネル / 輸送体 / 微小ドメイン |
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| Research Abstract |
Brain astroglial cells uptake excess extracellular K^+, which is induced by neural activity, and excrete it to blood vessels. This unidirectional K^+-transport is called "K^+-buffering" and accompanied with water movement. These two transports are respectively mediated by a K^+ channel, Kir4.1, and a water channel, AQP4, both of which occur together on the same membrane domain of the astroglial cells. In this study, we have found that Kir4.1 and AQP4 are expressed and functioned at the different micro-platforms containing distinct types of lipids. Furthermore, certain population of these two platforms is localized at the close vicinity, which would be involved in the coupling between K^+ and water transports across the astroglial cells.
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[Journal Article] Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4. 1 and Kir4. 2 results in inhibition of channel function.2007
Author(s)
Huang C, Sindic A, Hill CE, Hujer KM, Chan KW, Sassen M, Wu Z, Kurachi Y, Nielsen S, Romero MF, Miller RT.
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Journal Title
Am J Physiol Renal Physiol. 292
Pages: F1073-1081
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